Cargando…
Relationship between the Severity of Coronary Artery Disease and Cardiovascular Risk Factors in Acute Coronary Syndrome: Based on Tehran Heart Center’s Data Registry
Background: Acute coronary syndrome (ACS) is one of the main causes of mortality worldwide. We sought to evaluate the correlation between the severity of coronary artery disease (CAD) and conventional coronary artery risk factors in a large cohort of patients with ACS. Methods: This study included a...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Tehran University of Medical Sciences
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8217186/ https://www.ncbi.nlm.nih.gov/pubmed/34178085 http://dx.doi.org/10.18502/jthc.v15i4.5942 |
_version_ | 1783710560726024192 |
---|---|
author | Omidi, Negar Sadeghian, Saeed Salarifar, Mojtaba Jalali, Arash Abbasi, Seyed Hesameddin Yavari, Negin Ghorashi, Seyyed Mojtaba Alidoosti, Mohammad Poorhosseini, Hamidreza |
author_facet | Omidi, Negar Sadeghian, Saeed Salarifar, Mojtaba Jalali, Arash Abbasi, Seyed Hesameddin Yavari, Negin Ghorashi, Seyyed Mojtaba Alidoosti, Mohammad Poorhosseini, Hamidreza |
author_sort | Omidi, Negar |
collection | PubMed |
description | Background: Acute coronary syndrome (ACS) is one of the main causes of mortality worldwide. We sought to evaluate the correlation between the severity of coronary artery disease (CAD) and conventional coronary artery risk factors in a large cohort of patients with ACS. Methods: This study included all patients admitted to the coronary care unit with a diagnosis of ACS between 2003 and 2017. The patients were divided into 2 groups: 1) unstable angina and 2) myocardial infarction. The aims of this study were to evaluate the effects of the risk factors and extension of coronary artery stenosis in patients with ACS according to the Gensini score. Results: Of a total 40 319 patients who presented with ACS, 18 862 patients (mean age =60.4±11.14 y, male: 67.2%) underwent conventional coronary angiography and met our criteria to enter the final analysis. The median of the Gensini score was 50 (25–88) in the study population. The multivariable analysis showed that age, sex, diabetes mellitus, hypertension, dyslipidemia, family history, cigarette smoking, opium consumption, and myocardial infarction increased the risk of positive Gensini scores. All the aforementioned risk factors, except cigarette smoking and opium consumption, increased the severity of stenosis in those with positive Gensini scores. The strongest relationship was seen vis-à-vis myocardial infarction, sex, and diabetes mellitus. Conclusion: Our findings suggest that age, sex, diabetes mellitus, dyslipidemia, hypertension, family history, and myocardial infarction have significant effects on the severity of CAD. The obesity paradox in relation to CAD should be taken into consideration and needs further investigation in patients with ACS. |
format | Online Article Text |
id | pubmed-8217186 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Tehran University of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-82171862021-06-25 Relationship between the Severity of Coronary Artery Disease and Cardiovascular Risk Factors in Acute Coronary Syndrome: Based on Tehran Heart Center’s Data Registry Omidi, Negar Sadeghian, Saeed Salarifar, Mojtaba Jalali, Arash Abbasi, Seyed Hesameddin Yavari, Negin Ghorashi, Seyyed Mojtaba Alidoosti, Mohammad Poorhosseini, Hamidreza J Tehran Heart Cent Original Article Background: Acute coronary syndrome (ACS) is one of the main causes of mortality worldwide. We sought to evaluate the correlation between the severity of coronary artery disease (CAD) and conventional coronary artery risk factors in a large cohort of patients with ACS. Methods: This study included all patients admitted to the coronary care unit with a diagnosis of ACS between 2003 and 2017. The patients were divided into 2 groups: 1) unstable angina and 2) myocardial infarction. The aims of this study were to evaluate the effects of the risk factors and extension of coronary artery stenosis in patients with ACS according to the Gensini score. Results: Of a total 40 319 patients who presented with ACS, 18 862 patients (mean age =60.4±11.14 y, male: 67.2%) underwent conventional coronary angiography and met our criteria to enter the final analysis. The median of the Gensini score