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Pulmonary Edema in COVID-19 Patients: Mechanisms and Treatment Potential

COVID-19 mortality is primarily driven by abnormal alveolar fluid metabolism of the lung, leading to fluid accumulation in the alveolar airspace. This condition is generally referred to as pulmonary edema and is a direct consequence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) inf...

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Autores principales: Cui, Xinyu, Chen, Wuyue, Zhou, Haoyan, Gong, Yuan, Zhu, Bowen, Lv, Xiang, Guo, Hongbo, Duan, Jinao, Zhou, Jing, Marcon, Edyta, Ma, Hongyue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8215379/
https://www.ncbi.nlm.nih.gov/pubmed/34163357
http://dx.doi.org/10.3389/fphar.2021.664349
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author Cui, Xinyu
Chen, Wuyue
Zhou, Haoyan
Gong, Yuan
Zhu, Bowen
Lv, Xiang
Guo, Hongbo
Duan, Jinao
Zhou, Jing
Marcon, Edyta
Ma, Hongyue
author_facet Cui, Xinyu
Chen, Wuyue
Zhou, Haoyan
Gong, Yuan
Zhu, Bowen
Lv, Xiang
Guo, Hongbo
Duan, Jinao
Zhou, Jing
Marcon, Edyta
Ma, Hongyue
author_sort Cui, Xinyu
collection PubMed
description COVID-19 mortality is primarily driven by abnormal alveolar fluid metabolism of the lung, leading to fluid accumulation in the alveolar airspace. This condition is generally referred to as pulmonary edema and is a direct consequence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. There are multiple potential mechanisms leading to pulmonary edema in severe Coronavirus Disease (COVID-19) patients and understanding of those mechanisms may enable proper management of this condition. Here, we provide a perspective on abnormal lung humoral metabolism of pulmonary edema in COVID-19 patients, review the mechanisms by which pulmonary edema may be induced in COVID-19 patients, and propose putative drug targets that may be of use in treating COVID-19. Among the currently pursued therapeutic strategies against COVID-19, little attention has been paid to abnormal lung humoral metabolism. Perplexingly, successful balance of lung humoral metabolism may lead to the reduction of the number of COVID-19 death limiting the possibility of healthcare services with insufficient capacity to provide ventilator-assisted respiration.
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spelling pubmed-82153792021-06-22 Pulmonary Edema in COVID-19 Patients: Mechanisms and Treatment Potential Cui, Xinyu Chen, Wuyue Zhou, Haoyan Gong, Yuan Zhu, Bowen Lv, Xiang Guo, Hongbo Duan, Jinao Zhou, Jing Marcon, Edyta Ma, Hongyue Front Pharmacol Pharmacology COVID-19 mortality is primarily driven by abnormal alveolar fluid metabolism of the lung, leading to fluid accumulation in the alveolar airspace. This condition is generally referred to as pulmonary edema and is a direct consequence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. There are multiple potential mechanisms leading to pulmonary edema in severe Coronavirus Disease (COVID-19) patients and understanding of those mechanisms may enable proper management of this condition. Here, we provide a perspective on abnormal lung humoral metabolism of pulmonary edema in COVID-19 patients, review the mechanisms by which pulmonary edema may be induced in COVID-19 patients, and propose putative drug targets that may be of use in treating COVID-19. Among the currently pursued therapeutic strategies against COVID-19, little attention has been paid to abnormal lung humoral metabolism. Perplexingly, successful balance of lung humoral metabolism may lead to the reduction of the number of COVID-19 death limiting the possibility of healthcare services with insufficient capacity to provide ventilator-assisted respiration. Frontiers Media S.A. 2021-06-07 /pmc/articles/PMC8215379/ /pubmed/34163357 http://dx.doi.org/10.3389/fphar.2021.664349 Text en Copyright © 2021 Cui, Chen, Zhou, Gong, Zhu, Lv, Guo, Duan, Zhou, Marcon and Ma. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Cui, Xinyu
Chen, Wuyue
Zhou, Haoyan
Gong, Yuan
Zhu, Bowen
Lv, Xiang
Guo, Hongbo
Duan, Jinao
Zhou, Jing
Marcon, Edyta
Ma, Hongyue
Pulmonary Edema in COVID-19 Patients: Mechanisms and Treatment Potential
title Pulmonary Edema in COVID-19 Patients: Mechanisms and Treatment Potential
title_full Pulmonary Edema in COVID-19 Patients: Mechanisms and Treatment Potential
title_fullStr Pulmonary Edema in COVID-19 Patients: Mechanisms and Treatment Potential
title_full_unstemmed Pulmonary Edema in COVID-19 Patients: Mechanisms and Treatment Potential
title_short Pulmonary Edema in COVID-19 Patients: Mechanisms and Treatment Potential
title_sort pulmonary edema in covid-19 patients: mechanisms and treatment potential
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8215379/
https://www.ncbi.nlm.nih.gov/pubmed/34163357
http://dx.doi.org/10.3389/fphar.2021.664349
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