Cargando…
F7 and topotecan co-loaded thermosensitive liposome as a nano-drug delivery system for tumor hyperthermia
In order to enhance the targeting efficiency and reduce anti-tumor drug’s side effects, topotecan (TPT) and F7 were co-loaded in thermosensitive liposomes (F7-TPT-TSL), which show enhanced permeability and retention in tumors, as well as local controlled release by heating in vitro. TPT is a water-s...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8216433/ https://www.ncbi.nlm.nih.gov/pubmed/32508162 http://dx.doi.org/10.1080/10717544.2020.1772409 |
_version_ | 1783710417292361728 |
---|---|
author | Du, Chunyang Li, Shuangshuang Li, Yuan Galons, Hervé Guo, Na Teng, Yuou Zhang, Yongmin Li, Mingyuan Yu, Peng |
author_facet | Du, Chunyang Li, Shuangshuang Li, Yuan Galons, Hervé Guo, Na Teng, Yuou Zhang, Yongmin Li, Mingyuan Yu, Peng |
author_sort | Du, Chunyang |
collection | PubMed |
description | In order to enhance the targeting efficiency and reduce anti-tumor drug’s side effects, topotecan (TPT) and F7 were co-loaded in thermosensitive liposomes (F7-TPT-TSL), which show enhanced permeability and retention in tumors, as well as local controlled release by heating in vitro. TPT is a water-soluble inhibitor of topoisomerase I that is converted to an inactive carboxylate structure under physiological conditions (pH 7.4). F7 is a novel drug significantly resistant to cyclin-dependent kinase but its use was restricted by its high toxicity. F7-TPT-TSL had excellent particle distribution (about 103 nm), high entrapment efficiency (>95%), obvious thermosensitive property, and good stability. Confocal microscopy demonstrated specific higher accumulation of TSL in tumor cells. MTT proved F7-TPT-TSL/H had strongest cell lethality compared with other formulations. Then therapeutic efficacy revealed synergism of TPT and F7 co-loaded in TSL, together with hyperthermia. Therefore, the F7-TPT-TSL may serve as a promising system for temperature triggered cancer treatment. |
format | Online Article Text |
id | pubmed-8216433 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-82164332021-07-06 F7 and topotecan co-loaded thermosensitive liposome as a nano-drug delivery system for tumor hyperthermia Du, Chunyang Li, Shuangshuang Li, Yuan Galons, Hervé Guo, Na Teng, Yuou Zhang, Yongmin Li, Mingyuan Yu, Peng Drug Deliv Research Article In order to enhance the targeting efficiency and reduce anti-tumor drug’s side effects, topotecan (TPT) and F7 were co-loaded in thermosensitive liposomes (F7-TPT-TSL), which show enhanced permeability and retention in tumors, as well as local controlled release by heating in vitro. TPT is a water-soluble inhibitor of topoisomerase I that is converted to an inactive carboxylate structure under physiological conditions (pH 7.4). F7 is a novel drug significantly resistant to cyclin-dependent kinase but its use was restricted by its high toxicity. F7-TPT-TSL had excellent particle distribution (about 103 nm), high entrapment efficiency (>95%), obvious thermosensitive property, and good stability. Confocal microscopy demonstrated specific higher accumulation of TSL in tumor cells. MTT proved F7-TPT-TSL/H had strongest cell lethality compared with other formulations. Then therapeutic efficacy revealed synergism of TPT and F7 co-loaded in TSL, together with hyperthermia. Therefore, the F7-TPT-TSL may serve as a promising system for temperature triggered cancer treatment. Taylor & Francis 2020-06-08 /pmc/articles/PMC8216433/ /pubmed/32508162 http://dx.doi.org/10.1080/10717544.2020.1772409 Text en © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Du, Chunyang Li, Shuangshuang Li, Yuan Galons, Hervé Guo, Na Teng, Yuou Zhang, Yongmin Li, Mingyuan Yu, Peng F7 and topotecan co-loaded thermosensitive liposome as a nano-drug delivery system for tumor hyperthermia |
title | F7 and topotecan co-loaded thermosensitive liposome as a nano-drug delivery system for tumor hyperthermia |
title_full | F7 and topotecan co-loaded thermosensitive liposome as a nano-drug delivery system for tumor hyperthermia |
title_fullStr | F7 and topotecan co-loaded thermosensitive liposome as a nano-drug delivery system for tumor hyperthermia |
title_full_unstemmed | F7 and topotecan co-loaded thermosensitive liposome as a nano-drug delivery system for tumor hyperthermia |
title_short | F7 and topotecan co-loaded thermosensitive liposome as a nano-drug delivery system for tumor hyperthermia |
title_sort | f7 and topotecan co-loaded thermosensitive liposome as a nano-drug delivery system for tumor hyperthermia |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8216433/ https://www.ncbi.nlm.nih.gov/pubmed/32508162 http://dx.doi.org/10.1080/10717544.2020.1772409 |
work_keys_str_mv | AT duchunyang f7andtopotecancoloadedthermosensitiveliposomeasananodrugdeliverysystemfortumorhyperthermia AT lishuangshuang f7andtopotecancoloadedthermosensitiveliposomeasananodrugdeliverysystemfortumorhyperthermia AT liyuan f7andtopotecancoloadedthermosensitiveliposomeasananodrugdeliverysystemfortumorhyperthermia AT galonsherve f7andtopotecancoloadedthermosensitiveliposomeasananodrugdeliverysystemfortumorhyperthermia AT guona f7andtopotecancoloadedthermosensitiveliposomeasananodrugdeliverysystemfortumorhyperthermia AT tengyuou f7andtopotecancoloadedthermosensitiveliposomeasananodrugdeliverysystemfortumorhyperthermia AT zhangyongmin f7andtopotecancoloadedthermosensitiveliposomeasananodrugdeliverysystemfortumorhyperthermia AT limingyuan f7andtopotecancoloadedthermosensitiveliposomeasananodrugdeliverysystemfortumorhyperthermia AT yupeng f7andtopotecancoloadedthermosensitiveliposomeasananodrugdeliverysystemfortumorhyperthermia |