Therapeutic drug monitoring of olanzapine: Easy and reliable method for clinical correlation

AIM: The current work establishes an easy, reliable technique for the estimation of serum Olanzapine concentration which correlates it clinically. SUBJECTS AND METHODS: The work was agreed in 61 schizophrenic patients who were on olanzapine. Serum drug amount was estimated by normal-phase high-perfo...

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Detalles Bibliográficos
Autores principales: Junutula, Srinivas Pramod, Dubasi, Sai Kiran, Padide, Sai Geethika Reddy, Miryala, Gireesh Kumar, Koppolu, Manasa Soumya, Sheshagiri, Sharvana Bhava Bandaru, Eggadi, Venkateshwarlu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8216114/
https://www.ncbi.nlm.nih.gov/pubmed/33975992
http://dx.doi.org/10.4103/ijp.IJP_114_20
Descripción
Sumario:AIM: The current work establishes an easy, reliable technique for the estimation of serum Olanzapine concentration which correlates it clinically. SUBJECTS AND METHODS: The work was agreed in 61 schizophrenic patients who were on olanzapine. Serum drug amount was estimated by normal-phase high-performance liquid chromatography and brief psychiatry rating scale was used to determine disease progression. RESULTS: Samples provided 61 patients, 40 were under sub-therapeutic range, 18 were under therapeutic range and 3 were above the therapeutic range. CONCLUSION: Therapeutic drug monitoring must be a part of clinical practice in psychiatric hospitals for optimizing the dose of an individual patient along with the correlation of serum concentration with the clinical assessment scales.

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