Frequent POLE-driven hypermutation in ovarian endometrioid cancer revealed by mutational signatures in RNA sequencing

BACKGROUND: DNA polymerase epsilon (POLE) is encoded by the POLE gene, and POLE-driven tumors are characterized by high mutational rates. POLE-driven tumors are relatively common in endometrial and colorectal cancer, and their presence is increasingly recognized in ovarian cancer (OC) of endometrioi...

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Detalles Bibliográficos
Autores principales: Davila, Jaime I., Chanana, Pritha, Sarangi, Vivekananda, Fogarty, Zachary C., Weroha, S. John, Guo, Ruifeng, Goode, Ellen L., Huang, Yajue, Wang, Chen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8218518/
https://www.ncbi.nlm.nih.gov/pubmed/34158040
http://dx.doi.org/10.1186/s12920-021-01017-7

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