Therapeutic drug monitoring of olanzapine: Easy and reliable method for clinical correlation

AIM: The current work establishes an easy, reliable technique for the estimation of serum Olanzapine concentration which correlates it clinically. SUBJECTS AND METHODS: The work was agreed in 61 schizophrenic patients who were on olanzapine. Serum drug amount was estimated by normal-phase high-perfo...

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Autores principales: Junutula, Srinivas Pramod, Dubasi, Sai Kiran, Padide, Sai Geethika Reddy, Miryala, Gireesh Kumar, Koppolu, Manasa Soumya, Sheshagiri, Sharvana Bhava Bandaru, Eggadi, Venkateshwarlu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8216114/
https://www.ncbi.nlm.nih.gov/pubmed/33975992
http://dx.doi.org/10.4103/ijp.IJP_114_20
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author Junutula, Srinivas Pramod
Dubasi, Sai Kiran
Padide, Sai Geethika Reddy
Miryala, Gireesh Kumar
Koppolu, Manasa Soumya
Sheshagiri, Sharvana Bhava Bandaru
Eggadi, Venkateshwarlu
author_facet Junutula, Srinivas Pramod
Dubasi, Sai Kiran
Padide, Sai Geethika Reddy
Miryala, Gireesh Kumar
Koppolu, Manasa Soumya
Sheshagiri, Sharvana Bhava Bandaru
Eggadi, Venkateshwarlu
author_sort Junutula, Srinivas Pramod
collection PubMed
description AIM: The current work establishes an easy, reliable technique for the estimation of serum Olanzapine concentration which correlates it clinically. SUBJECTS AND METHODS: The work was agreed in 61 schizophrenic patients who were on olanzapine. Serum drug amount was estimated by normal-phase high-performance liquid chromatography and brief psychiatry rating scale was used to determine disease progression. RESULTS: Samples provided 61 patients, 40 were under sub-therapeutic range, 18 were under therapeutic range and 3 were above the therapeutic range. CONCLUSION: Therapeutic drug monitoring must be a part of clinical practice in psychiatric hospitals for optimizing the dose of an individual patient along with the correlation of serum concentration with the clinical assessment scales.
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spelling pubmed-82161142021-07-02 Therapeutic drug monitoring of olanzapine: Easy and reliable method for clinical correlation Junutula, Srinivas Pramod Dubasi, Sai Kiran Padide, Sai Geethika Reddy Miryala, Gireesh Kumar Koppolu, Manasa Soumya Sheshagiri, Sharvana Bhava Bandaru Eggadi, Venkateshwarlu Indian J Pharmacol Research Article AIM: The current work establishes an easy, reliable technique for the estimation of serum Olanzapine concentration which correlates it clinically. SUBJECTS AND METHODS: The work was agreed in 61 schizophrenic patients who were on olanzapine. Serum drug amount was estimated by normal-phase high-performance liquid chromatography and brief psychiatry rating scale was used to determine disease progression. RESULTS: Samples provided 61 patients, 40 were under sub-therapeutic range, 18 were under therapeutic range and 3 were above the therapeutic range. CONCLUSION: Therapeutic drug monitoring must be a part of clinical practice in psychiatric hospitals for optimizing the dose of an individual patient along with the correlation of serum concentration with the clinical assessment scales. Wolters Kluwer - Medknow 2021 2021-04-28 /pmc/articles/PMC8216114/ /pubmed/33975992 http://dx.doi.org/10.4103/ijp.IJP_114_20 Text en Copyright: © 2021 Indian Journal of Pharmacology https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Research Article
Junutula, Srinivas Pramod
Dubasi, Sai Kiran
Padide, Sai Geethika Reddy
Miryala, Gireesh Kumar
Koppolu, Manasa Soumya
Sheshagiri, Sharvana Bhava Bandaru
Eggadi, Venkateshwarlu
Therapeutic drug monitoring of olanzapine: Easy and reliable method for clinical correlation
title Therapeutic drug monitoring of olanzapine: Easy and reliable method for clinical correlation
title_full Therapeutic drug monitoring of olanzapine: Easy and reliable method for clinical correlation
title_fullStr Therapeutic drug monitoring of olanzapine: Easy and reliable method for clinical correlation
title_full_unstemmed Therapeutic drug monitoring of olanzapine: Easy and reliable method for clinical correlation
title_short Therapeutic drug monitoring of olanzapine: Easy and reliable method for clinical correlation
title_sort therapeutic drug monitoring of olanzapine: easy and reliable method for clinical correlation
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8216114/
https://www.ncbi.nlm.nih.gov/pubmed/33975992
http://dx.doi.org/10.4103/ijp.IJP_114_20
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