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Cerebral arterial pulsatility is linked to hippocampal microvascular function and episodic memory in healthy older adults

Microvascular damage in the hippocampus is emerging as a central cause of cognitive decline and dementia in aging. This could be a consequence of age-related decreases in vascular elasticity, exposing hippocampal capillaries to excessive cardiac-related pulsatile flow that disrupts the blood-brain b...

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Autores principales: Vikner, Tomas, Eklund, Anders, Karalija, Nina, Malm, Jan, Riklund, Katrine, Lindenberger, Ulman, Bäckman, Lars, Nyberg, Lars, Wåhlin, Anders
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8217890/
https://www.ncbi.nlm.nih.gov/pubmed/33444091
http://dx.doi.org/10.1177/0271678X20980652
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author Vikner, Tomas
Eklund, Anders
Karalija, Nina
Malm, Jan
Riklund, Katrine
Lindenberger, Ulman
Bäckman, Lars
Nyberg, Lars
Wåhlin, Anders
author_facet Vikner, Tomas
Eklund, Anders
Karalija, Nina
Malm, Jan
Riklund, Katrine
Lindenberger, Ulman
Bäckman, Lars
Nyberg, Lars
Wåhlin, Anders
author_sort Vikner, Tomas
collection PubMed
description Microvascular damage in the hippocampus is emerging as a central cause of cognitive decline and dementia in aging. This could be a consequence of age-related decreases in vascular elasticity, exposing hippocampal capillaries to excessive cardiac-related pulsatile flow that disrupts the blood-brain barrier and the neurovascular unit. Previous studies have found altered intracranial hemodynamics in cognitive impairment and dementia, as well as negative associations between pulsatility and hippocampal volume. However, evidence linking features of the cerebral arterial flow waveform to hippocampal function is lacking. We used a high-resolution 4D flow MRI approach to estimate global representations of the time-resolved flow waveform in distal cortical arteries and in proximal arteries feeding the brain in healthy older adults. Waveform-based clustering revealed a group of individuals featuring steep systolic onset and high amplitude that had poorer hippocampus-sensitive episodic memory (p = 0.003), lower whole-brain perfusion (p = 0.001), and weaker microvascular low-frequency oscillations in the hippocampus (p = 0.035) and parahippocampal gyrus (p = 0.005), potentially indicating compromised neurovascular unit integrity. Our findings suggest that aberrant hemodynamic forces contribute to cerebral microvascular and hippocampal dysfunction in aging.
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spelling pubmed-82178902021-07-01 Cerebral arterial pulsatility is linked to hippocampal microvascular function and episodic memory in healthy older adults Vikner, Tomas Eklund, Anders Karalija, Nina Malm, Jan Riklund, Katrine Lindenberger, Ulman Bäckman, Lars Nyberg, Lars Wåhlin, Anders J Cereb Blood Flow Metab Original Articles Microvascular damage in the hippocampus is emerging as a central cause of cognitive decline and dementia in aging. This could be a consequence of age-related decreases in vascular elasticity, exposing hippocampal capillaries to excessive cardiac-related pulsatile flow that disrupts the blood-brain barrier and the neurovascular unit. Previous studies have found altered intracranial hemodynamics in cognitive impairment and dementia, as well as negative associations between pulsatility and hippocampal volume. However, evidence linking features of the cerebral arterial flow waveform to hippocampal function is lacking. We used a high-resolution 4D flow MRI approach to estimate global representations of the time-resolved flow waveform in distal cortical arteries and in proximal arteries feeding the brain in healthy older adults. Waveform-based clustering revealed a group of individuals featuring steep systolic onset and high amplitude that had poorer hippocampus-sensitive episodic memory (p = 0.003), lower whole-brain perfusion (p = 0.001), and weaker microvascular low-frequency oscillations in the hippocampus (p = 0.035) and parahippocampal gyrus (p = 0.005), potentially indicating compromised neurovascular unit integrity. Our findings suggest that aberrant hemodynamic forces contribute to cerebral microvascular and hippocampal dysfunction in aging. SAGE Publications 2021-01-14 2021-07 /pmc/articles/PMC8217890/ /pubmed/33444091 http://dx.doi.org/10.1177/0271678X20980652 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Original Articles
Vikner, Tomas
Eklund, Anders
Karalija, Nina
Malm, Jan
Riklund, Katrine
Lindenberger, Ulman
Bäckman, Lars
Nyberg, Lars
Wåhlin, Anders
Cerebral arterial pulsatility is linked to hippocampal microvascular function and episodic memory in healthy older adults
title Cerebral arterial pulsatility is linked to hippocampal microvascular function and episodic memory in healthy older adults
title_full Cerebral arterial pulsatility is linked to hippocampal microvascular function and episodic memory in healthy older adults
title_fullStr Cerebral arterial pulsatility is linked to hippocampal microvascular function and episodic memory in healthy older adults
title_full_unstemmed Cerebral arterial pulsatility is linked to hippocampal microvascular function and episodic memory in healthy older adults
title_short Cerebral arterial pulsatility is linked to hippocampal microvascular function and episodic memory in healthy older adults
title_sort cerebral arterial pulsatility is linked to hippocampal microvascular function and episodic memory in healthy older adults
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8217890/
https://www.ncbi.nlm.nih.gov/pubmed/33444091
http://dx.doi.org/10.1177/0271678X20980652
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