Cargando…

Characterization of KPC-82, a KPC-2 Variant Conferring Resistance to Ceftazidime-Avibactam in a Carbapenem-Nonsusceptible Clinical Isolate of Citrobacter koseri

KPC-82 is a KPC-2 variant identified in a carbapenem-nonsusceptible Citrobacter koseri that confers high-level resistance to ceftazidime-avibactam. Genomic analysis revealed that bla(KPC-82) is carried by a chromosomally integrated Tn4401 transposon (disrupting porin gene phoE) and evolved by a 6-nu...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lebreton, Francois, Corey, Brendan W., McElheny, Christi L., Iovleva, Alina, Preston, Lan, Margulieux, Katie R., Cybulski, Robert J., Mc Gann, Patrick, Doi, Yohei, Bennett, Jason W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2021
Materias:	Mechanisms of Resistance
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8218621/ https://www.ncbi.nlm.nih.gov/pubmed/33972237 http://dx.doi.org/10.1128/AAC.00150-21

Ejemplares similares

Identification of a Novel Ceftazidime-Avibactam-Resistant KPC-2 Variant, KPC-123, in Citrobacter koseri Following Ceftazidime-Avibactam Treatment
por: Wang, Lin, et al.
Publicado: (2022)

Potency of Vaborbactam Is Less Affected than That of Avibactam in Strains Producing KPC-2 Mutations That Confer Resistance to Ceftazidime-Avibactam
por: Tsivkovski, Ruslan, et al.
Publicado: (2020)

The Effect of β-Lactam Antibiotics on the Evolution of Ceftazidime/Avibactam and Cefiderocol Resistance in KPC-Producing Klebsiella pneumoniae
por: Zhang, Ping, et al.
Publicado: (2023)

Draft Genome Sequences of bla(KPC)-Containing Enterobacter aerogenes, Citrobacter freundii, and Citrobacter koseri Strains
por: Hazen, Tracy H., et al.
Publicado: (2018)

Multiplicity of bla(KPC) Genes and pKpQIL Plasmid Plasticity in the Development of Ceftazidime-Avibactam and Meropenem Coresistance in Klebsiella pneumoniae Sequence Type 307
por: Arcari, Gabriele, et al.
Publicado: (2023)

A Novel Plasmid Entry Exclusion System in pKPC_UVA01, a Promiscuous Conjugative Plasmid Carrying the bla(KPC) Carbapenemase Gene
por: Kamruzzaman, Muhammad, et al.
Publicado: (2022)

Meropenem-Vaborbactam Resistance Selection, Resistance Prevention, and Molecular Mechanisms in Mutants of KPC-Producing Klebsiella pneumoniae
por: Sun, Dongxu, et al.
Publicado: (2017)

Boronic Acid Transition State Inhibitors as Potent Inactivators of KPC and CTX-M β-Lactamases: Biochemical and Structural Analyses
por: Alsenani, Tahani A., et al.
Publicado: (2023)

Klebsiella pneumoniae Carbapenemase (KPC)-Producing K. pneumoniae at a Single Institution: Insights into Endemicity from Whole-Genome Sequencing
por: Mathers, Amy J., et al.
Publicado: (2015)

In vitro Optimization of Ceftazidime/Avibactam for KPC-Producing Klebsiella pneumoniae
por: Huang, Yanqin, et al.
Publicado: (2021)

Prevalence of Slow-Growth Vancomycin Nonsusceptibility in Methicillin-Resistant Staphylococcus aureus
por: Katayama, Yuki, et al.
Publicado: (2017)

β-Lactamase Characterization of Gram-Negative Pathogens Recovered from Patients Enrolled in the Phase 2 Trials for Ceftazidime-Avibactam: Clinical Efficacies Analyzed against Subsets of Molecularly Characterized Isolates
por: Mendes, Rodrigo E., et al.
Publicado: (2016)

bla (KPC-2) overexpression and bla (GES-5) carriage as major imipenem/relebactam resistance mechanisms in Pseudomonas aeruginosa high-risk clones ST463 and ST235, respectively, in China
por: Li, Yue, et al.
Publicado: (2023)

KPC-3–Producing Serratia marcescens Outbreak between Acute and Long-Term Care Facilities, Florida, USA
por: Jimenez, Adriana, et al.
Publicado: (2020)

Interaction of Avibactam with Class B Metallo-β-Lactamases
por: Abboud, Martine I., et al.
Publicado: (2016)

In Vitro Activity of Delafloxacin and Microbiological Response against Fluoroquinolone-Susceptible and Nonsusceptible Staphylococcus aureus Isolates from Two Phase 3 Studies of Acute Bacterial Skin and Skin Structure Infections
por: McCurdy, S., et al.
Publicado: (2017)

Analyses of a Ceftazidime-Avibactam-Resistant Citrobacter freundii Isolate Carrying bla(KPC-2) Reveals a Heterogenous Population and Reversible Genotype
por: Castanheira, Mariana, et al.
Publicado: (2018)

