A CAR RNA FISH assay to study functional and spatial heterogeneity of chimeric antigen receptor T cells in tissue

Chimeric antigen receptor (CAR) T cells are engineered cells used in cancer therapy and are studied to treat infectious diseases. Trafficking and persistence of CAR T cells is an important requirement for efficacy to target cancer. Here, we describe a CAR RNA FISH histo-cytometry platform combined w...

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Detalles Bibliográficos
Autores principales: Eichholz, Karsten, Li, Alvason Zhenhua, Diem, Kurt, Jensen, Michael Claus, Zhu, Jia, Corey, Lawrence
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8217486/
https://www.ncbi.nlm.nih.gov/pubmed/34155235
http://dx.doi.org/10.1038/s41598-021-92196-x

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