Cargando…
Inhibition of the IFN Response by Bluetongue Virus: The Story So Far
Bluetongue virus (BTV) is the prototypical orbivirus that belongs to the Reoviridae family. BTV infection produces a disease in ruminants, particularly in sheep, that results in economic losses through reduced productivity. BTV is transmitted by the bite of Culicoides spp. midges and is nowadays dis...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8217435/ https://www.ncbi.nlm.nih.gov/pubmed/34168637 http://dx.doi.org/10.3389/fmicb.2021.692069 |
_version_ | 1783710587992145920 |
---|---|
author | Rojas, José Manuel Avia, Miguel Martín, Verónica Sevilla, Noemí |
author_facet | Rojas, José Manuel Avia, Miguel Martín, Verónica Sevilla, Noemí |
author_sort | Rojas, José Manuel |
collection | PubMed |
description | Bluetongue virus (BTV) is the prototypical orbivirus that belongs to the Reoviridae family. BTV infection produces a disease in ruminants, particularly in sheep, that results in economic losses through reduced productivity. BTV is transmitted by the bite of Culicoides spp. midges and is nowadays distributed globally throughout subtropical and even temperate regions. As most viruses, BTV is susceptible to the IFN response, the first line of defense employed by the immune system to combat viral infections. In turn, BTV has evolved strategies to counter the IFN response and promote its replication. The present review we will revise the works describing how BTV interferes with the IFN response. |
format | Online Article Text |
id | pubmed-8217435 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-82174352021-06-23 Inhibition of the IFN Response by Bluetongue Virus: The Story So Far Rojas, José Manuel Avia, Miguel Martín, Verónica Sevilla, Noemí Front Microbiol Microbiology Bluetongue virus (BTV) is the prototypical orbivirus that belongs to the Reoviridae family. BTV infection produces a disease in ruminants, particularly in sheep, that results in economic losses through reduced productivity. BTV is transmitted by the bite of Culicoides spp. midges and is nowadays distributed globally throughout subtropical and even temperate regions. As most viruses, BTV is susceptible to the IFN response, the first line of defense employed by the immune system to combat viral infections. In turn, BTV has evolved strategies to counter the IFN response and promote its replication. The present review we will revise the works describing how BTV interferes with the IFN response. Frontiers Media S.A. 2021-06-08 /pmc/articles/PMC8217435/ /pubmed/34168637 http://dx.doi.org/10.3389/fmicb.2021.692069 Text en Copyright © 2021 Rojas, Avia, Martín and Sevilla. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Microbiology Rojas, José Manuel Avia, Miguel Martín, Verónica Sevilla, Noemí Inhibition of the IFN Response by Bluetongue Virus: The Story So Far |
title | Inhibition of the IFN Response by Bluetongue Virus: The Story So Far |
title_full | Inhibition of the IFN Response by Bluetongue Virus: The Story So Far |
title_fullStr | Inhibition of the IFN Response by Bluetongue Virus: The Story So Far |
title_full_unstemmed | Inhibition of the IFN Response by Bluetongue Virus: The Story So Far |
title_short | Inhibition of the IFN Response by Bluetongue Virus: The Story So Far |
title_sort | inhibition of the ifn response by bluetongue virus: the story so far |
topic | Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8217435/ https://www.ncbi.nlm.nih.gov/pubmed/34168637 http://dx.doi.org/10.3389/fmicb.2021.692069 |
work_keys_str_mv | AT rojasjosemanuel inhibitionoftheifnresponsebybluetonguevirusthestorysofar AT aviamiguel inhibitionoftheifnresponsebybluetonguevirusthestorysofar AT martinveronica inhibitionoftheifnresponsebybluetonguevirusthestorysofar AT sevillanoemi inhibitionoftheifnresponsebybluetonguevirusthestorysofar |