Risk of Environmental Exposure to H7N9 Influenza Virus via Airborne and Surface Routes in a Live Poultry Market in Hebei, China

Environmental transmission of viruses to humans has become an early warning for potential epidemic outbreaks, such as SARS-CoV-2 and influenza virus outbreaks. Recently, an H7N9 virus, A/environment/Hebei/621/2019 (H7N9), was isolated by environmental swabs from a live poultry market in Hebei, China...

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Autores principales: Zhang, Cheng, Guo, Kangkang, Cui, Huan, Chen, Ligong, Zhang, Chunmao, Wang, Xuejing, Li, Jiaming, Fu, Yingying, Wang, Zhongyi, Guo, Zhendong, Liu, Juxiang, Dong, Shishan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Cellular and Infection Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8216215/
https://www.ncbi.nlm.nih.gov/pubmed/34164347
http://dx.doi.org/10.3389/fcimb.2021.688007
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author Zhang, Cheng
Guo, Kangkang
Cui, Huan
Chen, Ligong
Zhang, Chunmao
Wang, Xuejing
Li, Jiaming
Fu, Yingying
Wang, Zhongyi
Guo, Zhendong
Liu, Juxiang
Dong, Shishan
author_facet Zhang, Cheng
Guo, Kangkang
Cui, Huan
Chen, Ligong
Zhang, Chunmao
Wang, Xuejing
Li, Jiaming
Fu, Yingying
Wang, Zhongyi
Guo, Zhendong
Liu, Juxiang
Dong, Shishan
author_sort Zhang, Cheng
collection PubMed
description Environmental transmission of viruses to humans has become an early warning for potential epidemic outbreaks, such as SARS-CoV-2 and influenza virus outbreaks. Recently, an H7N9 virus, A/environment/Hebei/621/2019 (H7N9), was isolated by environmental swabs from a live poultry market in Hebei, China. We found that this isolate could be transmitted by direct contact and aerosol in mammals. More importantly, after 5 passages in mice, the virus acquired two adaptive mutations, PB1-H115Q and B2-E627K, exhibiting increased virulence and aerosol transmissibility. These results suggest that this H7N9 virus might potentially be transmitted between humans through environmental or airborne routes.
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spelling pubmed-82162152021-06-22 Risk of Environmental Exposure to H7N9 Influenza Virus via Airborne and Surface Routes in a Live Poultry Market in Hebei, China Zhang, Cheng Guo, Kangkang Cui, Huan Chen, Ligong Zhang, Chunmao Wang, Xuejing Li, Jiaming Fu, Yingying Wang, Zhongyi Guo, Zhendong Liu, Juxiang Dong, Shishan Front Cell Infect Microbiol Cellular and Infection Microbiology Environmental transmission of viruses to humans has become an early warning for potential epidemic outbreaks, such as SARS-CoV-2 and influenza virus outbreaks. Recently, an H7N9 virus, A/environment/Hebei/621/2019 (H7N9), was isolated by environmental swabs from a live poultry market in Hebei, China. We found that this isolate could be transmitted by direct contact and aerosol in mammals. More importantly, after 5 passages in mice, the virus acquired two adaptive mutations, PB1-H115Q and B2-E627K, exhibiting increased virulence and aerosol transmissibility. These results suggest that this H7N9 virus might potentially be transmitted between humans through environmental or airborne routes. Frontiers Media S.A. 2021-06-07 /pmc/articles/PMC8216215/ /pubmed/34164347 http://dx.doi.org/10.3389/fcimb.2021.688007 Text en Copyright © 2021 Zhang, Guo, Cui, Chen, Zhang, Wang, Li, Fu, Wang, Guo, Liu and Dong https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cellular and Infection Microbiology
Zhang, Cheng
Guo, Kangkang
Cui, Huan
Chen, Ligong
Zhang, Chunmao
Wang, Xuejing
Li, Jiaming
Fu, Yingying
Wang, Zhongyi
Guo, Zhendong
Liu, Juxiang
Dong, Shishan
Risk of Environmental Exposure to H7N9 Influenza Virus via Airborne and Surface Routes in a Live Poultry Market in Hebei, China
title Risk of Environmental Exposure to H7N9 Influenza Virus via Airborne and Surface Routes in a Live Poultry Market in Hebei, China
title_full Risk of Environmental Exposure to H7N9 Influenza Virus via Airborne and Surface Routes in a Live Poultry Market in Hebei, China
title_fullStr Risk of Environmental Exposure to H7N9 Influenza Virus via Airborne and Surface Routes in a Live Poultry Market in Hebei, China
title_full_unstemmed Risk of Environmental Exposure to H7N9 Influenza Virus via Airborne and Surface Routes in a Live Poultry Market in Hebei, China
title_short Risk of Environmental Exposure to H7N9 Influenza Virus via Airborne and Surface Routes in a Live Poultry Market in Hebei, China
title_sort risk of environmental exposure to h7n9 influenza virus via airborne and surface routes in a live poultry market in hebei, china
topic Cellular and Infection Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8216215/
https://www.ncbi.nlm.nih.gov/pubmed/34164347
http://dx.doi.org/10.3389/fcimb.2021.688007
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