mTORC2 regulates ribonucleotide reductase to promote DNA replication and gemcitabine resistance in non-small cell lung cancer()()

Ribonucleotide reductase (RNR) is the key enzyme that catalyzes the production of deoxyribonucleotides (dNTPs) for DNA replication and it is also essential for cancer cell proliferation. As the RNR inhibitor, Gemcitabine is widely used in cancer therapies, however, resistance limits its therapeutic...

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Detalles Bibliográficos
Autores principales: Tian, Ling, Chen, Congcong, Guo, Yanguan, Zhang, Fan, Mi, Jinye, Feng, Qi, Lin, Shengbin, Xi, Naite, Tian, Jiaxin, Yu, Li, Chen, Yan, Cao, Mingrong, Lai, Caiyong, Fan, Jun, Zhang, Yongchang, Chen, Guo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8215139/
https://www.ncbi.nlm.nih.gov/pubmed/34126361
http://dx.doi.org/10.1016/j.neo.2021.05.007

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