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18F-NaF PET/CT imaging of bone formation induced by bioactive glass S53P4 after mastoid obliteration
PURPOSE: Bioactive glass has been successfully used for surgical treatment of chronic infections in bone and bone cavities. Besides infection control, new bone formation is induced by the bioactive glass which is considered to have osteoconductive properties. Evaluation of postsurgical changes after...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8218153/ https://www.ncbi.nlm.nih.gov/pubmed/34191153 http://dx.doi.org/10.1186/s41824-019-0065-3 |
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author | Timmermans, Adriana J. Quak, Jasper J. Hagen, Petronella J. Colnot, David R. |
author_facet | Timmermans, Adriana J. Quak, Jasper J. Hagen, Petronella J. Colnot, David R. |
author_sort | Timmermans, Adriana J. |
collection | PubMed |
description | PURPOSE: Bioactive glass has been successfully used for surgical treatment of chronic infections in bone and bone cavities. Besides infection control, new bone formation is induced by the bioactive glass which is considered to have osteoconductive properties. Evaluation of postsurgical changes after bone graft surgery is generally performed with conventional radiographs or CT/MR imaging, but 18F-NaF PET/CT might be more suitable since it has a high and rapid bone uptake, accompanied by a fast blood clearance leading to a high bone to background ratio. CASE: Obliteration with S53P4 bioactive glass of the mastoid and middle ear was performed in a patient suffering from chronic otitis media. Control of the chronic otitis media was achieved, and follow-up imaging after 3 years with 18F-NaF PET/CT showed increased uptake in the obliterated cavity indicating new bone formation. CONCLUSION: 18F-NaF PET/CT is able to detect new bone formation after obliteration of the mastoid with S53P4 bioactive glass. |
format | Online Article Text |
id | pubmed-8218153 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-82181532021-06-24 18F-NaF PET/CT imaging of bone formation induced by bioactive glass S53P4 after mastoid obliteration Timmermans, Adriana J. Quak, Jasper J. Hagen, Petronella J. Colnot, David R. Eur J Hybrid Imaging Case Report PURPOSE: Bioactive glass has been successfully used for surgical treatment of chronic infections in bone and bone cavities. Besides infection control, new bone formation is induced by the bioactive glass which is considered to have osteoconductive properties. Evaluation of postsurgical changes after bone graft surgery is generally performed with conventional radiographs or CT/MR imaging, but 18F-NaF PET/CT might be more suitable since it has a high and rapid bone uptake, accompanied by a fast blood clearance leading to a high bone to background ratio. CASE: Obliteration with S53P4 bioactive glass of the mastoid and middle ear was performed in a patient suffering from chronic otitis media. Control of the chronic otitis media was achieved, and follow-up imaging after 3 years with 18F-NaF PET/CT showed increased uptake in the obliterated cavity indicating new bone formation. CONCLUSION: 18F-NaF PET/CT is able to detect new bone formation after obliteration of the mastoid with S53P4 bioactive glass. Springer International Publishing 2019-10-31 /pmc/articles/PMC8218153/ /pubmed/34191153 http://dx.doi.org/10.1186/s41824-019-0065-3 Text en © The Author(s) 2019 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Case Report Timmermans, Adriana J. Quak, Jasper J. Hagen, Petronella J. Colnot, David R. 18F-NaF PET/CT imaging of bone formation induced by bioactive glass S53P4 after mastoid obliteration |
title | 18F-NaF PET/CT imaging of bone formation induced by bioactive glass S53P4 after mastoid obliteration |
title_full | 18F-NaF PET/CT imaging of bone formation induced by bioactive glass S53P4 after mastoid obliteration |
title_fullStr | 18F-NaF PET/CT imaging of bone formation induced by bioactive glass S53P4 after mastoid obliteration |
title_full_unstemmed | 18F-NaF PET/CT imaging of bone formation induced by bioactive glass S53P4 after mastoid obliteration |
title_short | 18F-NaF PET/CT imaging of bone formation induced by bioactive glass S53P4 after mastoid obliteration |
title_sort | 18f-naf pet/ct imaging of bone formation induced by bioactive glass s53p4 after mastoid obliteration |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8218153/ https://www.ncbi.nlm.nih.gov/pubmed/34191153 http://dx.doi.org/10.1186/s41824-019-0065-3 |
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