Gβγ translocation to the Golgi apparatus activates ARF1 to spatiotemporally regulate G protein–coupled receptor signaling to MAPK

After activation of G protein–coupled receptors, G protein βγ dimers may translocate from the plasma membrane to the Golgi apparatus (GA). We recently report that this translocation activates extracellular signal–regulated protein kinases 1 and 2 (ERK1/2) via PI3Kγ; however, how Gβγ–PI3Kγ activates...

Descripción completa

Detalles Bibliográficos
Autores principales: Khater, Mostafa, Bryant, Christian N., Wu, Guangyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8215300/
https://www.ncbi.nlm.nih.gov/pubmed/34022220
http://dx.doi.org/10.1016/j.jbc.2021.100805

Ejemplares similares

Ejemplares similares