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Association Between Allergen Sensitization and Anaphylaxis in Patients Visiting a Pediatric Emergency Department
Background and Objectives: Anaphylaxis, a severe allergic disease, can be triggered by various causes. This study investigated the association between allergic sensitization and anaphylactic symptoms and the severity of anaphylaxis in children. Patients and Methods: A retrospective review of 107 ped...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8217608/ https://www.ncbi.nlm.nih.gov/pubmed/34169047 http://dx.doi.org/10.3389/fped.2021.651375 |
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author | Lee, Won Seok Cha, Lily Myung-Jin Han, Man Yong Lee, Kyung Suk |
author_facet | Lee, Won Seok Cha, Lily Myung-Jin Han, Man Yong Lee, Kyung Suk |
author_sort | Lee, Won Seok |
collection | PubMed |
description | Background and Objectives: Anaphylaxis, a severe allergic disease, can be triggered by various causes. This study investigated the association between allergic sensitization and anaphylactic symptoms and the severity of anaphylaxis in children. Patients and Methods: A retrospective review of 107 pediatric patients with anaphylaxis was performed between January 1, 2015, and December 31, 2017; 74 patients underwent allergen testing for specific immunoglobulin E. Allergic sensitizations and associations with anaphylactic symptoms and severity were investigated. Results: Overall, 64 (86.5%) patients were sensitized to food or inhalant allergens. In children under 2 years of age, 90.5% were sensitized to food (P = 0.001); in those over 6 years of age, 84.6% were sensitized to inhalant allergens (P = 0.001). Milk sensitization was significantly associated with severe anaphylaxis (P = 0.036). The following symptoms showed significant associations with certain allergen sensitizations: facial edema with food; wheezing with milk; dyspnea with mite, etc. Certain allergen sensitizations presenting as risk factors for anaphylactic symptoms: wheat (adjusted odds ratio [aOR] = 4.644, P = 0.044) and nuts (aOR=3.614, P = 0.041) for wheezing, nuts (aOR=5.201, P = 0.026) for dyspnea, and milk (aOR=4.712, P = 0.048) for vomiting. Conclusion: The allergen sensitization status differed according to the age of the children experiencing anaphylaxis. The severity, symptoms, and signs of anaphylaxis differed depending on the allergen sensitization status. |
format | Online Article Text |
id | pubmed-8217608 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-82176082021-06-23 Association Between Allergen Sensitization and Anaphylaxis in Patients Visiting a Pediatric Emergency Department Lee, Won Seok Cha, Lily Myung-Jin Han, Man Yong Lee, Kyung Suk Front Pediatr Pediatrics Background and Objectives: Anaphylaxis, a severe allergic disease, can be triggered by various causes. This study investigated the association between allergic sensitization and anaphylactic symptoms and the severity of anaphylaxis in children. Patients and Methods: A retrospective review of 107 pediatric patients with anaphylaxis was performed between January 1, 2015, and December 31, 2017; 74 patients underwent allergen testing for specific immunoglobulin E. Allergic sensitizations and associations with anaphylactic symptoms and severity were investigated. Results: Overall, 64 (86.5%) patients were sensitized to food or inhalant allergens. In children under 2 years of age, 90.5% were sensitized to food (P = 0.001); in those over 6 years of age, 84.6% were sensitized to inhalant allergens (P = 0.001). Milk sensitization was significantly associated with severe anaphylaxis (P = 0.036). The following symptoms showed significant associations with certain allergen sensitizations: facial edema with food; wheezing with milk; dyspnea with mite, etc. Certain allergen sensitizations presenting as risk factors for anaphylactic symptoms: wheat (adjusted odds ratio [aOR] = 4.644, P = 0.044) and nuts (aOR=3.614, P = 0.041) for wheezing, nuts (aOR=5.201, P = 0.026) for dyspnea, and milk (aOR=4.712, P = 0.048) for vomiting. Conclusion: The allergen sensitization status differed according to the age of the children experiencing anaphylaxis. The severity, symptoms, and signs of anaphylaxis differed depending on the allergen sensitization status. Frontiers Media S.A. 2021-06-08 /pmc/articles/PMC8217608/ /pubmed/34169047 http://dx.doi.org/10.3389/fped.2021.651375 Text en Copyright © 2021 Lee, Cha, Han and Lee. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pediatrics Lee, Won Seok Cha, Lily Myung-Jin Han, Man Yong Lee, Kyung Suk Association Between Allergen Sensitization and Anaphylaxis in Patients Visiting a Pediatric Emergency Department |
title | Association Between Allergen Sensitization and Anaphylaxis in Patients Visiting a Pediatric Emergency Department |
title_full | Association Between Allergen Sensitization and Anaphylaxis in Patients Visiting a Pediatric Emergency Department |
title_fullStr | Association Between Allergen Sensitization and Anaphylaxis in Patients Visiting a Pediatric Emergency Department |
title_full_unstemmed | Association Between Allergen Sensitization and Anaphylaxis in Patients Visiting a Pediatric Emergency Department |
title_short | Association Between Allergen Sensitization and Anaphylaxis in Patients Visiting a Pediatric Emergency Department |
title_sort | association between allergen sensitization and anaphylaxis in patients visiting a pediatric emergency department |
topic | Pediatrics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8217608/ https://www.ncbi.nlm.nih.gov/pubmed/34169047 http://dx.doi.org/10.3389/fped.2021.651375 |
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