Absence of Non-Canonical, Inhibitory MYD88 Splice Variants in B Cell Lymphomas Correlates With Sustained NF-κB Signaling

Gain-of-function mutations of the TLR adaptor and oncoprotein MyD88 drive B cell lymphomagenesis via sustained NF-κB activation. In myeloid cells, both short and sustained TLR activation and NF-κB activation lead to the induction of inhibitory MYD88 splice variants that restrain prolonged NF-κB acti...

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Detalles Bibliográficos
Autores principales: Cardona Gloria, Yamel, Bernhart, Stephan H., Fillinger, Sven, Wolz, Olaf-Oliver, Dickhöfer, Sabine, Admard, Jakob, Ossowski, Stephan, Nahnsen, Sven, Siebert, Reiner, Weber, Alexander N. R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8215704/
https://www.ncbi.nlm.nih.gov/pubmed/34163463
http://dx.doi.org/10.3389/fimmu.2021.616451

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