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Impact of respiratory distress syndrome and birth asphyxia exposure on the survival of preterm neonates in East Africa continent: systematic review and meta-analysis

INTRODUCTION: Several kinds of researches are available on preterm mortality in the East Africa continent; however, it is inconsistent and inconclusive, which requires the pooled evidence to recognize the burden in general. PURPOSE: To collect and synthesis evidence on preterm mortality and identify...

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Autores principales: Chanie, Ermias Sisay, Alemu, Abebew Yeshambel, Mekonen, Demewoze Kefale, Melese, Biruk Demissie, Minuye, Binyam, Hailemeskel, Habtamu Shimels, Asferie, Worku Necho, Bayih, Wubet Alebachew, Munye, Tigabu, Birlie, Tekalign Amera, Amare, Abraham Tsedalu, Tibebu, Nigusie Selomon, Tiruneh, Chalie Marew, Legas, Getasew, Gebre Eyesus, Fisha Alebel, Belay, Demeke Mesfin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8215220/
https://www.ncbi.nlm.nih.gov/pubmed/34189307
http://dx.doi.org/10.1016/j.heliyon.2021.e07256
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author Chanie, Ermias Sisay
Alemu, Abebew Yeshambel
Mekonen, Demewoze Kefale
Melese, Biruk Demissie
Minuye, Binyam
Hailemeskel, Habtamu Shimels
Asferie, Worku Necho
Bayih, Wubet Alebachew
Munye, Tigabu
Birlie, Tekalign Amera
Amare, Abraham Tsedalu
Tibebu, Nigusie Selomon
Tiruneh, Chalie Marew
Legas, Getasew
Gebre Eyesus, Fisha Alebel
Belay, Demeke Mesfin
author_facet Chanie, Ermias Sisay
Alemu, Abebew Yeshambel
Mekonen, Demewoze Kefale
Melese, Biruk Demissie
Minuye, Binyam
Hailemeskel, Habtamu Shimels
Asferie, Worku Necho
Bayih, Wubet Alebachew
Munye, Tigabu
Birlie, Tekalign Amera
Amare, Abraham Tsedalu
Tibebu, Nigusie Selomon
Tiruneh, Chalie Marew
Legas, Getasew
Gebre Eyesus, Fisha Alebel
Belay, Demeke Mesfin
author_sort Chanie, Ermias Sisay
collection PubMed
description INTRODUCTION: Several kinds of researches are available on preterm mortality in the East Africa continent; however, it is inconsistent and inconclusive, which requires the pooled evidence to recognize the burden in general. PURPOSE: To collect and synthesis evidence on preterm mortality and identify factors in the East Africa continent. METHODS: PubMed, Google Scholar, Hinary, Cochrane library, research gate, and institutional repositories were retrieved to identity eligible articles through Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) guidelines. The articles were selected if the publication period is between 2010-2021 G.C. Data were extracted by a standardized JBI data extraction format for mortality rate and stratified the associated factors. Then exported to STATA 14 for further analysis. I(2) and Egger's tests were employed to estimate the heterogeneity and publication bias respectively. Subgroup analysis based on country, study design, year of publication, and the sample size was also examined. RESULT: This meta-analysis included 32 articles with a total of 21,405 study participants. The pooled mortality rate among preterm in the East Africa continent was found to be 19.2% (95% CI (confidence interval (16.0–22.4)). Regarding the study design, the mortality rate was found to be 18.1%, 19.4%, and 19.7% concerning the prospective cohort, retrospective cohort, and cross-sectional studies. The pooled odds of mortality among preterm with respiratory distress syndrome decreased survival by nearly three folds [AOR (Adjusted odds ratio = 3.2; 95% CI: 22, 4.6)] as compared to their counterparts. Similarly, preterm neonates presented with birth asphyxia were nearly three times higher in death as compared with preterm without birth asphyxia [AOR = 2.6; 95% CI: 1.9, 3.4]. CONCLUSION: Preterm mortality was found to be unacceptably high in Eastern Africa continent. Fortunately, the main causes of death were found to be respiratory distress syndrome and birth asphyxia which are preventable and treatable hence early detection and timely management of this problem are highly recommended to improve preterm survival.
