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Prevalence of focal incidental breast uptake on FDG-PET/CT and risk of malignancy: a systematic review and meta-analysis

BACKGROUND: FDG-PET/CT is increasingly used for oncologic and inflammatory diseases. Focal incidental FDG uptake occurs rarely in breast tissue but has often significant consequences. This study aimed to systematically review literature regarding focal incidental breast uptake (FIBU) on FDG-PET/CT i...

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Autores principales: Aarstad, Else Marie, Nordhaug, Petter, Naghavi-Behzad, Mohammad, Larsen, Lisbet Brønsro, Gerke, Oke, Hildebrandt, Malene Grubbe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8218088/
https://www.ncbi.nlm.nih.gov/pubmed/34191158
http://dx.doi.org/10.1186/s41824-019-0063-5
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author Aarstad, Else Marie
Nordhaug, Petter
Naghavi-Behzad, Mohammad
Larsen, Lisbet Brønsro
Gerke, Oke
Hildebrandt, Malene Grubbe
author_facet Aarstad, Else Marie
Nordhaug, Petter
Naghavi-Behzad, Mohammad
Larsen, Lisbet Brønsro
Gerke, Oke
Hildebrandt, Malene Grubbe
author_sort Aarstad, Else Marie
collection PubMed
description BACKGROUND: FDG-PET/CT is increasingly used for oncologic and inflammatory diseases. Focal incidental FDG uptake occurs rarely in breast tissue but has often significant consequences. This study aimed to systematically review literature regarding focal incidental breast uptake (FIBU) on FDG-PET/CT in order to yield an update on the prevalence and risk of malignancy for FIBU. METHODS: A systematic search for relevant articles published between 2012 and 2018 was performed through MEDLINE, Embase, and Cochrane databases. Studies addressing the detection of FIBU in patients without a previous history of breast malignancy were included. The QUADAS-2 was used for quality assessment, and eligible data were pooled using a fixed-effects model. I(2) was calculated for the heterogeneity between studies. RESULTS: Eight studies containing 180,002 scans were included in the systematic review. The median prevalence of FIBU for both genders was 0.52% (range 0.18–22.5%). Prevalence for women was mentioned separately in five studies and varied from 0.51 to 23.5%. One study reporting a high prevalence was based on patients being staged for known malignancy, and the word “breast” was used in the search, which may have caused selection bias. Data from four studies were eligible for meta-analysis. A high degree of heterogeneity was observed for prevalence data (I(2) of 97.5%), while moderate heterogeneity was observed for data on malignancy risk assessment (I(2) of 62.8%). The pooled prevalence of FIBU in women was 0.61% (range 0.56–0.66%), and the pooled prevalence of malignancy of FIBUs was 38.7% (range 34.4–43.0%). The most commonly detected malignancy was invasive ductal carcinoma. CONCLUSION: FIBU occurs rarely on FDG-PET/CT for female patients but yields a high risk of malignancy according to the results of published papers. Therefore, it should be considered relevant to further elucidate patients with incidentally detected FDG uptake in breast in clinical practice. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s41824-019-0063-5) contains supplementary material, which is available to authorized users.
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spelling pubmed-82180882021-06-24 Prevalence of focal incidental breast uptake on FDG-PET/CT and risk of malignancy: a systematic review and meta-analysis Aarstad, Else Marie Nordhaug, Petter Naghavi-Behzad, Mohammad Larsen, Lisbet Brønsro Gerke, Oke Hildebrandt, Malene Grubbe Eur J Hybrid Imaging Review BACKGROUND: FDG-PET/CT is increasingly used for oncologic and inflammatory diseases. Focal incidental FDG uptake occurs rarely in breast tissue but has often significant consequences. This study aimed to systematically review literature regarding focal incidental breast uptake (FIBU) on FDG-PET/CT in order to yield an update on the prevalence and risk of malignancy for FIBU. METHODS: A systematic search for relevant articles published between 2012 and 2018 was performed through MEDLINE, Embase, and Cochrane databases. Studies addressing the detection of FIBU in patients without a previous history of breast malignancy were included. The QUADAS-2 was used for quality assessment, and eligible data were pooled using a fixed-effects model. I(2) was calculated for the heterogeneity between studies. RESULTS: Eight studies containing 180,002 scans were included in the systematic review. The median prevalence of FIBU for both genders was 0.52% (range 0.18–22.5%). Prevalence for women was mentioned separately in five studies and varied from 0.51 to 23.5%. One study reporting a high prevalence was based on patients being staged for known malignancy, and the word “breast” was used in the search, which may have caused selection bias. Data from four studies were eligible for meta-analysis. A high degree of heterogeneity was observed for prevalence data (I(2) of 97.5%), while moderate heterogeneity was observed for data on malignancy risk assessment (I(2) of 62.8%). The pooled prevalence of FIBU in women was 0.61% (range 0.56–0.66%), and the pooled prevalence of malignancy of FIBUs was 38.7% (range 34.4–43.0%). The most commonly detected malignancy was invasive ductal carcinoma. CONCLUSION: FIBU occurs rarely on FDG-PET/CT for female patients but yields a high risk of malignancy according to the results of published papers. Therefore, it should be considered relevant to further elucidate patients with incidentally detected FDG uptake in breast in clinical practice. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s41824-019-0063-5) contains supplementary material, which is available to authorized users. Springer International Publishing 2019-09-30 /pmc/articles/PMC8218088/ /pubmed/34191158 http://dx.doi.org/10.1186/s41824-019-0063-5 Text en © The Author(s) 2019 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Review
Aarstad, Else Marie
Nordhaug, Petter
Naghavi-Behzad, Mohammad
Larsen, Lisbet Brønsro
Gerke, Oke
Hildebrandt, Malene Grubbe
Prevalence of focal incidental breast uptake on FDG-PET/CT and risk of malignancy: a systematic review and meta-analysis
title Prevalence of focal incidental breast uptake on FDG-PET/CT and risk of malignancy: a systematic review and meta-analysis
title_full Prevalence of focal incidental breast uptake on FDG-PET/CT and risk of malignancy: a systematic review and meta-analysis
title_fullStr Prevalence of focal incidental breast uptake on FDG-PET/CT and risk of malignancy: a systematic review and meta-analysis
title_full_unstemmed Prevalence of focal incidental breast uptake on FDG-PET/CT and risk of malignancy: a systematic review and meta-analysis
title_short Prevalence of focal incidental breast uptake on FDG-PET/CT and risk of malignancy: a systematic review and meta-analysis
title_sort prevalence of focal incidental breast uptake on fdg-pet/ct and risk of malignancy: a systematic review and meta-analysis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8218088/
https://www.ncbi.nlm.nih.gov/pubmed/34191158
http://dx.doi.org/10.1186/s41824-019-0063-5
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