Dominance of Methicillin-Resistant Staphylococcus aureus in a Japanese Infant with Recessive Dystrophic Epidermolysis Bullosa

A male infant had the very fragile skin and easily formed bullas by rubbing and scratching from his birth. He was diagnosed with severe recessive dystrophic epidermolysis bullosa (RDEB) due to the lack of type VII collagen by performing an immunofluorescence mapping method from a skin biopsy specime...

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Autores principales: Kondo, Makoto, Takashima, Shota, Goto, Hiroyuki, Habe, Koji, Natsuga, Ken, Yamanaka, Keiichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2021
Materias:
Single Case
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8216027/
https://www.ncbi.nlm.nih.gov/pubmed/34177518
http://dx.doi.org/10.1159/000516354
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author Kondo, Makoto
Takashima, Shota
Goto, Hiroyuki
Habe, Koji
Natsuga, Ken
Yamanaka, Keiichi
author_facet Kondo, Makoto
Takashima, Shota
Goto, Hiroyuki
Habe, Koji
Natsuga, Ken
Yamanaka, Keiichi
author_sort Kondo, Makoto
collection PubMed
description A male infant had the very fragile skin and easily formed bullas by rubbing and scratching from his birth. He was diagnosed with severe recessive dystrophic epidermolysis bullosa (RDEB) due to the lack of type VII collagen by performing an immunofluorescence mapping method from a skin biopsy specimen of the patient's bulla. We analyzed the skin microbiome using next-generation sequencer. The species from the patient's skin revealed the dominance of Staphylococcus aureus (S. aureus) similar to the reports from Austria and Chile severe RDEB patients, and these results are same as the pattern isolated from the skin of atopic dermatitis (AD) patients with flares. The interaction of microbiome and skin microenvironment may be similar between RDEB and AD worldwide.
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spelling pubmed-82160272021-06-25 Dominance of Methicillin-Resistant Staphylococcus aureus in a Japanese Infant with Recessive Dystrophic Epidermolysis Bullosa Kondo, Makoto Takashima, Shota Goto, Hiroyuki Habe, Koji Natsuga, Ken Yamanaka, Keiichi Case Rep Dermatol Single Case A male infant had the very fragile skin and easily formed bullas by rubbing and scratching from his birth. He was diagnosed with severe recessive dystrophic epidermolysis bullosa (RDEB) due to the lack of type VII collagen by performing an immunofluorescence mapping method from a skin biopsy specimen of the patient's bulla. We analyzed the skin microbiome using next-generation sequencer. The species from the patient's skin revealed the dominance of Staphylococcus aureus (S. aureus) similar to the reports from Austria and Chile severe RDEB patients, and these results are same as the pattern isolated from the skin of atopic dermatitis (AD) patients with flares. The interaction of microbiome and skin microenvironment may be similar between RDEB and AD worldwide. S. Karger AG 2021-06-08 /pmc/articles/PMC8216027/ /pubmed/34177518 http://dx.doi.org/10.1159/000516354 Text en Copyright © 2021 by S. Karger AG, Basel https://creativecommons.org/licenses/by-nc/4.0/This article is licensed under the Creative Commons Attribution-NonCommercial-4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission.
spellingShingle Single Case
Kondo, Makoto
Takashima, Shota
Goto, Hiroyuki
Habe, Koji
Natsuga, Ken
Yamanaka, Keiichi
Dominance of Methicillin-Resistant Staphylococcus aureus in a Japanese Infant with Recessive Dystrophic Epidermolysis Bullosa
title Dominance of Methicillin-Resistant Staphylococcus aureus in a Japanese Infant with Recessive Dystrophic Epidermolysis Bullosa
title_full Dominance of Methicillin-Resistant Staphylococcus aureus in a Japanese Infant with Recessive Dystrophic Epidermolysis Bullosa
title_fullStr Dominance of Methicillin-Resistant Staphylococcus aureus in a Japanese Infant with Recessive Dystrophic Epidermolysis Bullosa
title_full_unstemmed Dominance of Methicillin-Resistant Staphylococcus aureus in a Japanese Infant with Recessive Dystrophic Epidermolysis Bullosa
title_short Dominance of Methicillin-Resistant Staphylococcus aureus in a Japanese Infant with Recessive Dystrophic Epidermolysis Bullosa
title_sort dominance of methicillin-resistant staphylococcus aureus in a japanese infant with recessive dystrophic epidermolysis bullosa
topic Single Case
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8216027/
https://www.ncbi.nlm.nih.gov/pubmed/34177518
http://dx.doi.org/10.1159/000516354
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