METTL3 promotes tumour development by decreasing APC expression mediated by APC mRNA N(6)-methyladenosine-dependent YTHDF binding

The adenomatous polyposis coli (APC) is a frequently mutated tumour suppressor gene in cancers. However, whether APC is regulated at the epitranscriptomic level remains elusive. In this study, we analysed TCGA data and separated 200 paired oesophageal squamous cell carcinoma (ESCC) specimens and the...

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Detalles Bibliográficos
Autores principales: Wang, Wei, Shao, Fei, Yang, Xueying, Wang, Juhong, Zhu, Rongxuan, Yang, Yannan, Zhao, Gaoxiang, Guo, Dong, Sun, Yingli, Wang, Jie, Xue, Qi, Gao, Shugeng, Gao, Yibo, He, Jie, Lu, Zhimin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8217513/
https://www.ncbi.nlm.nih.gov/pubmed/34155197
http://dx.doi.org/10.1038/s41467-021-23501-5

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