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Update on the management and treatment of viral hepatitis

This review aims to summarize the current evidence on the treatment of viral hepatitis, focusing on its clinical management. Also, future treatment options and areas of potential research interest are detailed. PubMed and Scopus databases were searched for primary studies published within the last t...

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Autores principales: Almeida, Patricia Holanda, Matielo, Celso E L, Curvelo, Lilian A, Rocco, Rodrigo A, Felga, Guilherme, Della Guardia, Bianca, Boteon, Yuri L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8218370/
https://www.ncbi.nlm.nih.gov/pubmed/34163109
http://dx.doi.org/10.3748/wjg.v27.i23.3249
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author Almeida, Patricia Holanda
Matielo, Celso E L
Curvelo, Lilian A
Rocco, Rodrigo A
Felga, Guilherme
Della Guardia, Bianca
Boteon, Yuri L
author_facet Almeida, Patricia Holanda
Matielo, Celso E L
Curvelo, Lilian A
Rocco, Rodrigo A
Felga, Guilherme
Della Guardia, Bianca
Boteon, Yuri L
author_sort Almeida, Patricia Holanda
collection PubMed
description This review aims to summarize the current evidence on the treatment of viral hepatitis, focusing on its clinical management. Also, future treatment options and areas of potential research interest are detailed. PubMed and Scopus databases were searched for primary studies published within the last ten years. Keywords included hepatitis A virus, hepatitis B virus (HBV), hepatitis C virus, hepatitis D virus (HDV), hepatitis E virus, and treatment. Outcomes reported in the studies were summarized, tabulated, and synthesized. Significant advances in viral hepatitis treatment were accomplished, such as the advent of curative therapies for hepatitis C and the development and improvement of hepatitis A, hepatitis B, and hepatitis E vaccination. Drugs that cure hepatitis B, going beyond viral suppression, are so far unavailable; however, targeted antiviral drugs against HBV (immunomodulatory therapies and gene silencing technologies) are promising approaches to eradicating the virus. Ultimately, high vaccination coverage and large-scale test-and-treat programmes with high screening rates may eliminate viral hepatitis and mitigate their burden on health systems. The development of curative hepatitis C treatment renewed the enthusiasm for curing hepatitis B, albeit further investigation is required. Novel therapeutic options targeting HDV life cycle are currently under clinical investigation.
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spelling pubmed-82183702021-06-22 Update on the management and treatment of viral hepatitis Almeida, Patricia Holanda Matielo, Celso E L Curvelo, Lilian A Rocco, Rodrigo A Felga, Guilherme Della Guardia, Bianca Boteon, Yuri L World J Gastroenterol Minireviews This review aims to summarize the current evidence on the treatment of viral hepatitis, focusing on its clinical management. Also, future treatment options and areas of potential research interest are detailed. PubMed and Scopus databases were searched for primary studies published within the last ten years. Keywords included hepatitis A virus, hepatitis B virus (HBV), hepatitis C virus, hepatitis D virus (HDV), hepatitis E virus, and treatment. Outcomes reported in the studies were summarized, tabulated, and synthesized. Significant advances in viral hepatitis treatment were accomplished, such as the advent of curative therapies for hepatitis C and the development and improvement of hepatitis A, hepatitis B, and hepatitis E vaccination. Drugs that cure hepatitis B, going beyond viral suppression, are so far unavailable; however, targeted antiviral drugs against HBV (immunomodulatory therapies and gene silencing technologies) are promising approaches to eradicating the virus. Ultimately, high vaccination coverage and large-scale test-and-treat programmes with high screening rates may eliminate viral hepatitis and mitigate their burden on health systems. The development of curative hepatitis C treatment renewed the enthusiasm for curing hepatitis B, albeit further investigation is required. Novel therapeutic options targeting HDV life cycle are currently under clinical investigation. Baishideng Publishing Group Inc 2021-06-21 2021-06-21 /pmc/articles/PMC8218370/ /pubmed/34163109 http://dx.doi.org/10.3748/wjg.v27.i23.3249 Text en ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
spellingShingle Minireviews
Almeida, Patricia Holanda
Matielo, Celso E L
Curvelo, Lilian A
Rocco, Rodrigo A
Felga, Guilherme
Della Guardia, Bianca
Boteon, Yuri L
Update on the management and treatment of viral hepatitis
title Update on the management and treatment of viral hepatitis
title_full Update on the management and treatment of viral hepatitis
title_fullStr Update on the management and treatment of viral hepatitis
title_full_unstemmed Update on the management and treatment of viral hepatitis
title_short Update on the management and treatment of viral hepatitis
title_sort update on the management and treatment of viral hepatitis
topic Minireviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8218370/
https://www.ncbi.nlm.nih.gov/pubmed/34163109
http://dx.doi.org/10.3748/wjg.v27.i23.3249
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