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Cerebral arterial pulsatility is linked to hippocampal microvascular function and episodic memory in healthy older adults
Microvascular damage in the hippocampus is emerging as a central cause of cognitive decline and dementia in aging. This could be a consequence of age-related decreases in vascular elasticity, exposing hippocampal capillaries to excessive cardiac-related pulsatile flow that disrupts the blood-brain b...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8217890/ https://www.ncbi.nlm.nih.gov/pubmed/33444091 http://dx.doi.org/10.1177/0271678X20980652 |
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author | Vikner, Tomas Eklund, Anders Karalija, Nina Malm, Jan Riklund, Katrine Lindenberger, Ulman Bäckman, Lars Nyberg, Lars Wåhlin, Anders |
author_facet | Vikner, Tomas Eklund, Anders Karalija, Nina Malm, Jan Riklund, Katrine Lindenberger, Ulman Bäckman, Lars Nyberg, Lars Wåhlin, Anders |
author_sort | Vikner, Tomas |
collection | PubMed |
description | Microvascular damage in the hippocampus is emerging as a central cause of cognitive decline and dementia in aging. This could be a consequence of age-related decreases in vascular elasticity, exposing hippocampal capillaries to excessive cardiac-related pulsatile flow that disrupts the blood-brain barrier and the neurovascular unit. Previous studies have found altered intracranial hemodynamics in cognitive impairment and dementia, as well as negative associations between pulsatility and hippocampal volume. However, evidence linking features of the cerebral arterial flow waveform to hippocampal function is lacking. We used a high-resolution 4D flow MRI approach to estimate global representations of the time-resolved flow waveform in distal cortical arteries and in proximal arteries feeding the brain in healthy older adults. Waveform-based clustering revealed a group of individuals featuring steep systolic onset and high amplitude that had poorer hippocampus-sensitive episodic memory (p = 0.003), lower whole-brain perfusion (p = 0.001), and weaker microvascular low-frequency oscillations in the hippocampus (p = 0.035) and parahippocampal gyrus (p = 0.005), potentially indicating compromised neurovascular unit integrity. Our findings suggest that aberrant hemodynamic forces contribute to cerebral microvascular and hippocampal dysfunction in aging. |
format | Online Article Text |
id | pubmed-8217890 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-82178902021-07-01 Cerebral arterial pulsatility is linked to hippocampal microvascular function and episodic memory in healthy older adults Vikner, Tomas Eklund, Anders Karalija, Nina Malm, Jan Riklund, Katrine Lindenberger, Ulman Bäckman, Lars Nyberg, Lars Wåhlin, Anders J Cereb Blood Flow Metab Original Articles Microvascular damage in the hippocampus is emerging as a central cause of cognitive decline and dementia in aging. This could be a consequence of age-related decreases in vascular elasticity, exposing hippocampal capillaries to excessive cardiac-related pulsatile flow that disrupts the blood-brain barrier and the neurovascular unit. Previous studies have found altered intracranial hemodynamics in cognitive impairment and dementia, as well as negative associations between pulsatility and hippocampal volume. However, evidence linking features of the cerebral arterial flow waveform to hippocampal function is lacking. We used a high-resolution 4D flow MRI approach to estimate global representations of the time-resolved flow waveform in distal cortical arteries and in proximal arteries feeding the brain in healthy older adults. Waveform-based clustering revealed a group of individuals featuring steep systolic onset and high amplitude that had poorer hippocampus-sensitive episodic memory (p = 0.003), lower whole-brain perfusion (p = 0.001), and weaker microvascular low-frequency oscillations in the hippocampus (p = 0.035) and parahippocampal gyrus (p = 0.005), potentially indicating compromised neurovascular unit integrity. Our findings suggest that aberrant hemodynamic forces contribute to cerebral microvascular and hippocampal dysfunction in aging. SAGE Publications 2021-01-14 2021-07 /pmc/articles/PMC8217890/ /pubmed/33444091 http://dx.doi.org/10.1177/0271678X20980652 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Original Articles Vikner, Tomas Eklund, Anders Karalija, Nina Malm, Jan Riklund, Katrine Lindenberger, Ulman Bäckman, Lars Nyberg, Lars Wåhlin, Anders Cerebral arterial pulsatility is linked to hippocampal microvascular function and episodic memory in healthy older adults |
title | Cerebral arterial pulsatility is linked to hippocampal microvascular function and episodic memory in healthy older adults |
title_full | Cerebral arterial pulsatility is linked to hippocampal microvascular function and episodic memory in healthy older adults |
title_fullStr | Cerebral arterial pulsatility is linked to hippocampal microvascular function and episodic memory in healthy older adults |
title_full_unstemmed | Cerebral arterial pulsatility is linked to hippocampal microvascular function and episodic memory in healthy older adults |
title_short | Cerebral arterial pulsatility is linked to hippocampal microvascular function and episodic memory in healthy older adults |
title_sort | cerebral arterial pulsatility is linked to hippocampal microvascular function and episodic memory in healthy older adults |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8217890/ https://www.ncbi.nlm.nih.gov/pubmed/33444091 http://dx.doi.org/10.1177/0271678X20980652 |
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