Cargando…
The minimal perceived change: a formal model of the responder definition according to the patient’s meaning of change for patient-reported outcome data analysis and interpretation
BACKGROUND: Patient-Reported Outcomes (PROs) are standardized questionnaires used to measure subjective outcomes such as quality of life in healthcare. They are considered paramount to assess the results of therapeutic interventions. However, because their calibration is relative to internal standar...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8215756/ https://www.ncbi.nlm.nih.gov/pubmed/34154521 http://dx.doi.org/10.1186/s12874-021-01307-9 |
_version_ | 1783710301114335232 |
---|---|
author | Vanier, Antoine Sébille, Véronique Blanchin, Myriam Hardouin, Jean-Benoit |
author_facet | Vanier, Antoine Sébille, Véronique Blanchin, Myriam Hardouin, Jean-Benoit |
author_sort | Vanier, Antoine |
collection | PubMed |
description | BACKGROUND: Patient-Reported Outcomes (PROs) are standardized questionnaires used to measure subjective outcomes such as quality of life in healthcare. They are considered paramount to assess the results of therapeutic interventions. However, because their calibration is relative to internal standards in people’s mind, changes in PRO scores are difficult to interpret. Knowing the smallest value in the score that the patient perceives as change can help. An estimator linking the answers to a Patient Global Rating of Change (PGRC: a question measuring the overall feeling of change) with change in PRO scores is frequently used to obtain this value. In the last 30 years, a plethora of methods have been used to obtain these estimates, but there is no consensus on the appropriate method and no formal definition of this value. METHODS: We propose a model to explain changes in PRO scores and PGRC answers. RESULTS: A PGRC measures a construct called the Perceived Change (PC), whose determinants are elicited. Answering a PGRC requires discretizing a continuous PC into a category using threshold values that are random variables. Therefore, the populational value of the Minimal Perceived Change (MPC) is the location parameter value of the threshold on the PC continuum defining the switch from the absence of change to change. CONCLUSIONS: We show how this model can help to hypothesize what are the appropriate methods to estimate the MPC and its potential to be a rigorous theoretical basis for future work on the interpretation of change in PRO scores. |
format | Online Article Text |
id | pubmed-8215756 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-82157562021-06-23 The minimal perceived change: a formal model of the responder definition according to the patient’s meaning of change for patient-reported outcome data analysis and interpretation Vanier, Antoine Sébille, Véronique Blanchin, Myriam Hardouin, Jean-Benoit BMC Med Res Methodol Research Article BACKGROUND: Patient-Reported Outcomes (PROs) are standardized questionnaires used to measure subjective outcomes such as quality of life in healthcare. They are considered paramount to assess the results of therapeutic interventions. However, because their calibration is relative to internal standards in people’s mind, changes in PRO scores are difficult to interpret. Knowing the smallest value in the score that the patient perceives as change can help. An estimator linking the answers to a Patient Global Rating of Change (PGRC: a question measuring the overall feeling of change) with change in PRO scores is frequently used to obtain this value. In the last 30 years, a plethora of methods have been used to obtain these estimates, but there is no consensus on the appropriate method and no formal definition of this value. METHODS: We propose a model to explain changes in PRO scores and PGRC answers. RESULTS: A PGRC measures a construct called the Perceived Change (PC), whose determinants are elicited. Answering a PGRC requires discretizing a continuous PC into a category using threshold values that are random variables. Therefore, the populational value of the Minimal Perceived Change (MPC) is the location parameter value of the threshold on the PC continuum defining the switch from the absence of change to change. CONCLUSIONS: We show how this model can help to hypothesize what are the appropriate methods to estimate the MPC and its potential to be a rigorous theoretical basis for future work on the interpretation of change in PRO scores. BioMed Central 2021-06-21 /pmc/articles/PMC8215756/ /pubmed/34154521 http://dx.doi.org/10.1186/s12874-021-01307-9 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Article Vanier, Antoine Sébille, Véronique Blanchin, Myriam Hardouin, Jean-Benoit The minimal perceived change: a formal model of the responder definition according to the patient’s meaning of change for patient-reported outcome data analysis and interpretation |
title | The minimal perceived change: a formal model of the responder definition according to the patient’s meaning of change for patient-reported outcome data analysis and interpretation |
title_full | The minimal perceived change: a formal model of the responder definition according to the patient’s meaning of change for patient-reported outcome data analysis and interpretation |
title_fullStr | The minimal perceived change: a formal model of the responder definition according to the patient’s meaning of change for patient-reported outcome data analysis and interpretation |
title_full_unstemmed | The minimal perceived change: a formal model of the responder definition according to the patient’s meaning of change for patient-reported outcome data analysis and interpretation |
title_short | The minimal perceived change: a formal model of the responder definition according to the patient’s meaning of change for patient-reported outcome data analysis and interpretation |
title_sort | minimal perceived change: a formal model of the responder definition according to the patient’s meaning of change for patient-reported outcome data analysis and interpretation |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8215756/ https://www.ncbi.nlm.nih.gov/pubmed/34154521 http://dx.doi.org/10.1186/s12874-021-01307-9 |
work_keys_str_mv | AT vanierantoine theminimalperceivedchangeaformalmodeloftheresponderdefinitionaccordingtothepatientsmeaningofchangeforpatientreportedoutcomedataanalysisandinterpretation AT sebilleveronique theminimalperceivedchangeaformalmodeloftheresponderdefinitionaccordingtothepatientsmeaningofchangeforpatientreportedoutcomedataanalysisandinterpretation AT blanchinmyriam theminimalperceivedchangeaformalmodeloftheresponderdefinitionaccordingtothepatientsmeaningofchangeforpatientreportedoutcomedataanalysisandinterpretation AT hardouinjeanbenoit theminimalperceivedchangeaformalmodeloftheresponderdefinitionaccordingtothepatientsmeaningofchangeforpatientreportedoutcomedataanalysisandinterpretation AT vanierantoine minimalperceivedchangeaformalmodeloftheresponderdefinitionaccordingtothepatientsmeaningofchangeforpatientreportedoutcomedataanalysisandinterpretation AT sebilleveronique minimalperceivedchangeaformalmodeloftheresponderdefinitionaccordingtothepatientsmeaningofchangeforpatientreportedoutcomedataanalysisandinterpretation AT blanchinmyriam minimalperceivedchangeaformalmodeloftheresponderdefinitionaccordingtothepatientsmeaningofchangeforpatientreportedoutcomedataanalysisandinterpretation AT hardouinjeanbenoit minimalperceivedchangeaformalmodeloftheresponderdefinitionaccordingtothepatientsmeaningofchangeforpatientreportedoutcomedataanalysisandinterpretation |