Long Noncoding RNAs: Novel Important Players in Adipocyte Lipid Metabolism and Derivative Diseases

Obesity, a global public health issue, is characterized by excessive adiposity and is strongly related to some chronic diseases including cardiovascular diseases and diabetes. Extra energy intake-induced adipogenesis involves various transcription factors and long noncoding RNAs (lncRNAs) that contr...

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Autores principales: Zhang, Bin, Xu, Saijun, Liu, Jinyan, Xie, Yong, Xiaobo, Sun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8217837/
https://www.ncbi.nlm.nih.gov/pubmed/34168572
http://dx.doi.org/10.3389/fphys.2021.691824
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author Zhang, Bin
Xu, Saijun
Liu, Jinyan
Xie, Yong
Xiaobo, Sun
author_facet Zhang, Bin
Xu, Saijun
Liu, Jinyan
Xie, Yong
Xiaobo, Sun
author_sort Zhang, Bin
collection PubMed
description Obesity, a global public health issue, is characterized by excessive adiposity and is strongly related to some chronic diseases including cardiovascular diseases and diabetes. Extra energy intake-induced adipogenesis involves various transcription factors and long noncoding RNAs (lncRNAs) that control lipogenic mRNA expression. Currently, lncRNAs draw much attention for their contribution to adipogenesis and adipose tissue function. Increasing evidence also manifests the pivotal role of lncRNAs in modulating white, brown, and beige adipose tissue development and affecting the progression of the diseases induced by adipose dysfunction. The aim of this review is to summarize the roles of lncRNAs in adipose tissue development and obesity-caused diseases to provide novel drug targets for the treatment of obesity and metabolic diseases.
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spelling pubmed-82178372021-06-23 Long Noncoding RNAs: Novel Important Players in Adipocyte Lipid Metabolism and Derivative Diseases Zhang, Bin Xu, Saijun Liu, Jinyan Xie, Yong Xiaobo, Sun Front Physiol Physiology Obesity, a global public health issue, is characterized by excessive adiposity and is strongly related to some chronic diseases including cardiovascular diseases and diabetes. Extra energy intake-induced adipogenesis involves various transcription factors and long noncoding RNAs (lncRNAs) that control lipogenic mRNA expression. Currently, lncRNAs draw much attention for their contribution to adipogenesis and adipose tissue function. Increasing evidence also manifests the pivotal role of lncRNAs in modulating white, brown, and beige adipose tissue development and affecting the progression of the diseases induced by adipose dysfunction. The aim of this review is to summarize the roles of lncRNAs in adipose tissue development and obesity-caused diseases to provide novel drug targets for the treatment of obesity and metabolic diseases. Frontiers Media S.A. 2021-06-08 /pmc/articles/PMC8217837/ /pubmed/34168572 http://dx.doi.org/10.3389/fphys.2021.691824 Text en Copyright © 2021 Zhang, Xu, Liu, Xie and Xiaobo. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Zhang, Bin
Xu, Saijun
Liu, Jinyan
Xie, Yong
Xiaobo, Sun
Long Noncoding RNAs: Novel Important Players in Adipocyte Lipid Metabolism and Derivative Diseases
title Long Noncoding RNAs: Novel Important Players in Adipocyte Lipid Metabolism and Derivative Diseases
title_full Long Noncoding RNAs: Novel Important Players in Adipocyte Lipid Metabolism and Derivative Diseases
title_fullStr Long Noncoding RNAs: Novel Important Players in Adipocyte Lipid Metabolism and Derivative Diseases
title_full_unstemmed Long Noncoding RNAs: Novel Important Players in Adipocyte Lipid Metabolism and Derivative Diseases
title_short Long Noncoding RNAs: Novel Important Players in Adipocyte Lipid Metabolism and Derivative Diseases
title_sort long noncoding rnas: novel important players in adipocyte lipid metabolism and derivative diseases
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8217837/
https://www.ncbi.nlm.nih.gov/pubmed/34168572
http://dx.doi.org/10.3389/fphys.2021.691824
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