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spelling pubmed-82152202021-06-28 Impact of respiratory distress syndrome and birth asphyxia exposure on the survival of preterm neonates in East Africa continent: systematic review and meta-analysis Chanie, Ermias Sisay Alemu, Abebew Yeshambel Mekonen, Demewoze Kefale Melese, Biruk Demissie Minuye, Binyam Hailemeskel, Habtamu Shimels Asferie, Worku Necho Bayih, Wubet Alebachew Munye, Tigabu Birlie, Tekalign Amera Amare, Abraham Tsedalu Tibebu, Nigusie Selomon Tiruneh, Chalie Marew Legas, Getasew Gebre Eyesus, Fisha Alebel Belay, Demeke Mesfin Heliyon Research Article INTRODUCTION: Several kinds of researches are available on preterm mortality in the East Africa continent; however, it is inconsistent and inconclusive, which requires the pooled evidence to recognize the burden in general. PURPOSE: To collect and synthesis evidence on preterm mortality and identify factors in the East Africa continent. METHODS: PubMed, Google Scholar, Hinary, Cochrane library, research gate, and institutional repositories were retrieved to identity eligible articles through Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) guidelines. The articles were selected if the publication period is between 2010-2021 G.C. Data were extracted by a standardized JBI data extraction format for mortality rate and stratified the associated factors. Then exported to STATA 14 for further analysis. I(2) and Egger's tests were employed to estimate the heterogeneity and publication bias respectively. Subgroup analysis based on country, study design, year of publication, and the sample size was also examined. RESULT: This meta-analysis included 32 articles with a total of 21,405 study participants. The pooled mortality rate among preterm in the East Africa continent was found to be 19.2% (95% CI (confidence interval (16.0–22.4)). Regarding the study design, the mortality rate was found to be 18.1%, 19.4%, and 19.7% concerning the prospective cohort, retrospective cohort, and cross-sectional studies. The pooled odds of mortality among preterm with respiratory distress syndrome decreased survival by nearly three folds [AOR (Adjusted odds ratio = 3.2; 95% CI: 22, 4.6)] as compared to their counterparts. Similarly, preterm neonates presented with birth asphyxia were nearly three times higher in death as compared with preterm without birth asphyxia [AOR = 2.6; 95% CI: 1.9, 3.4]. CONCLUSION: Preterm mortality was found to be unacceptably high in Eastern Africa continent. Fortunately, the main causes of death were found to be respiratory distress syndrome and birth asphyxia which are preventable and treatable hence early detection and timely management of this problem are highly recommended to improve preterm survival. Elsevier 2021-06-08 /pmc/articles/PMC8215220/ /pubmed/34189307 http://dx.doi.org/10.1016/j.heliyon.2021.e07256 Text en © 2021 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Research Article
Chanie, Ermias Sisay
Alemu, Abebew Yeshambel
Mekonen, Demewoze Kefale
Melese, Biruk Demissie
Minuye, Binyam
Hailemeskel, Habtamu Shimels
Asferie, Worku Necho
Bayih, Wubet Alebachew
Munye, Tigabu
Birlie, Tekalign Amera
Amare, Abraham Tsedalu
Tibebu, Nigusie Selomon
Tiruneh, Chalie Marew
Legas, Getasew
Gebre Eyesus, Fisha Alebel
Belay, Demeke Mesfin
Impact of respiratory distress syndrome and birth asphyxia exposure on the survival of preterm neonates in East Africa continent: systematic review and meta-analysis
title Impact of respiratory distress syndrome and birth asphyxia exposure on the survival of preterm neonates in East Africa continent: systematic review and meta-analysis
title_full Impact of respiratory distress syndrome and birth asphyxia exposure on the survival of preterm neonates in East Africa continent: systematic review and meta-analysis
title_fullStr Impact of respiratory distress syndrome and birth asphyxia exposure on the survival of preterm neonates in East Africa continent: systematic review and meta-analysis
title_full_unstemmed Impact of respiratory distress syndrome and birth asphyxia exposure on the survival of preterm neonates in East Africa continent: systematic review and meta-analysis
title_short Impact of respiratory distress syndrome and birth asphyxia exposure on the survival of preterm neonates in East Africa continent: systematic review and meta-analysis
title_sort impact of respiratory distress syndrome and birth asphyxia exposure on the survival of preterm neonates in east africa continent: systematic review and meta-analysis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8215220/
https://www.ncbi.nlm.nih.gov/pubmed/34189307
http://dx.doi.org/10.1016/j.heliyon.2021.e07256
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