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SARS-COV-2 Infection and Specific Antibody Detection on Health Care Workers from a Military Hospital in Madrid, Spain

This study aims to assess the COVID-19 seroprevalence in HCW at the Hospital Central de la Defensa Gómez Ulla (HCDGU) (Madrid). From 27 April to 10 June 2020 nasopharyngeal swab and serum samples from employees were processed in order to evaluate their seroprevalence and infective situation. Employe...

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Autores principales: Simón Sacristán, María, Ybarra de Villavicencio, Carmen, Collazos Blanco, Ana, Mayo Montero, María Elga, Ariñez Fernández, María del Carmen, Suárez Prieto, Adolfo, Zamora Cintas, María Isabel, Mateo Maestre, María
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8217776/
https://www.ncbi.nlm.nih.gov/pubmed/34156544
http://dx.doi.org/10.1007/s00284-021-02541-6
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author Simón Sacristán, María
Ybarra de Villavicencio, Carmen
Collazos Blanco, Ana
Mayo Montero, María Elga
Ariñez Fernández, María del Carmen
Suárez Prieto, Adolfo
Zamora Cintas, María Isabel
Mateo Maestre, María
author_facet Simón Sacristán, María
Ybarra de Villavicencio, Carmen
Collazos Blanco, Ana
Mayo Montero, María Elga
Ariñez Fernández, María del Carmen
Suárez Prieto, Adolfo
Zamora Cintas, María Isabel
Mateo Maestre, María
author_sort Simón Sacristán, María
collection PubMed
description This study aims to assess the COVID-19 seroprevalence in HCW at the Hospital Central de la Defensa Gómez Ulla (HCDGU) (Madrid). From 27 April to 10 June 2020 nasopharyngeal swab and serum samples from employees were processed in order to evaluate their seroprevalence and infective situation. Employees were classified according to their exposure to SARS-CoV-2 infection as high, moderate, and low exposure groups (level 1, level 2, and level 3, respectively). A specific real-time polymerase chain reaction (RT-PCR) was run to diagnose each patient, whereas the qualitative detection of IgG antibodies to SARS-CoV-2 was performed by means of an immunoassay. In total, 2781 HCW were screened. From this sample, 30 employees (1.1%) were infected with SARS-CoV-2 and 450 (16.2%) were positive to SARS-CoV-2-IgG antibodies. The seroprevalence was higher in the high exposure group.The seroprevalence of antibodies against SARS-CoV-2 among employees without any COVID-19 training was higher than in those who received COVID-19 training (14.5% vs 18.6%, P = 0.035). The seroprevalence in military and civilian personnel in level 1 was 18.2% and 20.0%, respectively (P = 0.4616), while in level 2 it was 6.0% and 16.0% (P = 0.0008) and in level 3 it was 16.7% and 10.2% (P = 0.0315). The results from the present study have shown that the high exposure group and HCW not receiving specific training against COVID-19 showed higher seroprevalence. Furthermore, the military employees from this hospital presented low percentage of seroprevalence.
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spelling pubmed-82177762021-06-23 SARS-COV-2 Infection and Specific Antibody Detection on Health Care Workers from a Military Hospital in Madrid, Spain Simón Sacristán, María Ybarra de Villavicencio, Carmen Collazos Blanco, Ana Mayo Montero, María Elga Ariñez Fernández, María del Carmen Suárez Prieto, Adolfo Zamora Cintas, María Isabel Mateo Maestre, María Curr Microbiol Short Communication This study aims to assess the COVID-19 seroprevalence in HCW at the Hospital Central de la Defensa Gómez Ulla (HCDGU) (Madrid). From 27 April to 10 June 2020 nasopharyngeal swab and serum samples from employees were processed in order to evaluate their seroprevalence and infective situation. Employees were classified according to their exposure to SARS-CoV-2 infection as high, moderate, and low exposure groups (level 1, level 2, and level 3, respectively). A specific real-time polymerase chain reaction (RT-PCR) was run to diagnose each patient, whereas the qualitative detection of IgG antibodies to SARS-CoV-2 was performed by means of an immunoassay. In total, 2781 HCW were screened. From this sample, 30 employees (1.1%) were infected with SARS-CoV-2 and 450 (16.2%) were positive to SARS-CoV-2-IgG antibodies. The seroprevalence was higher in the high exposure group.The seroprevalence of antibodies against SARS-CoV-2 among employees without any COVID-19 training was higher than in those who received COVID-19 training (14.5% vs 18.6%, P = 0.035). The seroprevalence in military and civilian personnel in level 1 was 18.2% and 20.0%, respectively (P = 0.4616), while in level 2 it was 6.0% and 16.0% (P = 0.0008) and in level 3 it was 16.7% and 10.2% (P = 0.0315). The results from the present study have shown that the high exposure group and HCW not receiving specific training against COVID-19 showed higher seroprevalence. Furthermore, the military employees from this hospital presented low percentage of seroprevalence. Springer US 2021-06-22 2021 /pmc/articles/PMC8217776/ /pubmed/34156544 http://dx.doi.org/10.1007/s00284-021-02541-6 Text en © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Short Communication
Simón Sacristán, María
Ybarra de Villavicencio, Carmen
Collazos Blanco, Ana
Mayo Montero, María Elga
Ariñez Fernández, María del Carmen
Suárez Prieto, Adolfo
Zamora Cintas, María Isabel
Mateo Maestre, María
SARS-COV-2 Infection and Specific Antibody Detection on Health Care Workers from a Military Hospital in Madrid, Spain
title SARS-COV-2 Infection and Specific Antibody Detection on Health Care Workers from a Military Hospital in Madrid, Spain
title_full SARS-COV-2 Infection and Specific Antibody Detection on Health Care Workers from a Military Hospital in Madrid, Spain
title_fullStr SARS-COV-2 Infection and Specific Antibody Detection on Health Care Workers from a Military Hospital in Madrid, Spain
title_full_unstemmed SARS-COV-2 Infection and Specific Antibody Detection on Health Care Workers from a Military Hospital in Madrid, Spain
title_short SARS-COV-2 Infection and Specific Antibody Detection on Health Care Workers from a Military Hospital in Madrid, Spain
title_sort sars-cov-2 infection and specific antibody detection on health care workers from a military hospital in madrid, spain
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8217776/
https://www.ncbi.nlm.nih.gov/pubmed/34156544
http://dx.doi.org/10.1007/s00284-021-02541-6
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