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Aging and high-fat diet feeding lead to peripheral insulin resistance and sex-dependent changes in brain of mouse model of tau pathology THY-Tau22

BACKGROUND: Obesity leads to low-grade inflammation in the adipose tissue and liver and neuroinflammation in the brain. Obesity-induced insulin resistance (IR) and neuroinflammation seem to intensify neurodegeneration including Alzheimer’s disease. In this study, the impact of high-fat (HF) diet-ind...

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Detalles Bibliográficos
Autores principales:	Kacířová, Miroslava, Železná, Blanka, Blažková, Michaela, Holubová, Martina, Popelová, Andrea, Kuneš, Jaroslav, Šedivá, Blanka, Maletínská, Lenka
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8218481/ https://www.ncbi.nlm.nih.gov/pubmed/34158075 http://dx.doi.org/10.1186/s12974-021-02190-3

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