Functional impact of intramolecular cleavage and dissociation of adhesion G protein–coupled receptor GPR133 (ADGRD1) on canonical signaling

GPR133 (ADGRD1), an adhesion G protein–coupled receptor (GPCR) whose canonical signaling activates G(αS)-mediated generation of cytosolic cAMP, has been shown to be necessary for the growth of glioblastoma (GBM), a brain malignancy. The extracellular N terminus of GPR133 is thought to be autoproteol...

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Detalles Bibliográficos
Autores principales: Frenster, Joshua D., Stephan, Gabriele, Ravn-Boess, Niklas, Bready, Devin, Wilcox, Jordan, Kieslich, Bjoern, Wilde, Caroline, Sträter, Norbert, Wiggin, Giselle R., Liebscher, Ines, Schöneberg, Torsten, Placantonakis, Dimitris G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8215292/
https://www.ncbi.nlm.nih.gov/pubmed/34022221
http://dx.doi.org/10.1016/j.jbc.2021.100798

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