Cargando…

Design of a Proteolytically Stable Sodium-Calcium Exchanger 1 Activator Peptide for In Vivo Studies

The cardiac sodium–calcium exchanger (NCX1) is important for normal Na(+)- and Ca(2+)-homeostasis and cardiomyocyte relaxation and contraction. It has been suggested that NCX1 activity is reduced by phosphorylated phospholemman (pSer68-PLM); however its direct interaction with PLM is debated. Disrup...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wanichawan, Pimthanya, Skogestad, Jonas, Lunde, Marianne, Støle, Thea Parsberg, Stensland, Maria, Nyman, Tuula A., Sjaastad, Ivar, Sejersted, Ole M., Aronsen, Jan Magnus, Carlson, Cathrine Rein
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8215385/ https://www.ncbi.nlm.nih.gov/pubmed/34163352 http://dx.doi.org/10.3389/fphar.2021.638646

Ejemplares similares

Development of a high-affinity peptide that prevents phospholemman (PLM) inhibition of the sodium/calcium exchanger 1 (NCX1)
por: Wanichawan, Pimthanya, et al.
Publicado: (2016)

The female syndecan-4(−/−) heart has smaller cardiomyocytes, augmented insulin/pSer473-Akt/pSer9-GSK-3β signaling, and lowered SCOP, pThr308-Akt/Akt and GLUT4 levels
por: Støle, Thea Parsberg, et al.
Publicado: (2022)

Polyarginine Cell-Penetrating Peptides Bind and Inhibit SERCA2
por: Lunde, Per Kristian, et al.
Publicado: (2023)

Exhausting treadmill running causes dephosphorylation of sMLC2 and reduced level of myofilament MLCK2 in slow twitch rat soleus muscle
por: Hortemo, Kristin Halvorsen, et al.
Publicado: (2015)

Attenuated Fatigue in Slow Twitch Skeletal Muscle during Isotonic Exercise in Rats with Chronic Heart Failure
por: Munkvik, Morten, et al.
Publicado: (2011)

The Cardiac Syndecan-2 Interactome
por: Mathiesen, Sabrina Bech, et al.
Publicado: (2020)

Pentosan Polysulfate Decreases Myocardial Expression of the Extracellular Matrix Enzyme ADAMTS4 and Improves Cardiac Function In Vivo in Rats Subjected to Pressure Overload by Aortic Banding
por: Vistnes, Maria, et al.
Publicado: (2014)

Cardiomyocyte-specific overexpression of syndecan-4 in mice results in activation of calcineurin-NFAT signalling and exacerbated cardiac hypertrophy
por: Lunde, Ida G., et al.
Publicado: (2022)

Syndecan-4(–/–) Mice Have Smaller Muscle Fibers, Increased Akt/mTOR/S6K1 and Notch/HES-1 Pathways, and Alterations in Extracellular Matrix Components
por: Rønning, Sissel Beate, et al.
Publicado: (2020)

Exercise training increases protein O‐GlcNAcylation in rat skeletal muscle
por: Hortemo, Kristin Halvorsen, et al.
Publicado: (2016)

Increased passive stiffness promotes diastolic dysfunction despite improved Ca(2+) handling during left ventricular concentric hypertrophy
por: Røe, Åsmund T., et al.
Publicado: (2017)

Elevated ventricular wall stress disrupts cardiomyocyte t-tubule structure and calcium homeostasis
por: Frisk, Michael, et al.
Publicado: (2016)

Hypokalemia-Induced Arrhythmias and Heart Failure: New Insights and Implications for Therapy
por: Skogestad, Jonas, et al.
Publicado: (2018)

Regulation of Cardiac Contractility by the Alpha 2 Subunit of the Na(+)/K(+)-ATPase
por: Skogestad, Jonas, et al.
Publicado: (2022)

Ryanodine receptor dispersion disrupts Ca(2+) release in failing cardiac myocytes
por: Kolstad, Terje R, et al.
Publicado: (2018)

Hypokalemia Promotes Arrhythmia by Distinct Mechanisms in Atrial and Ventricular Myocytes
por: Tazmini, Kiarash, et al.
Publicado: (2020)

Three-Directional Evaluation of Mitral Flow in the Rat Heart by Phase-Contrast Cardiovascular Magnetic Resonance
por: Skårdal, Kristine, et al.
Publicado: (2016)

