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Fulminant granulomatosis with polyangiitis presenting with diffuse alveolar haemorrhage following COVID-19

A 40-year-old man developed granulomatosis with polyangiitis (GPA) following a mild case of COVID-19. Initially, he experienced mild migrating joint pain for 2 months prior to testing positive for SARS-CoV-2 but dramatically worsened following resolution of his infection. The pain continued to progr...

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Autores principales: Lind, Eric, Jameson, Andrew, Kurban, Esaw
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8217953/
https://www.ncbi.nlm.nih.gov/pubmed/34155024
http://dx.doi.org/10.1136/bcr-2021-242628
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author Lind, Eric
Jameson, Andrew
Kurban, Esaw
author_facet Lind, Eric
Jameson, Andrew
Kurban, Esaw
author_sort Lind, Eric
collection PubMed
description A 40-year-old man developed granulomatosis with polyangiitis (GPA) following a mild case of COVID-19. Initially, he experienced mild migrating joint pain for 2 months prior to testing positive for SARS-CoV-2 but dramatically worsened following resolution of his infection. The pain continued to progress until he suddenly develope haemoptysis, prompting him to present to a local hospital. The diagnosis of diffuse alveolar haemorrhage secondary to GPA was confirmed with labs, imaging and histopathology. Precipitous deterioration of GPA with concurrent COVID-19 infection indicates a possible temporal relationship. Since the onset of the pandemic, SARS-CoV-2 has been anecdotally associated with the development of various connective tissue disorders. The overlapping clinical presentations and similar appearance on lung imaging present clinicians with a diagnostic challenge. This underscores the importance of having a high index of suspicion of autoimmune diagnoses in patients who present with new or worsening findings following a COVID-19 infection.
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spelling pubmed-82179532021-07-09 Fulminant granulomatosis with polyangiitis presenting with diffuse alveolar haemorrhage following COVID-19 Lind, Eric Jameson, Andrew Kurban, Esaw BMJ Case Rep Case Report A 40-year-old man developed granulomatosis with polyangiitis (GPA) following a mild case of COVID-19. Initially, he experienced mild migrating joint pain for 2 months prior to testing positive for SARS-CoV-2 but dramatically worsened following resolution of his infection. The pain continued to progress until he suddenly develope haemoptysis, prompting him to present to a local hospital. The diagnosis of diffuse alveolar haemorrhage secondary to GPA was confirmed with labs, imaging and histopathology. Precipitous deterioration of GPA with concurrent COVID-19 infection indicates a possible temporal relationship. Since the onset of the pandemic, SARS-CoV-2 has been anecdotally associated with the development of various connective tissue disorders. The overlapping clinical presentations and similar appearance on lung imaging present clinicians with a diagnostic challenge. This underscores the importance of having a high index of suspicion of autoimmune diagnoses in patients who present with new or worsening findings following a COVID-19 infection. BMJ Publishing Group 2021-06-21 /pmc/articles/PMC8217953/ /pubmed/34155024 http://dx.doi.org/10.1136/bcr-2021-242628 Text en © BMJ Publishing Group Limited 2021. No commercial re-use. See rights and permissions. Published by BMJ. https://bmj.com/coronavirus/usageThis article is made freely available for use in accordance with BMJ’s website terms and conditions for the duration of the covid-19 pandemic or until otherwise determined by BMJ. You may use, download and print the article for any lawful, non-commercial purpose (including text and data mining) provided that all copyright notices and trade marks are retained.
spellingShingle Case Report
Lind, Eric
Jameson, Andrew
Kurban, Esaw
Fulminant granulomatosis with polyangiitis presenting with diffuse alveolar haemorrhage following COVID-19
title Fulminant granulomatosis with polyangiitis presenting with diffuse alveolar haemorrhage following COVID-19
title_full Fulminant granulomatosis with polyangiitis presenting with diffuse alveolar haemorrhage following COVID-19
title_fullStr Fulminant granulomatosis with polyangiitis presenting with diffuse alveolar haemorrhage following COVID-19
title_full_unstemmed Fulminant granulomatosis with polyangiitis presenting with diffuse alveolar haemorrhage following COVID-19
title_short Fulminant granulomatosis with polyangiitis presenting with diffuse alveolar haemorrhage following COVID-19
title_sort fulminant granulomatosis with polyangiitis presenting with diffuse alveolar haemorrhage following covid-19
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8217953/
https://www.ncbi.nlm.nih.gov/pubmed/34155024
http://dx.doi.org/10.1136/bcr-2021-242628
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