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The New Kid on the Block: The Mechanisms of Action of Hyperleptinemia in Coronary Artery Disease and Atherosclerosis
Leptin is an adipocytokine that consists of 167 amino acids. It functions as a regulator of hunger and energy expenditure. Leptin loses its ability to carry out its physiological function at high serum levels, and many studies have associated this loss of function with the development of coronary ar...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cureus
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8216571/ https://www.ncbi.nlm.nih.gov/pubmed/34178553 http://dx.doi.org/10.7759/cureus.15766 |
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author | Hernandez, Vernicia Kaur, Kavaljeet ElSharief, Mohamed W Al Hajaj, Sari W Ebrahim, Ahmed M Razack, Mirash Dragas, David |
author_facet | Hernandez, Vernicia Kaur, Kavaljeet ElSharief, Mohamed W Al Hajaj, Sari W Ebrahim, Ahmed M Razack, Mirash Dragas, David |
author_sort | Hernandez, Vernicia |
collection | PubMed |
description | Leptin is an adipocytokine that consists of 167 amino acids. It functions as a regulator of hunger and energy expenditure. Leptin loses its ability to carry out its physiological function at high serum levels, and many studies have associated this loss of function with the development of coronary artery disease (CAD). This literature review aims to outline the steps by which leptin leads to CAD and atherosclerosis. Two independent researchers extracted animal and human studies from PubMed and Google Scholar databases. We applied PubMed search builder options: pathology, pathophysiology, metabolism, and physiology to focus the search results. This study concluded that the mechanism by which leptin might lead to CAD via pressor and depressor effects on vascular tone, enhancing atherosclerotic plaques, and through numerous single nucleotide polymorphisms, the most common being that of the leptin receptor gene rs113701. |
format | Online Article Text |
id | pubmed-8216571 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Cureus |
record_format | MEDLINE/PubMed |
spelling | pubmed-82165712021-06-24 The New Kid on the Block: The Mechanisms of Action of Hyperleptinemia in Coronary Artery Disease and Atherosclerosis Hernandez, Vernicia Kaur, Kavaljeet ElSharief, Mohamed W Al Hajaj, Sari W Ebrahim, Ahmed M Razack, Mirash Dragas, David Cureus Cardiology Leptin is an adipocytokine that consists of 167 amino acids. It functions as a regulator of hunger and energy expenditure. Leptin loses its ability to carry out its physiological function at high serum levels, and many studies have associated this loss of function with the development of coronary artery disease (CAD). This literature review aims to outline the steps by which leptin leads to CAD and atherosclerosis. Two independent researchers extracted animal and human studies from PubMed and Google Scholar databases. We applied PubMed search builder options: pathology, pathophysiology, metabolism, and physiology to focus the search results. This study concluded that the mechanism by which leptin might lead to CAD via pressor and depressor effects on vascular tone, enhancing atherosclerotic plaques, and through numerous single nucleotide polymorphisms, the most common being that of the leptin receptor gene rs113701. Cureus 2021-06-20 /pmc/articles/PMC8216571/ /pubmed/34178553 http://dx.doi.org/10.7759/cureus.15766 Text en Copyright © 2021, Hernandez et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Cardiology Hernandez, Vernicia Kaur, Kavaljeet ElSharief, Mohamed W Al Hajaj, Sari W Ebrahim, Ahmed M Razack, Mirash Dragas, David The New Kid on the Block: The Mechanisms of Action of Hyperleptinemia in Coronary Artery Disease and Atherosclerosis |
title | The New Kid on the Block: The Mechanisms of Action of Hyperleptinemia in Coronary Artery Disease and Atherosclerosis |
title_full | The New Kid on the Block: The Mechanisms of Action of Hyperleptinemia in Coronary Artery Disease and Atherosclerosis |
title_fullStr | The New Kid on the Block: The Mechanisms of Action of Hyperleptinemia in Coronary Artery Disease and Atherosclerosis |
title_full_unstemmed | The New Kid on the Block: The Mechanisms of Action of Hyperleptinemia in Coronary Artery Disease and Atherosclerosis |
title_short | The New Kid on the Block: The Mechanisms of Action of Hyperleptinemia in Coronary Artery Disease and Atherosclerosis |
title_sort | new kid on the block: the mechanisms of action of hyperleptinemia in coronary artery disease and atherosclerosis |
topic | Cardiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8216571/ https://www.ncbi.nlm.nih.gov/pubmed/34178553 http://dx.doi.org/10.7759/cureus.15766 |
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