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Nutritional Support in Malnourished Children With Compromised Gastrointestinal Function: Utility of Peptide-Based Enteral Therapy

This review focuses on nutritional support in malnourished children with compromised gastrointestinal function addressing the interplay between malnutrition and gastrointestinal dysfunction, and the specific role of peptide-based enteral therapy in pediatric malnutrition. Malnutrition is associated...

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Autores principales: Selimoglu, Mukadder Ayse, Kansu, Aydan, Aydogdu, Sema, Sarioglu, Aysugul Alptekin, Erdogan, Simge, Dalgic, Buket, Yuce, Aysel, Cullu Cokugras, Fugen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8215107/
https://www.ncbi.nlm.nih.gov/pubmed/34164352
http://dx.doi.org/10.3389/fped.2021.610275
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author Selimoglu, Mukadder Ayse
Kansu, Aydan
Aydogdu, Sema
Sarioglu, Aysugul Alptekin
Erdogan, Simge
Dalgic, Buket
Yuce, Aysel
Cullu Cokugras, Fugen
author_facet Selimoglu, Mukadder Ayse
Kansu, Aydan
Aydogdu, Sema
Sarioglu, Aysugul Alptekin
Erdogan, Simge
Dalgic, Buket
Yuce, Aysel
Cullu Cokugras, Fugen
author_sort Selimoglu, Mukadder Ayse
collection PubMed
description This review focuses on nutritional support in malnourished children with compromised gastrointestinal function addressing the interplay between malnutrition and gastrointestinal dysfunction, and the specific role of peptide-based enteral therapy in pediatric malnutrition. Malnutrition is associated with impaired gut functions such as increased intestinal permeability, malabsorption, and diarrhea, while pre-existing functional gastrointestinal disorders may also lead to malnutrition. Presence of compromised gastrointestinal function in malnourished children is critical given that alterations such as malabsorption and increased intestinal permeability directly interfere with efficacy of nutritional support and recovery from malnutrition. Appropriate nutritional intervention is the key step in the management of malnutrition, while alterations in gastrointestinal functions in malnourished children are likely even in those with mild degree malnutrition. Therefore, nutritional therapy in children with compromised gastrointestinal function is considered to involve gut-protective interventions that address the overlapping and interacting effects of diarrhea, enteropathy and malnutrition to improve child survival and developmental potential in the long-term. Peptide-based enteral formulas seem to have clinical applications in malnourished children with compromised gastrointestinal function, given their association with improved gastrointestinal tolerance and absorption, better nitrogen retention/ balance, reduced diarrhea and bacterial translocation, enhanced fat absorption, and maintained/restored gut integrity as compared with free amino acid or whole-protein formulas.
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spelling pubmed-82151072021-06-22 Nutritional Support in Malnourished Children With Compromised Gastrointestinal Function: Utility of Peptide-Based Enteral Therapy Selimoglu, Mukadder Ayse Kansu, Aydan Aydogdu, Sema Sarioglu, Aysugul Alptekin Erdogan, Simge Dalgic, Buket Yuce, Aysel Cullu Cokugras, Fugen Front Pediatr Pediatrics This review focuses on nutritional support in malnourished children with compromised gastrointestinal function addressing the interplay between malnutrition and gastrointestinal dysfunction, and the specific role of peptide-based enteral therapy in pediatric malnutrition. Malnutrition is associated with impaired gut functions such as increased intestinal permeability, malabsorption, and diarrhea, while pre-existing functional gastrointestinal disorders may also lead to malnutrition. Presence of compromised gastrointestinal function in malnourished children is critical given that alterations such as malabsorption and increased intestinal permeability directly interfere with efficacy of nutritional support and recovery from malnutrition. Appropriate nutritional intervention is the key step in the management of malnutrition, while alterations in gastrointestinal functions in malnourished children are likely even in those with mild degree malnutrition. Therefore, nutritional therapy in children with compromised gastrointestinal function is considered to involve gut-protective interventions that address the overlapping and interacting effects of diarrhea, enteropathy and malnutrition to improve child survival and developmental potential in the long-term. Peptide-based enteral formulas seem to have clinical applications in malnourished children with compromised gastrointestinal function, given their association with improved gastrointestinal tolerance and absorption, better nitrogen retention/ balance, reduced diarrhea and bacterial translocation, enhanced fat absorption, and maintained/restored gut integrity as compared with free amino acid or whole-protein formulas. Frontiers Media S.A. 2021-06-07 /pmc/articles/PMC8215107/ /pubmed/34164352 http://dx.doi.org/10.3389/fped.2021.610275 Text en Copyright © 2021 Selimoglu, Kansu, Aydogdu, Sarioglu, Erdogan, Dalgic, Yuce and Cullu Cokugras. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pediatrics
Selimoglu, Mukadder Ayse
Kansu, Aydan
Aydogdu, Sema
Sarioglu, Aysugul Alptekin
Erdogan, Simge
Dalgic, Buket
Yuce, Aysel
Cullu Cokugras, Fugen
Nutritional Support in Malnourished Children With Compromised Gastrointestinal Function: Utility of Peptide-Based Enteral Therapy
title Nutritional Support in Malnourished Children With Compromised Gastrointestinal Function: Utility of Peptide-Based Enteral Therapy
title_full Nutritional Support in Malnourished Children With Compromised Gastrointestinal Function: Utility of Peptide-Based Enteral Therapy
title_fullStr Nutritional Support in Malnourished Children With Compromised Gastrointestinal Function: Utility of Peptide-Based Enteral Therapy
title_full_unstemmed Nutritional Support in Malnourished Children With Compromised Gastrointestinal Function: Utility of Peptide-Based Enteral Therapy
title_short Nutritional Support in Malnourished Children With Compromised Gastrointestinal Function: Utility of Peptide-Based Enteral Therapy
title_sort nutritional support in malnourished children with compromised gastrointestinal function: utility of peptide-based enteral therapy
topic Pediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8215107/
https://www.ncbi.nlm.nih.gov/pubmed/34164352
http://dx.doi.org/10.3389/fped.2021.610275
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