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Longitudinal relation between blood pressure, antihypertensive use and cerebral blood flow, using arterial spin labelling MRI

Consistent cerebral blood flow (CBF) is fundamental to brain function. Cerebral autoregulation ensures CBF stability. Chronic hypertension can lead to disrupted cerebral autoregulation in older people, potentially leading to blood pressure levels interfering with CBF. This study tested whether low B...

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Autores principales: van Dalen, Jan Willem, Mutsaerts, Henri JMM, Petr, Jan, Caan, Matthan WA, van Charante, Eric P Moll, MacIntosh, Bradley J, van Gool, Willem A, Nederveen, Aart J, Richard, Edo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8217888/
https://www.ncbi.nlm.nih.gov/pubmed/33325767
http://dx.doi.org/10.1177/0271678X20966975
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author van Dalen, Jan Willem
Mutsaerts, Henri JMM
Petr, Jan
Caan, Matthan WA
van Charante, Eric P Moll
MacIntosh, Bradley J
van Gool, Willem A
Nederveen, Aart J
Richard, Edo
author_facet van Dalen, Jan Willem
Mutsaerts, Henri JMM
Petr, Jan
Caan, Matthan WA
van Charante, Eric P Moll
MacIntosh, Bradley J
van Gool, Willem A
Nederveen, Aart J
Richard, Edo
author_sort van Dalen, Jan Willem
collection PubMed
description Consistent cerebral blood flow (CBF) is fundamental to brain function. Cerebral autoregulation ensures CBF stability. Chronic hypertension can lead to disrupted cerebral autoregulation in older people, potentially leading to blood pressure levels interfering with CBF. This study tested whether low BP and AHD use are associated with contemporaneous low CBF, and whether longitudinal change in BP is associated with change in CBF, using arterial spin labelling (ASL) MRI, in a prospective longitudinal cohort of 186 community-dwelling older individuals with hypertension (77 ± 3 years, 53% female), 125 (67%) of whom with 3-year follow-up. Diastolic blood pressure, systolic blood pressure, mean arterial pressure, and pulse pressure were assessed as blood pressure parameters. As additional cerebrovascular marker, we evaluated the ASL signal spatial coefficient of variation (ASL SCoV), a measure of ASL signal heterogeneity that may reflect cerebrovascular health. We found no associations between any of the blood pressure measures and concurrent CBF nor between changes in blood pressure measures and CBF over three-year follow-up. Antihypertensive use was associated with lower grey matter CBF (−5.49 ml/100 g/min, 95%CI = −10.7|−0.27, p = 0.04) and higher ASL SCoV (0.32 SD, 95%CI = 0.12|0.52, p = 0.002). These results warrant future research on the potential relations between antihypertensive use and cerebral perfusion.
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spelling pubmed-82178882021-07-01 Longitudinal relation between blood pressure, antihypertensive use and cerebral blood flow, using arterial spin labelling MRI van Dalen, Jan Willem Mutsaerts, Henri JMM Petr, Jan Caan, Matthan WA van Charante, Eric P Moll MacIntosh, Bradley J van Gool, Willem A Nederveen, Aart J Richard, Edo J Cereb Blood Flow Metab Original Articles Consistent cerebral blood flow (CBF) is fundamental to brain function. Cerebral autoregulation ensures CBF stability. Chronic hypertension can lead to disrupted cerebral autoregulation in older people, potentially leading to blood pressure levels interfering with CBF. This study tested whether low BP and AHD use are associated with contemporaneous low CBF, and whether longitudinal change in BP is associated with change in CBF, using arterial spin labelling (ASL) MRI, in a prospective longitudinal cohort of 186 community-dwelling older individuals with hypertension (77 ± 3 years, 53% female), 125 (67%) of whom with 3-year follow-up. Diastolic blood pressure, systolic blood pressure, mean arterial pressure, and pulse pressure were assessed as blood pressure parameters. As additional cerebrovascular marker, we evaluated the ASL signal spatial coefficient of variation (ASL SCoV), a measure of ASL signal heterogeneity that may reflect cerebrovascular health. We found no associations between any of the blood pressure measures and concurrent CBF nor between changes in blood pressure measures and CBF over three-year follow-up. Antihypertensive use was associated with lower grey matter CBF (−5.49 ml/100 g/min, 95%CI = −10.7|−0.27, p = 0.04) and higher ASL SCoV (0.32 SD, 95%CI = 0.12|0.52, p = 0.002). These results warrant future research on the potential relations between antihypertensive use and cerebral perfusion. SAGE Publications 2020-12-16 2021-07 /pmc/articles/PMC8217888/ /pubmed/33325767 http://dx.doi.org/10.1177/0271678X20966975 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Original Articles
van Dalen, Jan Willem
Mutsaerts, Henri JMM
Petr, Jan
Caan, Matthan WA
van Charante, Eric P Moll
MacIntosh, Bradley J
van Gool, Willem A
Nederveen, Aart J
Richard, Edo
Longitudinal relation between blood pressure, antihypertensive use and cerebral blood flow, using arterial spin labelling MRI
title Longitudinal relation between blood pressure, antihypertensive use and cerebral blood flow, using arterial spin labelling MRI
title_full Longitudinal relation between blood pressure, antihypertensive use and cerebral blood flow, using arterial spin labelling MRI
title_fullStr Longitudinal relation between blood pressure, antihypertensive use and cerebral blood flow, using arterial spin labelling MRI
title_full_unstemmed Longitudinal relation between blood pressure, antihypertensive use and cerebral blood flow, using arterial spin labelling MRI
title_short Longitudinal relation between blood pressure, antihypertensive use and cerebral blood flow, using arterial spin labelling MRI
title_sort longitudinal relation between blood pressure, antihypertensive use and cerebral blood flow, using arterial spin labelling mri
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8217888/
https://www.ncbi.nlm.nih.gov/pubmed/33325767
http://dx.doi.org/10.1177/0271678X20966975
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