The H3K36me2 methyltransferase NSD1 modulates H3K27ac at active enhancers to safeguard gene expression

Epigenetics, especially histone marks, functions beyond the DNA sequences to regulate gene expression. Depletion of NSD1, which catalyzes H3K36me2, leads to both up- and down-regulation of gene expression, indicating NSD1 is associated with both active and repressed gene expression. It's known...

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Detalles Bibliográficos
Autores principales: Fang, Yuan, Tang, Yin, Zhang, Yanjun, Pan, Yixin, Jia, Junqi, Sun, Zhongxing, Zeng, Weiwu, Chen, Jiaqi, Yuan, Ying, Fang, Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8216457/
https://www.ncbi.nlm.nih.gov/pubmed/34107030
http://dx.doi.org/10.1093/nar/gkab473

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