was 50 (25–88) in the study population. The multivariable analysis showed that age, sex, diabetes mellitus, hypertension, dyslipidemia, family history, cigarette smoking, opium consumption, and myocardial infarction increased the risk of positive Gensini scores. All the aforementioned risk factors, except cigarette smoking and opium consumption, increased the severity of stenosis in those with positive Gensini scores. The strongest relationship was seen vis-à-vis myocardial infarction, sex, and diabetes mellitus. Conclusion: Our findings suggest that age, sex, diabetes mellitus, dyslipidemia, hypertension, family history, and myocardial infarction have significant effects on the severity of CAD. The obesity paradox in relation to CAD should be taken into consideration and needs further investigation in patients with ACS. Tehran University of Medical Sciences 2020-10 /pmc/articles/PMC8217186/ /pubmed/34178085 http://dx.doi.org/10.18502/jthc.v15i4.5942 Text en Copyright © 2020 Tehran University of Medical Sciences. https://creativecommons.org/licenses/by-nc/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International license (https://creativecommons.org/licenses/by-nc/4.0/). Non-commercial uses of the work are permitted, provided the original work is properly cited. |
spellingShingle | Original Article Omidi, Negar Sadeghian, Saeed Salarifar, Mojtaba Jalali, Arash Abbasi, Seyed Hesameddin Yavari, Negin Ghorashi, Seyyed Mojtaba Alidoosti, Mohammad Poorhosseini, Hamidreza Relationship between the Severity of Coronary Artery Disease and Cardiovascular Risk Factors in Acute Coronary Syndrome: Based on Tehran Heart Center’s Data Registry |
title | Relationship between the Severity of Coronary Artery Disease and Cardiovascular Risk Factors in Acute Coronary Syndrome: Based on Tehran Heart Center’s Data Registry |
title_full | Relationship between the Severity of Coronary Artery Disease and Cardiovascular Risk Factors in Acute Coronary Syndrome: Based on Tehran Heart Center’s Data Registry |
title_fullStr | Relationship between the Severity of Coronary Artery Disease and Cardiovascular Risk Factors in Acute Coronary Syndrome: Based on Tehran Heart Center’s Data Registry |
title_full_unstemmed | Relationship between the Severity of Coronary Artery Disease and Cardiovascular Risk Factors in Acute Coronary Syndrome: Based on Tehran Heart Center’s Data Registry |
title_short | Relationship between the Severity of Coronary Artery Disease and Cardiovascular Risk Factors in Acute Coronary Syndrome: Based on Tehran Heart Center’s Data Registry |
title_sort | relationship between the severity of coronary artery disease and cardiovascular risk factors in acute coronary syndrome: based on tehran heart center’s data registry |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8217186/ https://www.ncbi.nlm.nih.gov/pubmed/34178085 http://dx.doi.org/10.18502/jthc.v15i4.5942 |
work_keys_str_mv | AT omidinegar relationshipbetweentheseverityofcoronaryarterydiseaseandcardiovascularriskfactorsinacutecoronarysyndromebasedontehranheartcentersdataregistry AT sadeghiansaeed relationshipbetweentheseverityofcoronaryarterydiseaseandcardiovascularriskfactorsinacutecoronarysyndromebasedontehranheartcentersdataregistry AT salarifarmojtaba relationshipbetweentheseverityofcoronaryarterydiseaseandcardiovascularriskfactorsinacutecoronarysyndromebasedontehranheartcentersdataregistry AT jalaliarash relationshipbetweentheseverityofcoronaryarterydiseaseandcardiovascularriskfactorsinacutecoronarysyndromebasedontehranheartcentersdataregistry AT abbasiseyedhesameddin relationshipbetweentheseverityofcoronaryarterydiseaseandcardiovascularriskfactorsinacutecoronarysyndromebasedontehranheartcentersdataregistry AT yavarinegin relationshipbetweentheseverityofcoronaryarterydiseaseandcardiovascularriskfactorsinacutecoronarysyndromebasedontehranheartcentersdataregistry AT ghorashiseyyedmojtaba relationshipbetweentheseverityofcoronaryarterydiseaseandcardiovascularriskfactorsinacutecoronarysyndromebasedontehranheartcentersdataregistry AT alidoostimohammad relationshipbetweentheseverityofcoronaryarterydiseaseandcardiovascularriskfactorsinacutecoronarysyndromebasedontehranheartcentersdataregistry AT poorhosseinihamidreza relationshipbetweentheseverityofcoronaryarterydiseaseandcardiovascularriskfactorsinacutecoronarysyndromebasedontehranheartcentersdataregistry |