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Sizing, stabilising, and cloning repeat-expansions for gene targeting constructs
Aberrant microsatellite repeat-expansions at specific loci within the human genome cause several distinct, heritable, and predominantly neurological, disorders. Creating models for these diseases poses a challenge, due to the instability of such repeats in bacterial vectors, especially with large re...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Academic Press
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8215685/ https://www.ncbi.nlm.nih.gov/pubmed/32721467 http://dx.doi.org/10.1016/j.ymeth.2020.07.007 |