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Long-Term Patient-Centred Follow-up in a Prospective Cohort of Patients with COVID-19

INTRODUCTION: To better define COVID-19 long-term impact we prospectively analysed patient-centred outcomes, including general health and symptom duration. METHODS: Barthel index (BI), St. George’s Respiratory Questionnaire adapted to patients with COVID-19 (aSGRQ) and WHO Clinical Progression Scale...

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Detalles Bibliográficos
Autores principales: Righi, Elda, Mirandola, Massimo, Mazzaferri, Fulvia, Razzaboni, Elisa, Zaffagnini, Amina, Erbogasto, Anna, Vecchia, Ilaria Dalla, Auerbach, Nina, Ivaldi, Federico, Mongardi, Maria, Minuz, Pietro, Milella, Michele, Mehrabi, Sara, Olivieri, Oliviero, Girelli, Domenico, Polati, Enrico, Micheletto, Claudio, Tacconelli, Evelina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Healthcare 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8215633/
https://www.ncbi.nlm.nih.gov/pubmed/34152573
http://dx.doi.org/10.1007/s40121-021-00461-3
Descripción
Sumario:INTRODUCTION: To better define COVID-19 long-term impact we prospectively analysed patient-centred outcomes, including general health and symptom duration. METHODS: Barthel index (BI), St. George’s Respiratory Questionnaire adapted to patients with COVID-19 (aSGRQ) and WHO Clinical Progression Scale (CPS) were measured at enrolment and at 6 weeks from the onset of symptoms. Persistence of most frequently reported symptoms was assessed at 6 weeks and, among symptomatic patients, at 12 weeks from the onset of symptoms. Predictors of impaired general health over time were identified using an ordinal multilevel multivariate model. RESULTS: A total of 448 patients (55% men, median age 56 years) were enrolled. WHO-CPS showed mild, moderate and severe disease in 48%, 42% and 10% of patients at admission and mild disease in all patients at follow-up, respectively. BI and aSGRQ were normal in 96% and 93% patients before COVID-19 but only in 47% and 16% at COVID-19 diagnosis and in 87% and 65% at 6-week follow-up. Male gender was identified by all three assessments as a predictor of impaired general health (BI, OR 2.14, p < 0.0001; aSGRQ, OR 0.53, p = 0.003; WHO-CPS, OR 1.56, p = 0.01). Other predictors included age, ICU admission and comorbidities (e.g. cardiovascular disease and cancer) for BI, hospital admission for aSGRQ, age and presence of comorbidities for WHO-CPS. At 6- and 12-week follow-up, 39% and 20% of patients, respectively, were still reporting symptoms. Fatigue and breathlessness were the most frequently reported symptoms. CONCLUSIONS: Long-term follow-up facilitates the monitoring of health impairment and symptom persistence and can contribute to plan tailored interventions. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s40121-021-00461-3.