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Blood coagulation parameter abnormalities in hospitalized patients with confirmed COVID-19 in Ethiopia

BACKGROUND: Coagulopathy and thromboembolic events are among the complications of Corona Virus disease 2019 (COVID-19). Abnormal coagulation parameters in COVID-19 patients are important prognostic factors of disease severity. The aim of this study was to analyze coagulation profiles of hospitalized...

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Autores principales: Araya, Shambel, Mamo, Mintesnot Aragaw, Tsegay, Yakob Gebregziabher, Atlaw, Asegdew, Aytenew, Aschalew, Hordofa, Abebe, Negeso, Abebe Edao, Wordofa, Moges, Niguse, Tirhas, Cheru, Mahlet, Tamir, Zemenu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8216564/
https://www.ncbi.nlm.nih.gov/pubmed/34153056
http://dx.doi.org/10.1371/journal.pone.0252939
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author Araya, Shambel
Mamo, Mintesnot Aragaw
Tsegay, Yakob Gebregziabher
Atlaw, Asegdew
Aytenew, Aschalew
Hordofa, Abebe
Negeso, Abebe Edao
Wordofa, Moges
Niguse, Tirhas
Cheru, Mahlet
Tamir, Zemenu
author_facet Araya, Shambel
Mamo, Mintesnot Aragaw
Tsegay, Yakob Gebregziabher
Atlaw, Asegdew
Aytenew, Aschalew
Hordofa, Abebe
Negeso, Abebe Edao
Wordofa, Moges
Niguse, Tirhas
Cheru, Mahlet
Tamir, Zemenu
author_sort Araya, Shambel
collection PubMed
description BACKGROUND: Coagulopathy and thromboembolic events are among the complications of Corona Virus disease 2019 (COVID-19). Abnormal coagulation parameters in COVID-19 patients are important prognostic factors of disease severity. The aim of this study was to analyze coagulation profiles of hospitalized COVID-19 patients in Addis Ababa, Ethiopia. METHODS: This prospective cross-sectional study was conducted among 455 Covid-19 patients admitted at Millennium COVID-19 care and treatment center, Addis Ababa, Ethiopia from July 1- October 23, 2020. Prothrombin Time (PT), Activated Partial Thromboplastin Time (APTT) and International normalized ratio (INR) were determined on HUMACLOT DUE PLUS® coagulation analyzer (Wiesbaden, Germany). In all statistical analysis of results, p<0.05 was defined as statistically significant. RESULT: A prolonged prothrombin time was found in 46.8% of study participants with COVID-19 and a prolonged prothrombin time and elevated INR in 53.3% of study subjects with severe and 51% of critically COVID patients. Thrombocytopenia was detected in 22.1% of COVID-19 patients. 50.5% and 51.3% of COVID-19 patients older than 55 years had thrombocytopenia and prolonged APTT respectively. CONCLUSION: In this study, prolonged prothrombin time and elevated INR were detected in more than 50% of severe and critical COVID-19 patients. Thrombocytopenia and prolonged APTT were dominant in COVID-19 patients older than 55 years. Thus, we recommend emphasis to be given for monitoring of platelet count, PT, APTT and INR in hospitalized and admitted COVID-19 patients.
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spelling pubmed-82165642021-07-01 Blood coagulation parameter abnormalities in hospitalized patients with confirmed COVID-19 in Ethiopia Araya, Shambel Mamo, Mintesnot Aragaw Tsegay, Yakob Gebregziabher Atlaw, Asegdew Aytenew, Aschalew Hordofa, Abebe Negeso, Abebe Edao Wordofa, Moges Niguse, Tirhas Cheru, Mahlet Tamir, Zemenu PLoS One Research Article BACKGROUND: Coagulopathy and thromboembolic events are among the complications of Corona Virus disease 2019 (COVID-19). Abnormal coagulation parameters in COVID-19 patients are important prognostic factors of disease severity. The aim of this study was to analyze coagulation profiles of hospitalized COVID-19 patients in Addis Ababa, Ethiopia. METHODS: This prospective cross-sectional study was conducted among 455 Covid-19 patients admitted at Millennium COVID-19 care and treatment center, Addis Ababa, Ethiopia from July 1- October 23, 2020. Prothrombin Time (PT), Activated Partial Thromboplastin Time (APTT) and International normalized ratio (INR) were determined on HUMACLOT DUE PLUS® coagulation analyzer (Wiesbaden, Germany). In all statistical analysis of results, p<0.05 was defined as statistically significant. RESULT: A prolonged prothrombin time was found in 46.8% of study participants with COVID-19 and a prolonged prothrombin time and elevated INR in 53.3% of study subjects with severe and 51% of critically COVID patients. Thrombocytopenia was detected in 22.1% of COVID-19 patients. 50.5% and 51.3% of COVID-19 patients older than 55 years had thrombocytopenia and prolonged APTT respectively. CONCLUSION: In this study, prolonged prothrombin time and elevated INR were detected in more than 50% of severe and critical COVID-19 patients. Thrombocytopenia and prolonged APTT were dominant in COVID-19 patients older than 55 years. Thus, we recommend emphasis to be given for monitoring of platelet count, PT, APTT and INR in hospitalized and admitted COVID-19 patients. Public Library of Science 2021-06-21 /pmc/articles/PMC8216564/ /pubmed/34153056 http://dx.doi.org/10.1371/journal.pone.0252939 Text en © 2021 Araya et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Araya, Shambel
Mamo, Mintesnot Aragaw
Tsegay, Yakob Gebregziabher
Atlaw, Asegdew
Aytenew, Aschalew
Hordofa, Abebe
Negeso, Abebe Edao
Wordofa, Moges
Niguse, Tirhas
Cheru, Mahlet
Tamir, Zemenu
Blood coagulation parameter abnormalities in hospitalized patients with confirmed COVID-19 in Ethiopia
title Blood coagulation parameter abnormalities in hospitalized patients with confirmed COVID-19 in Ethiopia
title_full Blood coagulation parameter abnormalities in hospitalized patients with confirmed COVID-19 in Ethiopia
title_fullStr Blood coagulation parameter abnormalities in hospitalized patients with confirmed COVID-19 in Ethiopia
title_full_unstemmed Blood coagulation parameter abnormalities in hospitalized patients with confirmed COVID-19 in Ethiopia
title_short Blood coagulation parameter abnormalities in hospitalized patients with confirmed COVID-19 in Ethiopia
title_sort blood coagulation parameter abnormalities in hospitalized patients with confirmed covid-19 in ethiopia
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8216564/
https://www.ncbi.nlm.nih.gov/pubmed/34153056
http://dx.doi.org/10.1371/journal.pone.0252939
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