Post‐transfusion hyperhemolysis syndrome in a patient with beta thalassemia major

Hyperhemolysis syndrome (HS) is characterized by the occurrence of severe anemia with post‐transfusion hemoglobin and hematocrit levels being markedly lower than those present prior to transfusion. A high index of suspicion of HS in a multi‐transfused thalassemia patient allows prompt institution of therapy resulting in improved survival outcome.