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Post-COVID Opsoclonus Myoclonus Syndrome: A Case Report From Pakistan

Background: Coronavirus disease-2019 (COVID-19), caused by the severe acute respiratory distress syndrome–coronavirus-2 (SARS-CoV-2), is primarily a respiratory infection but has been recently associated with a variety of neurological symptoms. We present herewith a COVID-19 case manifesting as opso...

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Autores principales: Ishaq, Hira, Durrani, Talha, Umar, Zainab, Khan, Nemat, McCombe, Pamela, Ul Haq, Mian Ayaz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8215346/
https://www.ncbi.nlm.nih.gov/pubmed/34163427
http://dx.doi.org/10.3389/fneur.2021.672524
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author Ishaq, Hira
Durrani, Talha
Umar, Zainab
Khan, Nemat
McCombe, Pamela
Ul Haq, Mian Ayaz
author_facet Ishaq, Hira
Durrani, Talha
Umar, Zainab
Khan, Nemat
McCombe, Pamela
Ul Haq, Mian Ayaz
author_sort Ishaq, Hira
collection PubMed
description Background: Coronavirus disease-2019 (COVID-19), caused by the severe acute respiratory distress syndrome–coronavirus-2 (SARS-CoV-2), is primarily a respiratory infection but has been recently associated with a variety of neurological symptoms. We present herewith a COVID-19 case manifesting as opsoclonus-myoclonus syndrome (OMS), a rare neurological disorder. Case Presentation: A 63-year-old male diagnosed with COVID-19 infection developed behavioral changes, confusion, and insomnia followed by reduced mobility and abnormal eye movements within 48 h of recovery from respiratory symptoms associated with COVID-19. On examination, he had rapid, chaotic, involuntary saccadic, multidirectional eye movements (opsoclonus), and limb myoclonus together with truncal ataxia. CSF analysis, MRI of the brain, and screening for anti-neuronal and encephalitis related antibodies were negative. Extensive testing revealed no underlying malignancy. The patient was successfully treated with intravenous immunoglobulin (IVIG) with complete resolution of symptoms within 4 weeks of treatment. Conclusion: COVID-19 infection can be associated with the manifestation of opsoclonus myoclonus syndrome, a rare neurological disorder that can be treated with IVIG if not responsive to corticosteroids.
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spelling pubmed-82153462021-06-22 Post-COVID Opsoclonus Myoclonus Syndrome: A Case Report From Pakistan Ishaq, Hira Durrani, Talha Umar, Zainab Khan, Nemat McCombe, Pamela Ul Haq, Mian Ayaz Front Neurol Neurology Background: Coronavirus disease-2019 (COVID-19), caused by the severe acute respiratory distress syndrome–coronavirus-2 (SARS-CoV-2), is primarily a respiratory infection but has been recently associated with a variety of neurological symptoms. We present herewith a COVID-19 case manifesting as opsoclonus-myoclonus syndrome (OMS), a rare neurological disorder. Case Presentation: A 63-year-old male diagnosed with COVID-19 infection developed behavioral changes, confusion, and insomnia followed by reduced mobility and abnormal eye movements within 48 h of recovery from respiratory symptoms associated with COVID-19. On examination, he had rapid, chaotic, involuntary saccadic, multidirectional eye movements (opsoclonus), and limb myoclonus together with truncal ataxia. CSF analysis, MRI of the brain, and screening for anti-neuronal and encephalitis related antibodies were negative. Extensive testing revealed no underlying malignancy. The patient was successfully treated with intravenous immunoglobulin (IVIG) with complete resolution of symptoms within 4 weeks of treatment. Conclusion: COVID-19 infection can be associated with the manifestation of opsoclonus myoclonus syndrome, a rare neurological disorder that can be treated with IVIG if not responsive to corticosteroids. Frontiers Media S.A. 2021-06-07 /pmc/articles/PMC8215346/ /pubmed/34163427 http://dx.doi.org/10.3389/fneur.2021.672524 Text en Copyright © 2021 Ishaq, Durrani, Umar, Khan, McCombe and Ul Haq. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Ishaq, Hira
Durrani, Talha
Umar, Zainab
Khan, Nemat
McCombe, Pamela
Ul Haq, Mian Ayaz
Post-COVID Opsoclonus Myoclonus Syndrome: A Case Report From Pakistan
title Post-COVID Opsoclonus Myoclonus Syndrome: A Case Report From Pakistan
title_full Post-COVID Opsoclonus Myoclonus Syndrome: A Case Report From Pakistan
title_fullStr Post-COVID Opsoclonus Myoclonus Syndrome: A Case Report From Pakistan
title_full_unstemmed Post-COVID Opsoclonus Myoclonus Syndrome: A Case Report From Pakistan
title_short Post-COVID Opsoclonus Myoclonus Syndrome: A Case Report From Pakistan
title_sort post-covid opsoclonus myoclonus syndrome: a case report from pakistan
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8215346/
https://www.ncbi.nlm.nih.gov/pubmed/34163427
http://dx.doi.org/10.3389/fneur.2021.672524
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