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Comparison of genome-wide gene expression profiling by RNA Sequencing versus microarray in bronchial biopsies of COPD patients before and after inhaled corticosteroid treatment: does it provide new insights?
More DEGs are detected by RNA-Seq than microarrays in COPD lung biopsies and are associated with immunological pathways. Performing bulk tissue cell-type deconvolution in microarray lung samples, using the SVR method, reflects RNA-Seq results. https://bit.ly/2N8sY3s
Autores principales: | Ditz, Benedikt, Boekhoudt, Jeunard G., Aliee, Hananeh, Theis, Fabian J., Nawijn, Martijn, Brandsma, Corry-Anke, Hiemstra, Pieter S., Timens, Wim, Tew, Gaik W., Grimbaldeston, Michele A., Neighbors, Margaret, Guryev, Victor, van den Berge, Maarten, Faiz, Alen |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
European Respiratory Society
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8215328/ https://www.ncbi.nlm.nih.gov/pubmed/34164552 http://dx.doi.org/10.1183/23120541.00104-2021 |
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