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Reversal of motor-skill transfer impairment by trihexyphenidyl and reduction of dorsolateral striatal cholinergic interneurons in Dyt1 ΔGAG knock-in mice
DYT-TOR1A or DYT1 early-onset generalized dystonia is an inherited movement disorder characterized by sustained muscle contractions causing twisting, repetitive movements, or abnormal postures. The majority of the DYT1 dystonia patients have a trinucleotide GAG deletion in DYT1/TOR1A. Trihexyphenidy...
Autores principales: | Yokoi, Fumiaki, Dang, Mai Tu, Zhang, Lin, Dexter, Kelly M., Efimenko, Iakov, Krishnaswamy, Shiv, Villanueva, Matthew, Misztal, Carly I., Gerard, Malinda, Lynch, Patrick, Li, Yuqing |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8215213/ https://www.ncbi.nlm.nih.gov/pubmed/34189496 http://dx.doi.org/10.1016/j.ibneur.2021.05.003 |
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