Optimal protamine dosing after cardiopulmonary bypass: The PRODOSE adaptive randomised controlled trial

BACKGROUND: The dose of protamine required following cardiopulmonary bypass (CPB) is often determined by the dose of heparin required pre-CPB, expressed as a fixed ratio. Dosing based on mathematical models of heparin clearance is postulated to improve protamine dosing precision and coagulation. We...

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Detalles Bibliográficos
Autores principales: Miles, Lachlan F., Burt, Christiana, Arrowsmith, Joseph, McKie, Mikel A., Villar, Sofia S., Govender, Pooveshnie, Shaylor, Ruth, Tan, Zihui, De Silva, Ravi, Falter, Florian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8216535/
https://www.ncbi.nlm.nih.gov/pubmed/34097705
http://dx.doi.org/10.1371/journal.pmed.1003658

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