Phenotypic and Genetic Analysis of KPC-49, a KPC-2 Variant Conferring Resistance to Ceftazidime–Avibactam and Maintaining Resistance to Imipenem and Meropenem
por: Yu, Meng, et al.
Publicado: (2023)

Emergence of KPC-134, a KPC-2 variant associated with ceftazidime-avibactam resistance in a ST11 Klebsiella pneumoniae clinical strain
por: Huang, Xiangning, et al.
Publicado: (2023)

Mutations in porin LamB contribute to ceftazidime-avibactam resistance in KPC-producing Klebsiella pneumoniae
por: Guo, Yingyi, et al.
Publicado: (2021)

1285. Identification of KPC Omega Loop Variant R163S Conferring Ceftazidime-Avibactam Resistance
por: Maris, Alexander S, et al.
Publicado: (2021)

Cost-Effectiveness of Short Course of Ceftazidime/Avibactam for K. pneumoniae-KPC Bloodstream Infections in Italy
por: De Benedetto, Ilaria, et al.
Publicado: (2023)

The Effectiveness of Imipenem–Relebactam against Ceftazidime-Avibactam Resistant Variants of the KPC-2 β-Lactamase
por: Papp-Wallace, Krisztina M., et al.
Publicado: (2023)

2160. Emergence of INDEL Mutations in KPC-2: Insights into Ceftazidime-Avibactam and Imipenem-Relebactam Efficacy
por: Brunetti, Florencia, et al.
Publicado: (2023)

Reduced Ceftazidime-Avibactam Susceptibility in KPC-Producing Klebsiella pneumoniae From Patients Without Ceftazidime-Avibactam Use History – A Multicenter Study in China
por: Cui, Xiaoyan, et al.
Publicado: (2020)

Dynamic evolution of ceftazidime–avibactam resistance due to interchanges between bla(KPC-2) and bla(KPC-145) during treatment of Klebsiella pneumoniae infection
por: Chen, Yili, et al.
Publicado: (2023)

Outbreak of Klebsiella pneumoniae ST11 Resistant To Ceftazidime-Avibactam Producing KPC-31 and the Novel Variant KPC-115 during COVID-19 Pandemic in Argentina
por: Nicola, Federico, et al.
Publicado: (2022)

Successful treatment of KPC-MDR septic shock with ceftazidime-avibactam in a pediatric critically ill patient
por: Vargas, Maria, et al.
Publicado: (2019)

Isolation of a Ceftazidime-Avibactam-Resistant bla(KPC-71)-Positive Klebsiella pneumoniae Clinical Isolate
por: Shen, Siquan, et al.
Publicado: (2022)

Ceftazidime–Avibactam in Combination with Imipenem as Salvage Therapy for ST11 KPC-33-Producing Klebsiella pneumoniae
por: Ding, Li, et al.
Publicado: (2022)

Identification of KPC-112 from an ST15 Klebsiella pneumoniae Strain Conferring Resistance to Ceftazidime-Avibactam
por: Shen, Siquan, et al.
Publicado: (2022)

Resistance to Ceftazidime/Avibactam in Klebsiella pneumoniae KPC-Producing Isolates: A Real-Life Observational Study
por: Campogiani, Laura, et al.
Publicado: (2023)

Ceftazidime-Avibactam Resistance in Klebsiella pneumoniae Sequence Type 11 Due to a Mutation in Plasmid-Borne bla(kpc-2) to bla(kpc-33), in Henan, China
por: Li, Debao, et al.
Publicado: (2021)

Impact of ompk36 genotype and KPC subtype on the in vitro activity of ceftazidime/avibactam, imipenem/relebactam and meropenem/vaborbactam against KPC-producing K. pneumoniae clinical isolates
por: Rogers, Tara M, et al.
Publicado: (2023)

Emergence of KPC-113 and KPC-114 variants in ceftazidime-avibactam-resistant Klebsiella pneumoniae belonging to high-risk clones ST11 and ST16 in South America
por: Vásquez-Ponce, Felipe, et al.
Publicado: (2023)

Clinical and Genomic Epidemiology of Carbapenem-Nonsusceptible Citrobacter spp. at a Tertiary Health Care Center over 2 Decades
por: Babiker, Ahmed, et al.
Publicado: (2020)

Homologous Recombination within Large Chromosomal Regions Facilitates Acquisition of β-Lactam and Vancomycin Resistance in Enterococcus faecium
por: García-Solache, Mónica, et al.
Publicado: (2016)

Diversity among bla(KPC)-containing plasmids in Escherichia coli and other bacterial species isolated from the same patients
por: Hazen, Tracy H., et al.
Publicado: (2018)

Multiple Novel Ceftazidime-Avibactam-Resistant Variants of bla(KPC-2)-Positive Klebsiella pneumoniae in Two Patients
por: Shi, Qingyu, et al.
Publicado: (2022)

Diversity of Ceftazidime-Avibactam Resistance Mechanism in KPC2-Producing Klebsiella pneumoniae Under Antibiotic Selection Pressure
por: Jiang, Min, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_q2gphu9d2io1hteeihj3f65sv1