Comparison of genome-wide gene expression profiling by RNA Sequencing versus microarray in bronchial biopsies of COPD patients before and after inhaled corticosteroid treatment: does it provide new insights?

More DEGs are detected by RNA-Seq than microarrays in COPD lung biopsies and are associated with immunological pathways. Performing bulk tissue cell-type deconvolution in microarray lung samples, using the SVR method, reflects RNA-Seq results. https://bit.ly/2N8sY3s

Detalles Bibliográficos
Autores principales: Ditz, Benedikt, Boekhoudt, Jeunard G., Aliee, Hananeh, Theis, Fabian J., Nawijn, Martijn, Brandsma, Corry-Anke, Hiemstra, Pieter S., Timens, Wim, Tew, Gaik W., Grimbaldeston, Michele A., Neighbors, Margaret, Guryev, Victor, van den Berge, Maarten, Faiz, Alen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Respiratory Society 2021
Materias:
Original Research Letters
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8215328/
https://www.ncbi.nlm.nih.gov/pubmed/34164552
http://dx.doi.org/10.1183/23120541.00104-2021
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author Ditz, Benedikt
Boekhoudt, Jeunard G.
Aliee, Hananeh
Theis, Fabian J.
Nawijn, Martijn
Brandsma, Corry-Anke
Hiemstra, Pieter S.
Timens, Wim
Tew, Gaik W.
Grimbaldeston, Michele A.
Neighbors, Margaret
Guryev, Victor
van den Berge, Maarten
Faiz, Alen
author_facet Ditz, Benedikt
Boekhoudt, Jeunard G.
Aliee, Hananeh
Theis, Fabian J.
Nawijn, Martijn
Brandsma, Corry-Anke
Hiemstra, Pieter S.
Timens, Wim
Tew, Gaik W.
Grimbaldeston, Michele A.
Neighbors, Margaret
Guryev, Victor
van den Berge, Maarten
Faiz, Alen
author_sort Ditz, Benedikt
collection PubMed
description More DEGs are detected by RNA-Seq than microarrays in COPD lung biopsies and are associated with immunological pathways. Performing bulk tissue cell-type deconvolution in microarray lung samples, using the SVR method, reflects RNA-Seq results. https://bit.ly/2N8sY3s
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spelling pubmed-82153282021-06-22 Comparison of genome-wide gene expression profiling by RNA Sequencing versus microarray in bronchial biopsies of COPD patients before and after inhaled corticosteroid treatment: does it provide new insights? Ditz, Benedikt Boekhoudt, Jeunard G. Aliee, Hananeh Theis, Fabian J. Nawijn, Martijn Brandsma, Corry-Anke Hiemstra, Pieter S. Timens, Wim Tew, Gaik W. Grimbaldeston, Michele A. Neighbors, Margaret Guryev, Victor van den Berge, Maarten Faiz, Alen ERJ Open Res Original Research Letters More DEGs are detected by RNA-Seq than microarrays in COPD lung biopsies and are associated with immunological pathways. Performing bulk tissue cell-type deconvolution in microarray lung samples, using the SVR method, reflects RNA-Seq results. https://bit.ly/2N8sY3s European Respiratory Society 2021-06-21 /pmc/articles/PMC8215328/ /pubmed/34164552 http://dx.doi.org/10.1183/23120541.00104-2021 Text en Copyright ©The authors 2021 https://creativecommons.org/licenses/by-nc/4.0/This version is distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0. For commercial reproduction rights and permissions contact permissions@ersnet.org (mailto:permissions@ersnet.org)
spellingShingle Original Research Letters
Ditz, Benedikt
Boekhoudt, Jeunard G.
Aliee, Hananeh
Theis, Fabian J.
Nawijn, Martijn
Brandsma, Corry-Anke
Hiemstra, Pieter S.
Timens, Wim
Tew, Gaik W.
Grimbaldeston, Michele A.
Neighbors, Margaret
Guryev, Victor
van den Berge, Maarten
Faiz, Alen
Comparison of genome-wide gene expression profiling by RNA Sequencing versus microarray in bronchial biopsies of COPD patients before and after inhaled corticosteroid treatment: does it provide new insights?
title Comparison of genome-wide gene expression profiling by RNA Sequencing versus microarray in bronchial biopsies of COPD patients before and after inhaled corticosteroid treatment: does it provide new insights?
title_full Comparison of genome-wide gene expression profiling by RNA Sequencing versus microarray in bronchial biopsies of COPD patients before and after inhaled corticosteroid treatment: does it provide new insights?
title_fullStr Comparison of genome-wide gene expression profiling by RNA Sequencing versus microarray in bronchial biopsies of COPD patients before and after inhaled corticosteroid treatment: does it provide new insights?
title_full_unstemmed Comparison of genome-wide gene expression profiling by RNA Sequencing versus microarray in bronchial biopsies of COPD patients before and after inhaled corticosteroid treatment: does it provide new insights?
title_short Comparison of genome-wide gene expression profiling by RNA Sequencing versus microarray in bronchial biopsies of COPD patients before and after inhaled corticosteroid treatment: does it provide new insights?
title_sort comparison of genome-wide gene expression profiling by rna sequencing versus microarray in bronchial biopsies of copd patients before and after inhaled corticosteroid treatment: does it provide new insights?
topic Original Research Letters
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8215328/
https://www.ncbi.nlm.nih.gov/pubmed/34164552
http://dx.doi.org/10.1183/23120541.00104-2021
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