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Associations Between Macronutrients From Different Dietary Sources and Serum Lipids in 24 639 UK Biobank Study Participants

OBJECTIVE: Macronutrients may relate differently with serum lipids depending on their source, and understanding this relationship is important for cardiovascular disease prevention. We aimed to investigate the associations between macronutrients and macronutrients from different sources with serum l...

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Autores principales: Kelly, Rebecca K., Watling, Cody Z., Tong, Tammy Y.N., Piernas, Carmen, Carter, Jennifer L., Papier, Keren, Key, Timothy J., Perez-Cornago, Aurora
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8216602/
https://www.ncbi.nlm.nih.gov/pubmed/34039019
http://dx.doi.org/10.1161/ATVBAHA.120.315628
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author Kelly, Rebecca K.
Watling, Cody Z.
Tong, Tammy Y.N.
Piernas, Carmen
Carter, Jennifer L.
Papier, Keren
Key, Timothy J.
Perez-Cornago, Aurora
author_facet Kelly, Rebecca K.
Watling, Cody Z.
Tong, Tammy Y.N.
Piernas, Carmen
Carter, Jennifer L.
Papier, Keren
Key, Timothy J.
Perez-Cornago, Aurora
author_sort Kelly, Rebecca K.
collection PubMed
description OBJECTIVE: Macronutrients may relate differently with serum lipids depending on their source, and understanding this relationship is important for cardiovascular disease prevention. We aimed to investigate the associations between macronutrients and macronutrients from different sources with serum lipids in UK Biobank. APPROACH AND RESULTS: Serum lipids were obtained from serum collected at baseline in 24 639 participants with diet assessed using ≥2 twenty-four–hour dietary assessments completed at baseline and during follow-up. Multivariable linear regressions were conducted to calculate geometric mean concentrations of serum lipids by quintiles of macronutrients. We modeled the association between isoenergetic substitution of 5% energy intake from saturated fatty acids (SFA) with other macronutrients and serum lipids. Free sugar intake was positively associated with triglycerides (0.15 mmol/L geometric mean difference between highest and lowest quintile of intake [95% CI, 0.12–0.17 mmol/L]), whereas nonfree sugar intake was inversely associated with triglycerides (−0.08 [−0.10 to −0.05]). SFA intake was positively associated with LDL-C (low-density lipoprotein cholesterol; 0.17 [0.13–0.20]), omega-3 fatty acid intake was inversely associated with triglycerides (−0.15 [−0.17 to −0.12]). Modeled substitution of SFA with polyunsaturated fatty acids was associated with lower total cholesterol, LDL-C, and triglycerides. CONCLUSIONS: The relationship between carbohydrates and triglycerides may depend on their quality, and reducing free sugar intake may be important in cardiovascular disease prevention. Consistent with previous studies, SFA intake is associated with LDL-C and substitution of SFA intake with polyunsaturated fatty acids intake may be associated with a more favorable serum lipid profile.
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spelling pubmed-82166022021-06-24 Associations Between Macronutrients From Different Dietary Sources and Serum Lipids in 24 639 UK Biobank Study Participants Kelly, Rebecca K. Watling, Cody Z. Tong, Tammy Y.N. Piernas, Carmen Carter, Jennifer L. Papier, Keren Key, Timothy J. Perez-Cornago, Aurora Arterioscler Thromb Vasc Biol Clinical and Population Studies OBJECTIVE: Macronutrients may relate differently with serum lipids depending on their source, and understanding this relationship is important for cardiovascular disease prevention. We aimed to investigate the associations between macronutrients and macronutrients from different sources with serum lipids in UK Biobank. APPROACH AND RESULTS: Serum lipids were obtained from serum collected at baseline in 24 639 participants with diet assessed using ≥2 twenty-four–hour dietary assessments completed at baseline and during follow-up. Multivariable linear regressions were conducted to calculate geometric mean concentrations of serum lipids by quintiles of macronutrients. We modeled the association between isoenergetic substitution of 5% energy intake from saturated fatty acids (SFA) with other macronutrients and serum lipids. Free sugar intake was positively associated with triglycerides (0.15 mmol/L geometric mean difference between highest and lowest quintile of intake [95% CI, 0.12–0.17 mmol/L]), whereas nonfree sugar intake was inversely associated with triglycerides (−0.08 [−0.10 to −0.05]). SFA intake was positively associated with LDL-C (low-density lipoprotein cholesterol; 0.17 [0.13–0.20]), omega-3 fatty acid intake was inversely associated with triglycerides (−0.15 [−0.17 to −0.12]). Modeled substitution of SFA with polyunsaturated fatty acids was associated with lower total cholesterol, LDL-C, and triglycerides. CONCLUSIONS: The relationship between carbohydrates and triglycerides may depend on their quality, and reducing free sugar intake may be important in cardiovascular disease prevention. Consistent with previous studies, SFA intake is associated with LDL-C and substitution of SFA intake with polyunsaturated fatty acids intake may be associated with a more favorable serum lipid profile. Lippincott Williams & Wilkins 2021-05-27 2021-07 /pmc/articles/PMC8216602/ /pubmed/34039019 http://dx.doi.org/10.1161/ATVBAHA.120.315628 Text en © 2021 The Authors. https://creativecommons.org/licenses/by/4.0/Arteriosclerosis, Thrombosis, and Vascular Biology is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited.
spellingShingle Clinical and Population Studies
Kelly, Rebecca K.
Watling, Cody Z.
Tong, Tammy Y.N.
Piernas, Carmen
Carter, Jennifer L.
Papier, Keren
Key, Timothy J.
Perez-Cornago, Aurora
Associations Between Macronutrients From Different Dietary Sources and Serum Lipids in 24 639 UK Biobank Study Participants
title Associations Between Macronutrients From Different Dietary Sources and Serum Lipids in 24 639 UK Biobank Study Participants
title_full Associations Between Macronutrients From Different Dietary Sources and Serum Lipids in 24 639 UK Biobank Study Participants
title_fullStr Associations Between Macronutrients From Different Dietary Sources and Serum Lipids in 24 639 UK Biobank Study Participants
title_full_unstemmed Associations Between Macronutrients From Different Dietary Sources and Serum Lipids in 24 639 UK Biobank Study Participants
title_short Associations Between Macronutrients From Different Dietary Sources and Serum Lipids in 24 639 UK Biobank Study Participants
title_sort associations between macronutrients from different dietary sources and serum lipids in 24 639 uk biobank study participants
topic Clinical and Population Studies
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8216602/
https://www.ncbi.nlm.nih.gov/pubmed/34039019
http://dx.doi.org/10.1161/ATVBAHA.120.315628
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