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Factors associated with prognostic or treatment outcomes in HIV/AIDS patients with and without hypertension in Eswatini
Non-communicable diseases are increasing faster in HIV/AIDS patients than in the general population. We studied the association between hypertension and other possible confounding factors on viral load and CD4-cell counts in hypertensive and non-hypertensive HIV/AIDS patients receiving antiretrovira...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8217509/ https://www.ncbi.nlm.nih.gov/pubmed/34155234 http://dx.doi.org/10.1038/s41598-021-92185-0 |
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author | Dlamini, Sabelo Bonginkosi Dahms, Hans-Uwe Wu, Ming-Tsang |
author_facet | Dlamini, Sabelo Bonginkosi Dahms, Hans-Uwe Wu, Ming-Tsang |
author_sort | Dlamini, Sabelo Bonginkosi |
collection | PubMed |
description | Non-communicable diseases are increasing faster in HIV/AIDS patients than in the general population. We studied the association between hypertension and other possible confounding factors on viral load and CD4-cell counts in hypertensive and non-hypertensive HIV/AIDS patients receiving antiretroviral therapy (ART) at a large hospital in Eswatini over a 4-year period. We performed a retrospective longitudinal review of the medical records of 560 ART patients divided into non-hypertension and hypertension groups (n = 325 and n = 235) from July 27 to September 8, 2018. Generalized Estimated Equation was used to analyze the longitudinal data. Hypertensive patients were more likely to have improved CD4-cell counts than non-hypertensive patients (OR = 1.83, [1.37–2.44]). ART patients with hypertension were more likely to have detectable viral loads, though not significant (OR = 1.37 [0.77–2.43]). In non-hypertensive patients, second line ART was significantly associated with viral load (OR = 8.61 [2.93–25.34]) and adverse side effects (OR = 3.50 [1.06–11.54]), while isoniazid preventive therapy was significantly associated with CD4-cell counts (OR = 1.68 [1.16–2.45]). In hypertensive patients, factors associated with viral load were WHO HIV stage (OR = 2.84 [1.03–7.85]) and adherence (OR = 8.08 [1.33–49.04]). In both groups, CD4-cell counts significantly and steadily increased over time (p-value < 0.001). Results show a significant association between hypertension and CD4 cell counts but not viral load. In ART patients with and without hypertension, the factors associated with prognostic markers were different. More attention may need to be paid to ART patients with well controlled HIV status to monitoring and controlling of hypertension status. |
format | Online Article Text |
id | pubmed-8217509 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-82175092021-06-22 Factors associated with prognostic or treatment outcomes in HIV/AIDS patients with and without hypertension in Eswatini Dlamini, Sabelo Bonginkosi Dahms, Hans-Uwe Wu, Ming-Tsang Sci Rep Article Non-communicable diseases are increasing faster in HIV/AIDS patients than in the general population. We studied the association between hypertension and other possible confounding factors on viral load and CD4-cell counts in hypertensive and non-hypertensive HIV/AIDS patients receiving antiretroviral therapy (ART) at a large hospital in Eswatini over a 4-year period. We performed a retrospective longitudinal review of the medical records of 560 ART patients divided into non-hypertension and hypertension groups (n = 325 and n = 235) from July 27 to September 8, 2018. Generalized Estimated Equation was used to analyze the longitudinal data. Hypertensive patients were more likely to have improved CD4-cell counts than non-hypertensive patients (OR = 1.83, [1.37–2.44]). ART patients with hypertension were more likely to have detectable viral loads, though not significant (OR = 1.37 [0.77–2.43]). In non-hypertensive patients, second line ART was significantly associated with viral load (OR = 8.61 [2.93–25.34]) and adverse side effects (OR = 3.50 [1.06–11.54]), while isoniazid preventive therapy was significantly associated with CD4-cell counts (OR = 1.68 [1.16–2.45]). In hypertensive patients, factors associated with viral load were WHO HIV stage (OR = 2.84 [1.03–7.85]) and adherence (OR = 8.08 [1.33–49.04]). In both groups, CD4-cell counts significantly and steadily increased over time (p-value < 0.001). Results show a significant association between hypertension and CD4 cell counts but not viral load. In ART patients with and without hypertension, the factors associated with prognostic markers were different. More attention may need to be paid to ART patients with well controlled HIV status to monitoring and controlling of hypertension status. Nature Publishing Group UK 2021-06-21 /pmc/articles/PMC8217509/ /pubmed/34155234 http://dx.doi.org/10.1038/s41598-021-92185-0 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Dlamini, Sabelo Bonginkosi Dahms, Hans-Uwe Wu, Ming-Tsang Factors associated with prognostic or treatment outcomes in HIV/AIDS patients with and without hypertension in Eswatini |
title | Factors associated with prognostic or treatment outcomes in HIV/AIDS patients with and without hypertension in Eswatini |
title_full | Factors associated with prognostic or treatment outcomes in HIV/AIDS patients with and without hypertension in Eswatini |
title_fullStr | Factors associated with prognostic or treatment outcomes in HIV/AIDS patients with and without hypertension in Eswatini |
title_full_unstemmed | Factors associated with prognostic or treatment outcomes in HIV/AIDS patients with and without hypertension in Eswatini |
title_short | Factors associated with prognostic or treatment outcomes in HIV/AIDS patients with and without hypertension in Eswatini |
title_sort | factors associated with prognostic or treatment outcomes in hiv/aids patients with and without hypertension in eswatini |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8217509/ https://www.ncbi.nlm.nih.gov/pubmed/34155234 http://dx.doi.org/10.1038/s41598-021-92185-0 |
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