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Frequency and risk factors of non-alcoholic fatty liver disease in Helicobacter pylori-infected dyspeptic patients: A cross-sectional study

BACKGROUND: In dyspeptic patients with Helicobacter pylori contributes to non-alcoholic fatty liver disease. However, little evidence available from Pakistan. OBJECTIVE: The study aims to determine the frequency and risk factors of non-alcoholic fatty liver disease in dyspeptic patients with Helicob...

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Autores principales: Siddiqui, Basit, Kamran, Muhammad, Tikmani, Shiyam Sunder, Azmat, Rabeea, Mushtaq, Zain, Zafar, Saad Bin, Khan, Muhammad Tahir, Yakoob, Javed, Abbas, Zaigham
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8216349/
https://www.ncbi.nlm.nih.gov/pubmed/34211711
http://dx.doi.org/10.1177/20503121211025421
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author Siddiqui, Basit
Kamran, Muhammad
Tikmani, Shiyam Sunder
Azmat, Rabeea
Mushtaq, Zain
Zafar, Saad Bin
Khan, Muhammad Tahir
Yakoob, Javed
Abbas, Zaigham
author_facet Siddiqui, Basit
Kamran, Muhammad
Tikmani, Shiyam Sunder
Azmat, Rabeea
Mushtaq, Zain
Zafar, Saad Bin
Khan, Muhammad Tahir
Yakoob, Javed
Abbas, Zaigham
author_sort Siddiqui, Basit
collection PubMed
description BACKGROUND: In dyspeptic patients with Helicobacter pylori contributes to non-alcoholic fatty liver disease. However, little evidence available from Pakistan. OBJECTIVE: The study aims to determine the frequency and risk factors of non-alcoholic fatty liver disease in dyspeptic patients with Helicobacter pylori. METHODS: This cross-sectional study was conducted between 22 November 2016 and 30 June 2018. Adults of age between 18 and 90 years who attended the out-patient department due to abdominal discomfort, pain, fullness, and bloating who underwent upper gastrointestinal tract endoscopy were enrolled after taking informed consent. Patients with celiac disease, inflammatory bowel disease, taking alcohol, pregnant women and lactating mothers, known cases of hepatitis B and C, and history of recent antibiotic use were excluded. Data on age, gender, smoking, alcohol use, dyslipidemia, hypertension, type 2 diabetes mellitus, and ischemic heart disease were collected. Non-alcoholic fatty liver disease was diagnosed through ultrasonography. Helicobacter pylori infection was detected using a carbon urea breath test. RESULTS: A total of 698 patients were screened for eligibility, and 399 (57.2%) had Helicobacter pylori infection and were enrolled in the study after consent. The median age was 50.1 (interquartile range = 14.5) years and 209 (52.4%) were males. Frequency of non-alcoholic fatty liver disease in patients with Helicobacter pylori dyspeptic patients was 153 (38.3%). Factors associated with non-alcoholic fatty liver disease in the presence of Helicobacter pylori were dyslipidemia 7.38 (95% confidence interval = 2.4–22.71), type 2 diabetes mellitus 5.96 (95% confidence interval = 1.86–19.07), hypertension 3.0 (95% confidence interval = 1.21–7.45), and moderate gastritis 2.81 (95% confidence interval = 1.2–6.59). CONCLUSION: The frequency of non-alcoholic fatty liver disease in Helicobacter Pylori dyspeptic patients was 38.3%. Male gender, dyslipidemia, hypertension, ischemic heart disease, and moderate gastritis were associated with non-alcoholic fatty liver disease.
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spelling pubmed-82163492021-06-30 Frequency and risk factors of non-alcoholic fatty liver disease in Helicobacter pylori-infected dyspeptic patients: A cross-sectional study Siddiqui, Basit Kamran, Muhammad Tikmani, Shiyam Sunder Azmat, Rabeea Mushtaq, Zain Zafar, Saad Bin Khan, Muhammad Tahir Yakoob, Javed Abbas, Zaigham SAGE Open Med Original Research Article BACKGROUND: In dyspeptic patients with Helicobacter pylori contributes to non-alcoholic fatty liver disease. However, little evidence available from Pakistan. OBJECTIVE: The study aims to determine the frequency and risk factors of non-alcoholic fatty liver disease in dyspeptic patients with Helicobacter pylori. METHODS: This cross-sectional study was conducted between 22 November 2016 and 30 June 2018. Adults of age between 18 and 90 years who attended the out-patient department due to abdominal discomfort, pain, fullness, and bloating who underwent upper gastrointestinal tract endoscopy were enrolled after taking informed consent. Patients with celiac disease, inflammatory bowel disease, taking alcohol, pregnant women and lactating mothers, known cases of hepatitis B and C, and history of recent antibiotic use were excluded. Data on age, gender, smoking, alcohol use, dyslipidemia, hypertension, type 2 diabetes mellitus, and ischemic heart disease were collected. Non-alcoholic fatty liver disease was diagnosed through ultrasonography. Helicobacter pylori infection was detected using a carbon urea breath test. RESULTS: A total of 698 patients were screened for eligibility, and 399 (57.2%) had Helicobacter pylori infection and were enrolled in the study after consent. The median age was 50.1 (interquartile range = 14.5) years and 209 (52.4%) were males. Frequency of non-alcoholic fatty liver disease in patients with Helicobacter pylori dyspeptic patients was 153 (38.3%). Factors associated with non-alcoholic fatty liver disease in the presence of Helicobacter pylori were dyslipidemia 7.38 (95% confidence interval = 2.4–22.71), type 2 diabetes mellitus 5.96 (95% confidence interval = 1.86–19.07), hypertension 3.0 (95% confidence interval = 1.21–7.45), and moderate gastritis 2.81 (95% confidence interval = 1.2–6.59). CONCLUSION: The frequency of non-alcoholic fatty liver disease in Helicobacter Pylori dyspeptic patients was 38.3%. Male gender, dyslipidemia, hypertension, ischemic heart disease, and moderate gastritis were associated with non-alcoholic fatty liver disease. SAGE Publications 2021-06-18 /pmc/articles/PMC8216349/ /pubmed/34211711 http://dx.doi.org/10.1177/20503121211025421 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Original Research Article
Siddiqui, Basit
Kamran, Muhammad
Tikmani, Shiyam Sunder
Azmat, Rabeea
Mushtaq, Zain
Zafar, Saad Bin
Khan, Muhammad Tahir
Yakoob, Javed
Abbas, Zaigham
Frequency and risk factors of non-alcoholic fatty liver disease in Helicobacter pylori-infected dyspeptic patients: A cross-sectional study
title Frequency and risk factors of non-alcoholic fatty liver disease in Helicobacter pylori-infected dyspeptic patients: A cross-sectional study
title_full Frequency and risk factors of non-alcoholic fatty liver disease in Helicobacter pylori-infected dyspeptic patients: A cross-sectional study
title_fullStr Frequency and risk factors of non-alcoholic fatty liver disease in Helicobacter pylori-infected dyspeptic patients: A cross-sectional study
title_full_unstemmed Frequency and risk factors of non-alcoholic fatty liver disease in Helicobacter pylori-infected dyspeptic patients: A cross-sectional study
title_short Frequency and risk factors of non-alcoholic fatty liver disease in Helicobacter pylori-infected dyspeptic patients: A cross-sectional study
title_sort frequency and risk factors of non-alcoholic fatty liver disease in helicobacter pylori-infected dyspeptic patients: a cross-sectional study
topic Original Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8216349/
https://www.ncbi.nlm.nih.gov/pubmed/34211711
http://dx.doi.org/10.1177/20503121211025421
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