E3 ligase MKRN3 is a tumor suppressor regulating PABPC1 ubiquitination in non–small cell lung cancer

Central precocious puberty (CPP), largely caused by germline mutations in the MKRN3 gene, has been epidemiologically linked to cancers. MKRN3 is frequently mutated in non–small cell lung cancers (NSCLCs) with five cohorts. Genomic MKRN3 aberrations are significantly enriched in NSCLC samples harbori...

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Detalles Bibliográficos
Autores principales: Li, Ke, Zheng, Xufen, Tang, Hua, Zang, Yuan-Sheng, Zeng, Chunling, Liu, Xiaoxiao, Shen, Yanying, Pang, Yuzhi, Wang, Simin, Xie, Feifei, Lu, Xiaojing, Luo, Yuxiang, Li, Zhang, Bi, Wenbo, Jia, Xiaona, Huang, Tao, Wei, Rongqiang, Huang, Kenan, Chen, Zihao, Zhu, Qingchen, He, Yi, Zhang, Miaoying, Gu, Zhizhan, Xiao, Yichuan, Zhang, Xiaoyang, Fletcher, Jonathan A., Wang, Yuexiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8217967/
https://www.ncbi.nlm.nih.gov/pubmed/34143182
http://dx.doi.org/10.1084/jem.20210151

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