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Pulmonary Edema in COVID-19 Patients: Mechanisms and Treatment Potential
COVID-19 mortality is primarily driven by abnormal alveolar fluid metabolism of the lung, leading to fluid accumulation in the alveolar airspace. This condition is generally referred to as pulmonary edema and is a direct consequence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) inf...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8215379/ https://www.ncbi.nlm.nih.gov/pubmed/34163357 http://dx.doi.org/10.3389/fphar.2021.664349 |
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author | Cui, Xinyu Chen, Wuyue Zhou, Haoyan Gong, Yuan Zhu, Bowen Lv, Xiang Guo, Hongbo Duan, Jinao Zhou, Jing Marcon, Edyta Ma, Hongyue |
author_facet | Cui, Xinyu Chen, Wuyue Zhou, Haoyan Gong, Yuan Zhu, Bowen Lv, Xiang Guo, Hongbo Duan, Jinao Zhou, Jing Marcon, Edyta Ma, Hongyue |
author_sort | Cui, Xinyu |
collection | PubMed |
description | COVID-19 mortality is primarily driven by abnormal alveolar fluid metabolism of the lung, leading to fluid accumulation in the alveolar airspace. This condition is generally referred to as pulmonary edema and is a direct consequence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. There are multiple potential mechanisms leading to pulmonary edema in severe Coronavirus Disease (COVID-19) patients and understanding of those mechanisms may enable proper management of this condition. Here, we provide a perspective on abnormal lung humoral metabolism of pulmonary edema in COVID-19 patients, review the mechanisms by which pulmonary edema may be induced in COVID-19 patients, and propose putative drug targets that may be of use in treating COVID-19. Among the currently pursued therapeutic strategies against COVID-19, little attention has been paid to abnormal lung humoral metabolism. Perplexingly, successful balance of lung humoral metabolism may lead to the reduction of the number of COVID-19 death limiting the possibility of healthcare services with insufficient capacity to provide ventilator-assisted respiration. |
format | Online Article Text |
id | pubmed-8215379 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-82153792021-06-22 Pulmonary Edema in COVID-19 Patients: Mechanisms and Treatment Potential Cui, Xinyu Chen, Wuyue Zhou, Haoyan Gong, Yuan Zhu, Bowen Lv, Xiang Guo, Hongbo Duan, Jinao Zhou, Jing Marcon, Edyta Ma, Hongyue Front Pharmacol Pharmacology COVID-19 mortality is primarily driven by abnormal alveolar fluid metabolism of the lung, leading to fluid accumulation in the alveolar airspace. This condition is generally referred to as pulmonary edema and is a direct consequence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. There are multiple potential mechanisms leading to pulmonary edema in severe Coronavirus Disease (COVID-19) patients and understanding of those mechanisms may enable proper management of this condition. Here, we provide a perspective on abnormal lung humoral metabolism of pulmonary edema in COVID-19 patients, review the mechanisms by which pulmonary edema may be induced in COVID-19 patients, and propose putative drug targets that may be of use in treating COVID-19. Among the currently pursued therapeutic strategies against COVID-19, little attention has been paid to abnormal lung humoral metabolism. Perplexingly, successful balance of lung humoral metabolism may lead to the reduction of the number of COVID-19 death limiting the possibility of healthcare services with insufficient capacity to provide ventilator-assisted respiration. Frontiers Media S.A. 2021-06-07 /pmc/articles/PMC8215379/ /pubmed/34163357 http://dx.doi.org/10.3389/fphar.2021.664349 Text en Copyright © 2021 Cui, Chen, Zhou, Gong, Zhu, Lv, Guo, Duan, Zhou, Marcon and Ma. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pharmacology Cui, Xinyu Chen, Wuyue Zhou, Haoyan Gong, Yuan Zhu, Bowen Lv, Xiang Guo, Hongbo Duan, Jinao Zhou, Jing Marcon, Edyta Ma, Hongyue Pulmonary Edema in COVID-19 Patients: Mechanisms and Treatment Potential |
title | Pulmonary Edema in COVID-19 Patients: Mechanisms and Treatment Potential |
title_full | Pulmonary Edema in COVID-19 Patients: Mechanisms and Treatment Potential |
title_fullStr | Pulmonary Edema in COVID-19 Patients: Mechanisms and Treatment Potential |
title_full_unstemmed | Pulmonary Edema in COVID-19 Patients: Mechanisms and Treatment Potential |
title_short | Pulmonary Edema in COVID-19 Patients: Mechanisms and Treatment Potential |
title_sort | pulmonary edema in covid-19 patients: mechanisms and treatment potential |
topic | Pharmacology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8215379/ https://www.ncbi.nlm.nih.gov/pubmed/34163357 http://dx.doi.org/10.3389/fphar.2021.664349 |
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