Cargando…

Application of Poly (Agar-Co-Glycerol-Co-Sweet Almond Oil) Based Organo-Hydrogels as a Drug Delivery Material

In this study, it was aimed to investigate the synthesis, characterization and drug release behaviors of organo-hydrogels containing pH-sensitive Agar (A), Glycerol (G), Sweet Almond oil (Wu et al. in J Mol Struct 882:107–115, 2008). Organo-hydrogels, which contained Agar, Glycerol and different amo...

Descripción completa

Detalles Bibliográficos
Autores principales: Ersen Dudu, Tuba, Alpaslan, Duygu, Aktas, Nahit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8218294/
https://www.ncbi.nlm.nih.gov/pubmed/34177399
http://dx.doi.org/10.1007/s10924-021-02212-4
_version_ 1783710737627086848
author Ersen Dudu, Tuba
Alpaslan, Duygu
Aktas, Nahit
author_facet Ersen Dudu, Tuba
Alpaslan, Duygu
Aktas, Nahit
author_sort Ersen Dudu, Tuba
collection PubMed
description In this study, it was aimed to investigate the synthesis, characterization and drug release behaviors of organo-hydrogels containing pH-sensitive Agar (A), Glycerol (G), Sweet Almond oil (Wu et al. in J Mol Struct 882:107–115, 2008). Organo-hydrogels, which contained Agar, Glycerol and different amounts of Sweet Almond oil, were synthesized via the free-radical polymerization reaction with emulsion technique using glutaraldehyde or methylene bis acrylamide crosslinkers. Then, the degree of swelling, bond structures, blood compatibility and antioxidant properties of the synthesized organo-hydrogels were examined. In addition, Organo-hydrogels which loaded with Ceftriaxone and Oxaliplatin were synthesized with the same polymerization reaction and release kinetics were investigated. In vitro release studies were performed at media similar pH to gastric fluid (pH 2.0), skin surface (pH 5.5), blood fluid (pH 7.4) and intestinal fluid (pH 8.0), at 37 °C. The effects on release of crosslinker type and sweet almond oil amount were investigated. Kinetic parameters were determined using release results and these results were applied to zero and first-order equations and Korsmeyer-Peppas and Higuchi equations. Diffusion exponential was calculated for drug diffusion of organo-hydrogels and values consistent with release results were found.
format Online
Article
Text
id pubmed-8218294
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Springer US
record_format MEDLINE/PubMed
spelling pubmed-82182942021-06-23 Application of Poly (Agar-Co-Glycerol-Co-Sweet Almond Oil) Based Organo-Hydrogels as a Drug Delivery Material Ersen Dudu, Tuba Alpaslan, Duygu Aktas, Nahit J Polym Environ Original Paper In this study, it was aimed to investigate the synthesis, characterization and drug release behaviors of organo-hydrogels containing pH-sensitive Agar (A), Glycerol (G), Sweet Almond oil (Wu et al. in J Mol Struct 882:107–115, 2008). Organo-hydrogels, which contained Agar, Glycerol and different amounts of Sweet Almond oil, were synthesized via the free-radical polymerization reaction with emulsion technique using glutaraldehyde or methylene bis acrylamide crosslinkers. Then, the degree of swelling, bond structures, blood compatibility and antioxidant properties of the synthesized organo-hydrogels were examined. In addition, Organo-hydrogels which loaded with Ceftriaxone and Oxaliplatin were synthesized with the same polymerization reaction and release kinetics were investigated. In vitro release studies were performed at media similar pH to gastric fluid (pH 2.0), skin surface (pH 5.5), blood fluid (pH 7.4) and intestinal fluid (pH 8.0), at 37 °C. The effects on release of crosslinker type and sweet almond oil amount were investigated. Kinetic parameters were determined using release results and these results were applied to zero and first-order equations and Korsmeyer-Peppas and Higuchi equations. Diffusion exponential was calculated for drug diffusion of organo-hydrogels and values consistent with release results were found. Springer US 2021-06-22 2022 /pmc/articles/PMC8218294/ /pubmed/34177399 http://dx.doi.org/10.1007/s10924-021-02212-4 Text en © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Original Paper
Ersen Dudu, Tuba
Alpaslan, Duygu
Aktas, Nahit
Application of Poly (Agar-Co-Glycerol-Co-Sweet Almond Oil) Based Organo-Hydrogels as a Drug Delivery Material
title Application of Poly (Agar-Co-Glycerol-Co-Sweet Almond Oil) Based Organo-Hydrogels as a Drug Delivery Material
title_full Application of Poly (Agar-Co-Glycerol-Co-Sweet Almond Oil) Based Organo-Hydrogels as a Drug Delivery Material
title_fullStr Application of Poly (Agar-Co-Glycerol-Co-Sweet Almond Oil) Based Organo-Hydrogels as a Drug Delivery Material
title_full_unstemmed Application of Poly (Agar-Co-Glycerol-Co-Sweet Almond Oil) Based Organo-Hydrogels as a Drug Delivery Material
title_short Application of Poly (Agar-Co-Glycerol-Co-Sweet Almond Oil) Based Organo-Hydrogels as a Drug Delivery Material
title_sort application of poly (agar-co-glycerol-co-sweet almond oil) based organo-hydrogels as a drug delivery material
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8218294/
https://www.ncbi.nlm.nih.gov/pubmed/34177399
http://dx.doi.org/10.1007/s10924-021-02212-4
work_keys_str_mv AT ersendudutuba applicationofpolyagarcoglycerolcosweetalmondoilbasedorganohydrogelsasadrugdeliverymaterial
AT alpaslanduygu applicationofpolyagarcoglycerolcosweetalmondoilbasedorganohydrogelsasadrugdeliverymaterial
AT aktasnahit applicationofpolyagarcoglycerolcosweetalmondoilbasedorganohydrogelsasadrugdeliverymaterial