Cargando…

18F-NaF PET/CT imaging of bone formation induced by bioactive glass S53P4 after mastoid obliteration

PURPOSE: Bioactive glass has been successfully used for surgical treatment of chronic infections in bone and bone cavities. Besides infection control, new bone formation is induced by the bioactive glass which is considered to have osteoconductive properties. Evaluation of postsurgical changes after...

Descripción completa

Detalles Bibliográficos
Autores principales: Timmermans, Adriana J., Quak, Jasper J., Hagen, Petronella J., Colnot, David R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8218153/
https://www.ncbi.nlm.nih.gov/pubmed/34191153
http://dx.doi.org/10.1186/s41824-019-0065-3
_version_ 1783710722627207168
author Timmermans, Adriana J.
Quak, Jasper J.
Hagen, Petronella J.
Colnot, David R.
author_facet Timmermans, Adriana J.
Quak, Jasper J.
Hagen, Petronella J.
Colnot, David R.
author_sort Timmermans, Adriana J.
collection PubMed
description PURPOSE: Bioactive glass has been successfully used for surgical treatment of chronic infections in bone and bone cavities. Besides infection control, new bone formation is induced by the bioactive glass which is considered to have osteoconductive properties. Evaluation of postsurgical changes after bone graft surgery is generally performed with conventional radiographs or CT/MR imaging, but 18F-NaF PET/CT might be more suitable since it has a high and rapid bone uptake, accompanied by a fast blood clearance leading to a high bone to background ratio. CASE: Obliteration with S53P4 bioactive glass of the mastoid and middle ear was performed in a patient suffering from chronic otitis media. Control of the chronic otitis media was achieved, and follow-up imaging after 3 years with 18F-NaF PET/CT showed increased uptake in the obliterated cavity indicating new bone formation. CONCLUSION: 18F-NaF PET/CT is able to detect new bone formation after obliteration of the mastoid with S53P4 bioactive glass.
format Online
Article
Text
id pubmed-8218153
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Springer International Publishing
record_format MEDLINE/PubMed
spelling pubmed-82181532021-06-24 18F-NaF PET/CT imaging of bone formation induced by bioactive glass S53P4 after mastoid obliteration Timmermans, Adriana J. Quak, Jasper J. Hagen, Petronella J. Colnot, David R. Eur J Hybrid Imaging Case Report PURPOSE: Bioactive glass has been successfully used for surgical treatment of chronic infections in bone and bone cavities. Besides infection control, new bone formation is induced by the bioactive glass which is considered to have osteoconductive properties. Evaluation of postsurgical changes after bone graft surgery is generally performed with conventional radiographs or CT/MR imaging, but 18F-NaF PET/CT might be more suitable since it has a high and rapid bone uptake, accompanied by a fast blood clearance leading to a high bone to background ratio. CASE: Obliteration with S53P4 bioactive glass of the mastoid and middle ear was performed in a patient suffering from chronic otitis media. Control of the chronic otitis media was achieved, and follow-up imaging after 3 years with 18F-NaF PET/CT showed increased uptake in the obliterated cavity indicating new bone formation. CONCLUSION: 18F-NaF PET/CT is able to detect new bone formation after obliteration of the mastoid with S53P4 bioactive glass. Springer International Publishing 2019-10-31 /pmc/articles/PMC8218153/ /pubmed/34191153 http://dx.doi.org/10.1186/s41824-019-0065-3 Text en © The Author(s) 2019 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Case Report
Timmermans, Adriana J.
Quak, Jasper J.
Hagen, Petronella J.
Colnot, David R.
18F-NaF PET/CT imaging of bone formation induced by bioactive glass S53P4 after mastoid obliteration
title 18F-NaF PET/CT imaging of bone formation induced by bioactive glass S53P4 after mastoid obliteration
title_full 18F-NaF PET/CT imaging of bone formation induced by bioactive glass S53P4 after mastoid obliteration
title_fullStr 18F-NaF PET/CT imaging of bone formation induced by bioactive glass S53P4 after mastoid obliteration
title_full_unstemmed 18F-NaF PET/CT imaging of bone formation induced by bioactive glass S53P4 after mastoid obliteration
title_short 18F-NaF PET/CT imaging of bone formation induced by bioactive glass S53P4 after mastoid obliteration
title_sort 18f-naf pet/ct imaging of bone formation induced by bioactive glass s53p4 after mastoid obliteration
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8218153/
https://www.ncbi.nlm.nih.gov/pubmed/34191153
http://dx.doi.org/10.1186/s41824-019-0065-3
work_keys_str_mv AT timmermansadrianaj 18fnafpetctimagingofboneformationinducedbybioactiveglasss53p4aftermastoidobliteration
AT quakjasperj 18fnafpetctimagingofboneformationinducedbybioactiveglasss53p4aftermastoidobliteration
AT hagenpetronellaj 18fnafpetctimagingofboneformationinducedbybioactiveglasss53p4aftermastoidobliteration
AT colnotdavidr 18fnafpetctimagingofboneformationinducedbybioactiveglasss53p4aftermastoidobliteration