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Neddylation Regulates Macrophages and Implications for Cancer Therapy

Tumor-associated macrophages (TAMs) promote cancer progression via stimulating angiogenesis, invasion/metastasis, and suppressing anti-cancer immunity. Targeting TAMs is a potential promising cancer therapeutic strategy. Neddylation adds the ubiquitin-like protein NEDD8 to substrates, and thereby re...

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Autores principales: Jiang, Yanyu, Li, Lihui, Li, Yan, Liu, Guangwei, Hoffman, Robert M., Jia, Lijun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8215544/
https://www.ncbi.nlm.nih.gov/pubmed/34164400
http://dx.doi.org/10.3389/fcell.2021.681186
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author Jiang, Yanyu
Li, Lihui
Li, Yan
Liu, Guangwei
Hoffman, Robert M.
Jia, Lijun
author_facet Jiang, Yanyu
Li, Lihui
Li, Yan
Liu, Guangwei
Hoffman, Robert M.
Jia, Lijun
author_sort Jiang, Yanyu
collection PubMed
description Tumor-associated macrophages (TAMs) promote cancer progression via stimulating angiogenesis, invasion/metastasis, and suppressing anti-cancer immunity. Targeting TAMs is a potential promising cancer therapeutic strategy. Neddylation adds the ubiquitin-like protein NEDD8 to substrates, and thereby regulates diverse biological processes in multiple cell types, including macrophages. By controlling cellular responses, the neddylation pathway regulates the function, migration, survival, and polarization of macrophages. In the present review we summarized how the neddylation pathway modulates Macrophages and its implications for cancer therapy.
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spelling pubmed-82155442021-06-22 Neddylation Regulates Macrophages and Implications for Cancer Therapy Jiang, Yanyu Li, Lihui Li, Yan Liu, Guangwei Hoffman, Robert M. Jia, Lijun Front Cell Dev Biol Cell and Developmental Biology Tumor-associated macrophages (TAMs) promote cancer progression via stimulating angiogenesis, invasion/metastasis, and suppressing anti-cancer immunity. Targeting TAMs is a potential promising cancer therapeutic strategy. Neddylation adds the ubiquitin-like protein NEDD8 to substrates, and thereby regulates diverse biological processes in multiple cell types, including macrophages. By controlling cellular responses, the neddylation pathway regulates the function, migration, survival, and polarization of macrophages. In the present review we summarized how the neddylation pathway modulates Macrophages and its implications for cancer therapy. Frontiers Media S.A. 2021-06-07 /pmc/articles/PMC8215544/ /pubmed/34164400 http://dx.doi.org/10.3389/fcell.2021.681186 Text en Copyright © 2021 Jiang, Li, Li, Liu, Hoffman and Jia. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Jiang, Yanyu
Li, Lihui
Li, Yan
Liu, Guangwei
Hoffman, Robert M.
Jia, Lijun
Neddylation Regulates Macrophages and Implications for Cancer Therapy
title Neddylation Regulates Macrophages and Implications for Cancer Therapy
title_full Neddylation Regulates Macrophages and Implications for Cancer Therapy
title_fullStr Neddylation Regulates Macrophages and Implications for Cancer Therapy
title_full_unstemmed Neddylation Regulates Macrophages and Implications for Cancer Therapy
title_short Neddylation Regulates Macrophages and Implications for Cancer Therapy
title_sort neddylation regulates macrophages and implications for cancer therapy
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8215544/
https://www.ncbi.nlm.nih.gov/pubmed/34164400
http://dx.doi.org/10.3389/fcell.2021.681186
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