Effectiveness of Educational Intervention on Influenza Vaccine Uptake: A Meta-Analysis of Randomized Controlled Trials

BACKGROUND: This study aimed to explore effective education method to improve influenza vaccine uptake rate. METHODS: Meta-analysis of Randomized Clinical Trials was conducted in this study including subgroup analysis and publication bias test. Electronic databases comprised PubMed, EBSCO, Elsevier, Springer, Wiley, and Cochrane were searched for studies published up to Oct 8, 2019. RESULTS: Influenza vaccination was significantly different in massages or letters intervention group (OR=1.30, 95%CI: 1.05–1.61). No heterogeneity and publication bias existed in this meta-analysis (I(2)=43.60%, P=0.131, P(begg) =0.754, P(egger)=0.051). CONCLUSION: Education by messages and letters was effective according to this study. Education messages could be more efficacy combined with easer vaccine access.