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Structure-guided design of a perampanel-derived pharmacophore targeting the SARS-CoV-2 main protease

There is a clinical need for direct-acting antivirals targeting SARS-CoV-2, the coronavirus responsible for the COVID-19 pandemic, to complement current therapeutic strategies. The main protease (M(pro)) is an attractive target for antiviral therapy. However, the vast majority of protease inhibitors...

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Detalles Bibliográficos
Autores principales:	Deshmukh, Maya G., Ippolito, Joseph A., Zhang, Chun-Hui, Stone, Elizabeth A., Reilly, Raquel A., Miller, Scott J., Jorgensen, William L., Anderson, Karen S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier Ltd. 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8218531/ https://www.ncbi.nlm.nih.gov/pubmed/34161756 http://dx.doi.org/10.1016/j.str.2021.06.002

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