Regional diastolic dysfunction in post-infarction heart failure: role of local mechanical load and SERCA expression
por: Røe, Åsmund T, et al.
Publicado: (2019)

Exercise Training Stabilizes RyR2-Dependent Ca(2+) Release in Post-infarction Heart Failure
por: Danielsen, Tore Kristian, et al.
Publicado: (2021)

A c-Myb mutant causes deregulated differentiation due to impaired histone binding and abrogated pioneer factor function
por: Fuglerud, Bettina M., et al.
Publicado: (2017)

Accelerated magnetic resonance imaging tissue phase mapping of the rat myocardium using compressed sensing with iterative soft-thresholding
por: McGinley, Gary, et al.
Publicado: (2019)

Inhibition of the extracellular enzyme A disintegrin and metalloprotease with thrombospondin motif 4 prevents cardiac fibrosis and dysfunction
por: Vistnes, Maria, et al.
Publicado: (2023)

Novel insight into the detailed myocardial motion and deformation of the rodent heart using high-resolution phase contrast cardiovascular magnetic resonance
por: Espe, Emil KS, et al.
Publicado: (2013)

The extracellular matrix proteoglycan fibromodulin is upregulated in clinical and experimental heart failure and affects cardiac remodeling
por: Andenæs, Kine, et al.
Publicado: (2018)

Cyclic GMP generated by natriuretic peptide receptor B enhances β(1)-adrenoceptor signaling in normal and failing hearts
por: Meier, Silja, et al.
Publicado: (2011)

Beta-Adrenoceptor Stimulation Reveals Ca(2+) Waves and Sarcoplasmic Reticulum Ca(2+) Depletion in Left Ventricular Cardiomyocytes from Post-Infarction Rats with and without Heart Failure
por: Sadredini, Mani, et al.
Publicado: (2016)

Sarcoplasmic Reticulum Calcium Release Is Required for Arrhythmogenesis in the Mouse
por: Edwards, Andrew G., et al.
Publicado: (2021)

Compensatory and decompensatory alterations in cardiomyocyte Ca(2+) dynamics in hearts with diastolic dysfunction following aortic banding
por: Gattoni, Sara, et al.
Publicado: (2017)

Agents increasing cyclic GMP amplify 5-HT(4)-elicited positive inotropic response in failing rat cardiac ventricle
por: Afzal, Faraz, et al.
Publicado: (2011)

Multiple Causes of Fatigue during Shortening Contractions in Rat Slow Twitch Skeletal Muscle
por: Hortemo, Kristin Halvorsen, et al.
Publicado: (2013)

Genome-wide profiling of DNA 5-hydroxymethylcytosine during rat Sertoli cell maturation
por: Landfors, Miriam, et al.
Publicado: (2017)

The extracellular matrix proteoglycan lumican improves survival and counteracts cardiac dilatation and failure in mice subjected to pressure overload
por: Mohammadzadeh, Naiyereh, et al.
Publicado: (2019)

Ca(2+)-Clock-Dependent Pacemaking in the Sinus Node Is Impaired in Mice with a Cardiac Specific Reduction in SERCA2 Abundance
por: Logantha, Sunil Jit R. J., et al.
Publicado: (2016)

Enhancement of cAMP-mediated inotropic responses by CNP is regulated differently by PDE2 in normal and failing hearts
por: Meier, Silja, et al.
Publicado: (2015)

Erratum: Design of a Proteolytically Stable Sodium-Calcium Exchanger 1 Activator Peptide for In Vivo Studies
por: Frontiers Production Office,
Publicado: (2021)

The mechanism of CNP-induced negative inotropic and positive lusitropic responses are dependent on SERCA activity in failing rat ventricle
por: Moltzau, Lise Román, et al.
Publicado: (2011)

Isolation of a cytolytic subpopulation of extracellular vesicles derived from NK cells containing NKG7 and cytolytic proteins
por: Aarsund, Miriam, et al.
Publicado: (2022)

Arrhythmia initiation in catecholaminergic polymorphic ventricular tachycardia type 1 depends on both heart rate and sympathetic stimulation
por: Danielsen, Tore K., et al.
Publicado: (2018)

Proteolytic activity assayed by subcellular localization switching of a substrate
por: Szilvay, Anne-Marie, et al.
Publicado: (2016)

Comparison between articular chondrocytes and mesenchymal stromal cells for the production of articular cartilage implants
por: Frerker, Nadine, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_crrtome7bs0ukv8rpp9ed2qstn