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The synthetic synergistic cinnamon oil CIN-102 is active against Madurella mycetomatis, the most common causative agent of mycetoma

Mycetoma is a devastating neglected tropical infection of the subcutaneous tissue and most commonly caused by the fungus Madurella mycetomatis. Treatment of mycetoma consists of a combination of a long term antifungal treatment with itraconazole and surgery. However, treatment is associated with low...

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Autores principales: Konings, Mickey, Eadie, Kimberly, Lim, Wilson, Fahal, Ahmed H., Mouton, Johan, Tesse, Nicolas, van de Sande, Wendy W. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8216527/
https://www.ncbi.nlm.nih.gov/pubmed/34106933
http://dx.doi.org/10.1371/journal.pntd.0009488
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author Konings, Mickey
Eadie, Kimberly
Lim, Wilson
Fahal, Ahmed H.
Mouton, Johan
Tesse, Nicolas
van de Sande, Wendy W. J.
author_facet Konings, Mickey
Eadie, Kimberly
Lim, Wilson
Fahal, Ahmed H.
Mouton, Johan
Tesse, Nicolas
van de Sande, Wendy W. J.
author_sort Konings, Mickey
collection PubMed
description Mycetoma is a devastating neglected tropical infection of the subcutaneous tissue and most commonly caused by the fungus Madurella mycetomatis. Treatment of mycetoma consists of a combination of a long term antifungal treatment with itraconazole and surgery. However, treatment is associated with low success rates. Therefore, there is a need to identify novel treatments for mycetoma. CIN-102 is a synthetic partial copy of cinnamon oils with activity against many pathogenic bacteria and fungi. In this study we determined the in vitro activity of CIN-102 against 21 M. mycetomatis isolates and its in vivo efficacy in a M. mycetomatis infected Galleria mellonella larval model. In vitro, CIN-102 was active against M. mycetomatis with MICs ranging from 32 μg/mL to 512 μg/mL. 128 μg/mL was needed to inhibit the growth in 50% of tested isolates. In vivo, concentrations below the MIC of 40 mg/kg and 80 mg/kg CIN-102 prolonged larval survival, but higher concentrations of CIN-102 did not.
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spelling pubmed-82165272021-07-01 The synthetic synergistic cinnamon oil CIN-102 is active against Madurella mycetomatis, the most common causative agent of mycetoma Konings, Mickey Eadie, Kimberly Lim, Wilson Fahal, Ahmed H. Mouton, Johan Tesse, Nicolas van de Sande, Wendy W. J. PLoS Negl Trop Dis Research Article Mycetoma is a devastating neglected tropical infection of the subcutaneous tissue and most commonly caused by the fungus Madurella mycetomatis. Treatment of mycetoma consists of a combination of a long term antifungal treatment with itraconazole and surgery. However, treatment is associated with low success rates. Therefore, there is a need to identify novel treatments for mycetoma. CIN-102 is a synthetic partial copy of cinnamon oils with activity against many pathogenic bacteria and fungi. In this study we determined the in vitro activity of CIN-102 against 21 M. mycetomatis isolates and its in vivo efficacy in a M. mycetomatis infected Galleria mellonella larval model. In vitro, CIN-102 was active against M. mycetomatis with MICs ranging from 32 μg/mL to 512 μg/mL. 128 μg/mL was needed to inhibit the growth in 50% of tested isolates. In vivo, concentrations below the MIC of 40 mg/kg and 80 mg/kg CIN-102 prolonged larval survival, but higher concentrations of CIN-102 did not. Public Library of Science 2021-06-09 /pmc/articles/PMC8216527/ /pubmed/34106933 http://dx.doi.org/10.1371/journal.pntd.0009488 Text en © 2021 Konings et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Konings, Mickey
Eadie, Kimberly
Lim, Wilson
Fahal, Ahmed H.
Mouton, Johan
Tesse, Nicolas
van de Sande, Wendy W. J.
The synthetic synergistic cinnamon oil CIN-102 is active against Madurella mycetomatis, the most common causative agent of mycetoma
title The synthetic synergistic cinnamon oil CIN-102 is active against Madurella mycetomatis, the most common causative agent of mycetoma
title_full The synthetic synergistic cinnamon oil CIN-102 is active against Madurella mycetomatis, the most common causative agent of mycetoma
title_fullStr The synthetic synergistic cinnamon oil CIN-102 is active against Madurella mycetomatis, the most common causative agent of mycetoma
title_full_unstemmed The synthetic synergistic cinnamon oil CIN-102 is active against Madurella mycetomatis, the most common causative agent of mycetoma
title_short The synthetic synergistic cinnamon oil CIN-102 is active against Madurella mycetomatis, the most common causative agent of mycetoma
title_sort synthetic synergistic cinnamon oil cin-102 is active against madurella mycetomatis, the most common causative agent of mycetoma
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8216527/
https://www.ncbi.nlm.nih.gov/pubmed/34106933
http://dx.doi.org/10.1371/journal.pntd.0009488
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